Kunyu Yang
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View article: A phase I study of the OX40 agonist BGB-A445 with or without tislelizumab, an anti–PD-1 monoclonal antibody, in patients with advanced solid tumors: dose-escalation results
A phase I study of the OX40 agonist BGB-A445 with or without tislelizumab, an anti–PD-1 monoclonal antibody, in patients with advanced solid tumors: dose-escalation results Open
BGB-A445 was well tolerated and demonstrated on-target immune activation at clinically relevant doses. Antitumor activity was observed across cohorts.
View article: Violin Major Music Alleviates University Students’ Anxiety Maybe through the dACC and DLPFC Circuits
Violin Major Music Alleviates University Students’ Anxiety Maybe through the dACC and DLPFC Circuits Open
University students may encounter high levels of anxiety or depression, which can adversely impact their daily lives and academic performance and even lead to illness. Recently, studies have reported that music therapy can effectively alle…
View article: LadybirdBase: a comprehensive biology, ecology and omics resource for ladybird beetles (Coccinellidae)
LadybirdBase: a comprehensive biology, ecology and omics resource for ladybird beetles (Coccinellidae) Open
Ladybird beetles (Coleoptera: Coccinellidae) represent a highly diverse insect group comprising over 6000 species. Recently, an increasing amount of omics data on ladybirds has accumulated. To better understand their roles and adaptations …
View article: Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response
Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response Open
Radioresistance is one of the important reasons for local recurrence and distant metastasis in non-small cell lung cancer (NSCLC). Itaconate primarily functions as an anti-inflammatory metabolite in macrophages, however, its role in radiot…
View article: Neutrophil extracellular traps in cancer: From mechanisms to treatments
Neutrophil extracellular traps in cancer: From mechanisms to treatments Open
Neutrophil extracellular traps (NETs) are reticular ultrastructures released by activated neutrophils. As the reaction products of neutrophils, NETs have been identified as crucial effectors in pathogen defence and autoimmune diseases. Rec…
View article: Boosting mRNA cancer vaccine efficacy via targeting <i>Irg1</i> on macrophages in lymph nodes
Boosting mRNA cancer vaccine efficacy via targeting <i>Irg1</i> on macrophages in lymph nodes Open
Rationale: mRNA cancer vaccines show great promise for tumor therapy, but the therapeutic efficacy is limited. Metabolites play critical roles in immunomodulation. However, their role in mRNA cancer vaccines remains poorly understood. Meth…
View article: Figure S1-S10 from Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy
Figure S1-S10 from Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy Open
Figure S1 shows the metabolic alterations induced by anti-PD-1 treatment in mice. Figure S2 presents the effects of itaconate on anti-PD-1 therapy in vivo. Figure S3 shows the impact of Acod1 deletion on the tumor immune microenvironment. …
View article: Table S1-S5 from Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy
Table S1-S5 from Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy Open
Table S1 presents the sequences of primers used for RT-qPCR analysis. Table S2 lists the sequences of primers used for ChIP-PCR. Table S3 contains the differentially expressed metabolites identified in tumor tissues of Lewis tumor-bearing …
View article: Data from Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy
Data from Macrophage-Derived Itaconate Suppresses Dendritic Cell Function to Promote Acquired Resistance to Anti–PD-1 Immunotherapy Open
Adaptive resistance to immunotherapy remains a significant challenge in cancer treatment. The reshaping of the tumor immune microenvironment in response to therapeutic pressures is a crucial factor contributing to this resistance. In this …
View article: Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma
Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma Open
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demon…
View article: A B7H3-targeting antibody–drug conjugate in advanced solid tumors: a phase 1/1b trial
A B7H3-targeting antibody–drug conjugate in advanced solid tumors: a phase 1/1b trial Open
Antibody-drug conjugates (ADCs) have emerged as a transformative modality in the treatment of solid tumors. YL201, a novel B7H3-targeting ADC, leverages a tumor microenvironment activable linker-payload platform, coupled with a novel topoi…
View article: The role of high-tech certification in enterprise green innovation: from the perspectives of substantive innovation and strategic innovation
The role of high-tech certification in enterprise green innovation: from the perspectives of substantive innovation and strategic innovation Open
Sustainable development comes from a balance between economic growth and environmental protection, with due consideration of long-term impacts on environment. Leveraging policy tools to promote green innovation is a critical strategy for a…
View article: Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma
Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma Open
Advanced extranodal extension (ENE) in cervical lymph nodes (CLNs) increases the risk of distant metastasis in nasopharyngeal carcinoma (NPC). The 9th NPC staging system classifies N1/N2 patients with advanced CLN ENE as N3 due to similar …
View article: A risk prediction model for acute kidney injury following acute heart failure in an emergency department cohort in China
A risk prediction model for acute kidney injury following acute heart failure in an emergency department cohort in China Open
This risk prediction model might assist physician to predict AKI following AHF effectively in the emergency setting.
