Xiao-kun Zhang
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View article: Affective and Psycholinguistic Norms for 1200 Two‐character Chinese Words
Affective and Psycholinguistic Norms for 1200 Two‐character Chinese Words Open
The interplay between emotion and language has drawn increasing attention from researchers in various fields, such as psycholinguistics, neurolinguistics, and artificial intelligence. The classification of emotional words is crucial to exp…
View article: Time course of indirect reply comprehension in the young and older adults: an event-related potential study
Time course of indirect reply comprehension in the young and older adults: an event-related potential study Open
Introduction In verbal communication, speakers often use implicit utterances that need listeners to interpret via pragmatic inference. As individuals age, their ability to make efficient and accurate pragmatic inferences may decline, leadi…
View article: RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis
RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis Open
Hepatic stellate cells (HSCs) are the primary fibrogenic cells in the liver, and their activation plays a crucial role in the development and progression of hepatic fibrosis. Here, we report that retinoid X receptor-alpha (RXRα), a …
View article: An Experimental Study of the Characteristics of Oxidation Displacement via Air Injection in a Deep, Medium–High-Pressure Reservoir
An Experimental Study of the Characteristics of Oxidation Displacement via Air Injection in a Deep, Medium–High-Pressure Reservoir Open
A high-temperature and high-pressure experimental device was upgraded to accommodate a maximum pressure of 40 MPa and a maximum temperature of 800 °C. Using this experimental device, one-dimensional oxidation displacement experiments were …
View article: Commonality and Individuality! Integrating Humor Commonality with Speaker Individuality for Humor Recognition
Commonality and Individuality! Integrating Humor Commonality with Speaker Individuality for Humor Recognition Open
Humor recognition aims to identify whether a specific speaker's text is humorous. Current methods for humor recognition mainly suffer from two limitations: (1) they solely focus on one aspect of humor commonalities, ignoring the multifacet…
View article: Commonality and Individuality! Integrating Humor Commonality with Speaker Individuality for Humor Recognition
Commonality and Individuality! Integrating Humor Commonality with Speaker Individuality for Humor Recognition Open
View article: Experimental and Numerical Simulation Studies on Sweep Efficiency in Electrical Heating-Co2 Assisted Sagd for Heavy Oil Reservoirs with Interbeds
Experimental and Numerical Simulation Studies on Sweep Efficiency in Electrical Heating-Co2 Assisted Sagd for Heavy Oil Reservoirs with Interbeds Open
View article: Inhibition processing in code-switching among Chinese–English–Japanese trilinguals: Evidence from the <i>n</i>–2 language repetition costs
Inhibition processing in code-switching among Chinese–English–Japanese trilinguals: Evidence from the <i>n</i>–2 language repetition costs Open
Aims and Objectives: The current study aimed to investigate whether there was inhibitory processing in code-switching during language comprehension among Chinese–English–Japanese trilinguals and whether n–2 language repetition costs were c…
View article: Unveiling the Mechanisms of Apoptosis Induction by Deep‐Sea‐Derived Polyketide‐Terpenoid Hybrids from <i>Penicillium allii‐sativi</i>: A Focus on Mitochondrial and <scp>mTOR</scp> Pathways
Unveiling the Mechanisms of Apoptosis Induction by Deep‐Sea‐Derived Polyketide‐Terpenoid Hybrids from <i>Penicillium allii‐sativi</i>: A Focus on Mitochondrial and <span>mTOR</span> Pathways Open
Comprehensive Summary A chemical investigation of the deep‐sea‐derived fungus Penicillium allii‐sativi MCCC 3A00580 resulted in the discovery of four new meroterpenoids ( 1 — 4 ) and one related known co‐metabolite ( 5 ). These meroterpeno…
View article: Enhancing Textual Personality Detection toward Social Media: Integrating Long-term and Short-term Perspectives
Enhancing Textual Personality Detection toward Social Media: Integrating Long-term and Short-term Perspectives Open
Textual personality detection aims to identify personality characteristics by analyzing user-generated content on social media platforms. Extensive psychological literature highlights that personality encompasses both long-term stable trai…
View article: Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates
Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates Open
View article: Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation
Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation Open
Background The maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate regulations of the individual miRNA maturation are largely unknown. Retinoid x receptor alpha …
View article: Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic molecule. N…
View article: Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
The Supplementary Methods show the Synthesis of DIM-C-pPhCF3+MeSO3- (BI1071); Figure S1 shows BI1071 induces apoptosis in different cancer cell lines; Fig. S2 shows BI1071 induces apoptosis in different breast cancer cell lines; Fig. S3 sh…
