Xiubao Ren
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View article: Advancing CIK cell immunotherapy: highlights from the second international conference on DC-CIK and CAR-CIK approaches
Advancing CIK cell immunotherapy: highlights from the second international conference on DC-CIK and CAR-CIK approaches Open
View article: ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancer
ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancer Open
Cancer stem cells (CSC) and the immunosuppressive microenvironments are key drivers of breast cancer (BC) progression and drug resistance. However, the molecular mechanisms by which One Cut Homeobox 2 (ONECUT2) governs CSC and the tumor im…
View article: Efficacy of single low-dose dexamethasone with NEPA for the 168 h prevention of highly or moderately emetogenic chemotherapy
Efficacy of single low-dose dexamethasone with NEPA for the 168 h prevention of highly or moderately emetogenic chemotherapy Open
Background Dexamethasone (DEX) can cause various side effects, particularly when used over several consecutive days to prevent chemotherapy-induced nausea and vomiting (CINV). Efforts to minimize the dose and frequency of DEX present chall…
View article: Coupled dynamic simulation of wind turbine structures and tuned liquid dampers based on Adams
Coupled dynamic simulation of wind turbine structures and tuned liquid dampers based on Adams Open
This study establishes a structural-TLD coupled dynamic simulation model based on the coupled vibration theory of elastic structures-fluids and Adams’ virtual prototype technology. The model’s accuracy and applicability were validated by c…
View article: Genetic biomarker study of sunvozertinib for clinical prognosis and prediction in NSCLC with EGFR exon 20 insertion mutation
Genetic biomarker study of sunvozertinib for clinical prognosis and prediction in NSCLC with EGFR exon 20 insertion mutation Open
This is a report of biomarker analysis for sunvozertinib, a leading epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting EGFR exon 20 insertion mutation (exon20ins) non-small cell lung cancer (NSCLC). There is …
View article: CK2B Induces CD8<sup>+</sup> T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer
CK2B Induces CD8<sup>+</sup> T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer Open
Anti‐PD‐1 therapy has left an indelible mark in the field of non‐small‐cell lung cancer (NSCLC) treatment; however, its efficacy is limited in clinical practice owing to differences in the degree of effector T‐cell exhaustion. Casein kinas…
View article: Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase
Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase Open
The dual-reporter system using both fluorescence and chemiluminescence was successfully constructed. Using this method, we identified effective candidate PROTACs against SIRT2. The dual-reporter system may accelerate drug discovery during …
View article: Comparison of the efficacy of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients: meta-analysis of randomized controlled trials
Comparison of the efficacy of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients: meta-analysis of randomized controlled trials Open
Background: Preoperative neoadjuvant chemoradiotherapy (nCRT) is considered to be the standard treatment strategy for locally advanced rectal cancer (LARC); however, the risk of adverse events and postoperative recurrence remains significa…
View article: Efficacy and safety of bevacizumab biosimilar SIBP04 compared with bevacizumab (Avastin®) as first-line treatment for locally advanced or metastatic non-squamous non-small-cell lung cancer: A randomized, double-blind, phase 3 trial
Efficacy and safety of bevacizumab biosimilar SIBP04 compared with bevacizumab (Avastin®) as first-line treatment for locally advanced or metastatic non-squamous non-small-cell lung cancer: A randomized, double-blind, phase 3 trial Open
View article: Elucidating the synergistic roles of CD4&#x002B; T and dendritic cells in antitumor immunity
Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity Open
View article: Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages
Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages Open
Objective: The combination of epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint inhibitors (ICIs) leads to an increased incidence of severe immune-related adverse events (irAEs). However, the me…
View article: Effects of Wnt signaling pathway on tertiary lymphoid structure in the immune microenvironment of colorectal cancer with different MMR subtypes
Effects of Wnt signaling pathway on tertiary lymphoid structure in the immune microenvironment of colorectal cancer with different MMR subtypes Open
Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM), as the important components of tumor microenvironment, play key roles in the anti-tumor immunity and therapy functions in cancer patients. However, the TRM and TLS …
View article: Ferroptosis-related genes in osteoporosis: a bioinformatics analysis and &lt;italic&gt;in vitro&lt;/italic&gt; study
Ferroptosis-related genes in osteoporosis: a bioinformatics analysis and <italic>in vitro</italic> study Open
This study has identified six ferroptosis-related hub genes in osteoporosis, which may be used as novel biomarkers for the early diagnosis and treatment of osteoporosis.
View article: Advances in adoptive cellular immunotherapy and therapeutic breakthroughs in multiple myeloma
Advances in adoptive cellular immunotherapy and therapeutic breakthroughs in multiple myeloma Open
The basic idea of modulating the immune system to better recognize and fight tumor cells has led to the successful introduction of adoptive cellular immunotherapy (ACT). ACT-based treatment regimens, in which the patient's own immune cells…
View article: Association of concomitant H1 antihistamine and immune checkpoint inhibitor therapy on survival outcome and safety in patients with advanced primary lung cancer: a cohort study
Association of concomitant H1 antihistamine and immune checkpoint inhibitor therapy on survival outcome and safety in patients with advanced primary lung cancer: a cohort study Open
Concomitant use of H1 antihistamines can improve immunotherapy efficacy and reduce irAEs. Meanwhile, concomitant use of H2 antihistamines is associated with reduced PFS and OS time.