View article: Correction: Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery
Correction: Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery Open
Correction for ‘Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery’ by Qianyuan He et al. , Nanoscale , 2020, 12 , 14788–14800, https://doi.org/10.1039/D0NR02750B.
View article: SMARCB1/INI-1-Deficient sinonasal carcinoma demonstrates a poor prognosis but favorable clinical outcomes after PD-1/PD-L1 inhibitor therapy: A case series
SMARCB1/INI-1-Deficient sinonasal carcinoma demonstrates a poor prognosis but favorable clinical outcomes after PD-1/PD-L1 inhibitor therapy: A case series Open
Despite advances in multimodal cancer therapy, such as combining radical surgery with high-intensity chemoradiotherapy, for SMARCB1/INI-1-deficient sinonasal carcinoma (SDSC), the prognosis of patients remains poor. Immunotherapy is gainin…
View article: Effect of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer: a prospective observation study
Effect of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer: a prospective observation study Open
Background Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes in the third-line and subsequent treatments of patients with microsatellite stable metastatic colorectal cancer (MSS-mCRC…
View article: The Impact of High-Tech Enterprise Certification on Green Innovation: Evidence from Listed Companies in China
The Impact of High-Tech Enterprise Certification on Green Innovation: Evidence from Listed Companies in China Open
Against the backdrop of global efforts towards carbon peak and carbon neutrality, enhancing the level of green innovation in enterprises represents a significant challenge faced by governments worldwide. The practice of establishing a cert…
View article: Gut bacteria facilitate pollinivory of the ladybird beetle Micraspis discolor
Gut bacteria facilitate pollinivory of the ladybird beetle Micraspis discolor Open
The ladybird beetle Micraspis discolor plays an important role as a predator of various arthropods within Asia’s rice ecosystems. While pollen could serve as an alternative diet for this beetle, facilitating mass-rearing, its pollinivory m…
View article: Anatomical and dosimetric variations during volumetric modulated arc therapy in patients with locally advanced nasopharyngeal carcinoma after induction therapy: Implications for adaptive radiation therapy
Anatomical and dosimetric variations during volumetric modulated arc therapy in patients with locally advanced nasopharyngeal carcinoma after induction therapy: Implications for adaptive radiation therapy Open
Replanning for post-IT LA-NPC patients appears reasonable at 25F during VMAT. Patients with an initial BMI ≥ 23.5 kg/m2 and not-achieving OR after IT should be considered for adaptive radiation therapy to stabilize the delivered dose.
View article: Evaluation of an automated clinical decision system with deep learning dose prediction and NTCP model for prostate cancer proton therapy
Evaluation of an automated clinical decision system with deep learning dose prediction and NTCP model for prostate cancer proton therapy Open
Objective. To evaluate the feasibility of using a deep learning dose prediction approach to identify patients who could benefit most from proton therapy based on the normal tissue complication probability (NTCP) model. Approach. Two 3D UNe…
View article: Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway
Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway Open
Radiotherapy (RT) is used for over 50 % of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces the release of irradiated tumour c…
View article: Microglia and macrophage metabolism: a regulator of cerebral gliomas
Microglia and macrophage metabolism: a regulator of cerebral gliomas Open
Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intr…
View article: Metabolism, digestion, and horizontal transfer: potential roles and interaction of symbiotic bacteria in the ladybird beetle <i>Novius pumilus</i> and their prey <i>Icerya aegyptiaca</i>
Metabolism, digestion, and horizontal transfer: potential roles and interaction of symbiotic bacteria in the ladybird beetle <i>Novius pumilus</i> and their prey <i>Icerya aegyptiaca</i> Open
In this study, we first time sequenced and analyzed the 16S rRNA gene data of predator ladybird beetles Novius pumilus and globally distributed invasive pest Icerya aegyptiaca at different stages, and combined data with bacterial genome se…
View article: A self‐assembled, genetically engineered, irradiated tumor cell debris vaccine
A self‐assembled, genetically engineered, irradiated tumor cell debris vaccine Open
Vaccine‐based therapeutics for cancers face several challenges including lack of immunogenicity and tumor escape pathways for single antigen targets. It has been reported that radiotherapy has an in situ vaccine effect that provides tumor …