View article: Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Data from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic molecule. N…
View article: Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
Supplementary methods and Supplementary Figures S1-S8 from BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway Open
The Supplementary Methods show the Synthesis of DIM-C-pPhCF3+MeSO3- (BI1071); Figure S1 shows BI1071 induces apoptosis in different cancer cell lines; Fig. S2 shows BI1071 induces apoptosis in different breast cancer cell lines; Fig. S3 sh…
View article: Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Retinoid X receptor alpha (RXRα) and its N-terminally truncated version, tRXRα, are widely implicated in cancer development and represent intriguing targets for cancer prevention and treatment. Successful manipulation of RXRα and tRXRα req…
View article: Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Data from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Retinoid X receptor alpha (RXRα) and its N-terminally truncated version, tRXRα, are widely implicated in cancer development and represent intriguing targets for cancer prevention and treatment. Successful manipulation of RXRα and tRXRα req…
View article: Supplementary Figure Legend from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Figure Legend from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Figure Legend. Legends for Supplementary Figures S1-S6.
View article: Supplementary Methods from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Supplementary Methods from Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB Open
Supplementary Methods. Description of additional methods and procedures used in the study.
View article: Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma
Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma Open
Prostate adenocarcinoma (PRAD) is the most frequent malignancy, and is the second leading cause of death due to cancer in men. Thus, new prognostic biomarkers and drug targets for PRAD are urgently needed. As we know, nuclear receptor Nur7…
View article: Dexmedetomidine adjunct to ropivacaine for ultrasound-guided transversus abdominis plane block for open inguinal hernia repair in the older adults: A randomised clinical trial
Dexmedetomidine adjunct to ropivacaine for ultrasound-guided transversus abdominis plane block for open inguinal hernia repair in the older adults: A randomised clinical trial Open
Objective: The aim of this study was to evaluate the effect of adding dexmedetomidine to ropivacaine on pain relief and quality of recovery in older patients undergoing open inguinal hernia repair surgeries. Methods: This was a prospective…
View article: Additional file 2 of Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation
Additional file 2 of Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation Open
Additional file 2. The individual data values for Fig. 1a-d; Fig. 2b-d; Fig. 3b-d; Fig. 4a-e; Fig. 5a-d; Fig. 6a, c, and e; Fig. 7a and b.
View article: Chemical Constituents of the Deep-Sea-Derived Penicillium citreonigrum MCCC 3A00169 and Their Antiproliferative Effects
Chemical Constituents of the Deep-Sea-Derived Penicillium citreonigrum MCCC 3A00169 and Their Antiproliferative Effects Open
Six new citreoviridins (citreoviridins J–O, 1–6) and twenty-two known compounds (7–28) were isolated from the deep-sea-derived Penicillium citreonigrum MCCC 3A00169. The structures of the new compounds were determined by spectroscopic meth…
View article: Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish
Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish Open
The glucagon receptor (GCGR) is a potential target for diabetes therapy. Several emerging GCGR antagonism-based therapies are under preclinical and clinical development. However, GCGR antagonism, as well as genetically engineered GCGR defi…
View article: Evidence for dynamic attentional bias toward positive emotion-laden words: A behavioral and electrophysiological study
Evidence for dynamic attentional bias toward positive emotion-laden words: A behavioral and electrophysiological study Open
There has been no consensus on the neural dissociation between emotion-label and emotion-laden words, which remains one of the major concerns in affective neurolinguistics. The current study adopted dot-probe tasks to investigate the valen…
View article: The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease
The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease Open
View article: The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain Open
Prolongation of postsurgical pain caused by pre-operative stress is a clinically significant problem, although the mechanisms are not fully understood. Stress can promote the pro-inflammatory activation of microglia, and the transcription …
View article: Design, Synthesis and Biological Evaluation of Acylhydrazones-Based Derivatives as RXRα-Targeted Anti-Mitotic Agents
Design, Synthesis and Biological Evaluation of Acylhydrazones-Based Derivatives as RXRα-Targeted Anti-Mitotic Agents Open
View article: Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2
Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2 Open