View article: Novel FABP4+C1q+ macrophages enhance antitumor immunity and associated with response to neoadjuvant pembrolizumab and chemotherapy in NSCLC via AMPK/JAK/STAT axis
Novel FABP4+C1q+ macrophages enhance antitumor immunity and associated with response to neoadjuvant pembrolizumab and chemotherapy in NSCLC via AMPK/JAK/STAT axis Open
View article: Corrigendum: Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer
Corrigendum: Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer Open
[This corrects the article DOI: 10.3389/fimmu.2024.1302903.].
View article: Editorial: Endogenous danger signals in cancer immunology and immunotherapy
Editorial: Endogenous danger signals in cancer immunology and immunotherapy Open
Citation: Ren X, Gao J and Jiang J (2024) Editorial: Endogenous danger signals in cancer immunology and immunotherapy. Front. Immunol. 15:1438972. doi: 10.3389/fimmu.2024.1438972
View article: XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial Open
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial (ClinicalTrials.gov: NCT039501…
View article: A retrospective analysis of mature T- and NK-cell lymphomas
A retrospective analysis of mature T- and NK-cell lymphomas Open
Mature T- and natural killer (NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T- and NK-cell lymphomas is 2.1 per 100,000 people, according to a US report[1][…
View article: 20P Genomic profiles in EGFR mutant locally advanced or metastatic NSCLC patients post osimertinib first line treatment failure: An interim analysis of GPS study
20P Genomic profiles in EGFR mutant locally advanced or metastatic NSCLC patients post osimertinib first line treatment failure: An interim analysis of GPS study Open
Osimertinib represents the current standard treatment for advanced EGFR-mutated NSCLC in the first-line (1L) setting. Acquired resistance inevitably occurs. The exploration of genomic profiles in resistant patients (pts) is vital. EGFR mut…
View article: Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer
Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer Open
Background Immune checkpoint therapy, involving the programmed cell death 1 (PD-1) monoclonal antibody, has revolutionized the treatment of cancer. Tertiary lymphatic structure (TLS) serves as an immune indicator to predict the efficacy of…
View article: Anlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials
Anlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials Open
Murine cytokine-induced killer (CIK) cells are heterologous cells that kill various allogeneic and isogenic tumors and have functional and phenotypic characteristics of natural killer cells and T lymphocytes. However, the effect of CIK cel…
View article: Effects of immunogenic cell death-inducing chemotherapeutics on the immune cell activation and tertiary lymphoid structure formation in melanoma
Effects of immunogenic cell death-inducing chemotherapeutics on the immune cell activation and tertiary lymphoid structure formation in melanoma Open
Background The infiltration and activation of immune cells in the tumor microenvironment (TIME) affect the prognosis of patients with cancer. Tertiary lymphoid structure (TLS) formation favors tumour- infiltrating-lymphocyte (TIL) recruitm…
View article: Neutrophils in the era of single-cell RNA sequencing: functions and targeted therapies in cancer
Neutrophils in the era of single-cell RNA sequencing: functions and targeted therapies in cancer Open
Neutrophils, a crucial component of the innate immune system, are the most abundant bone marrow-derived eukaryotic cell in human blood. The functional importance of neutrophils is often overlooked because neutrophils are short-lived, termi…
View article: Potential value of efficacy prediction and treatment of NK cells in extensive stage small cell lung cancer
Potential value of efficacy prediction and treatment of NK cells in extensive stage small cell lung cancer Open
Although the emergence of immunotherapy has broken the deadlock of extensive stage small cell lung cancer (ES-SCLC), the study of markers for predicting efficacy is the key to the breakthrough of immunotherapy, and exploring more innovativ…
View article: Cytokine-induced killer (CIK) cells, successes and challenges: report on the first international conference dedicated to the clinical translation of this unique adoptive cell immunotherapy
Cytokine-induced killer (CIK) cells, successes and challenges: report on the first international conference dedicated to the clinical translation of this unique adoptive cell immunotherapy Open
View article: STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity
STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity Open
Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP (cGAMP) in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations including…
View article: Osimertinib Increase Immune Checkpoint Inhibitors-Related Severe Adverse Events Via Activating the Il-6/Jak/Stat3 Pathway of Egfr-Positive Macrophages
Osimertinib Increase Immune Checkpoint Inhibitors-Related Severe Adverse Events Via Activating the Il-6/Jak/Stat3 Pathway of Egfr-Positive Macrophages Open
View article: Correction: In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma
Correction: In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma Open