Hereditary multiple exostoses (HME) is an autosomal dominant bone disorder characterized by abnormal bone development. HME mostly involves the forearm, resulting in forearm deformities, limited functional activities, etc . Currently, there are multiple surgical methods including tumor resection with or without ulnar osteotomy and lengthening, simple radial head resection and distal radial hemiepiphysiodesis, but the optimal treatment remains controversial. Ulnar lengthening serves as an effective surgical interven…

Background and Aim: As a classical formula to invigorate blood circulation, Huoxue Tongluo Qiwei Decoction (HTQD) can effectively treat hypertensive erectile dysfunction (ED), but its exact mechanism of action is not yet clear. The goal of this research was to explore the potential mechanism of HTQD in improving hypertensive erectile dysfunction in rats through transcriptomics, network pharmacology, and associated animal experimentations. Methods: The HTQD chemical constituents were screened using high-performance…

The continued rise in recurrence and mortality rates of cervical cancer suggests the need to find novel therapeutic targets. Previous studies suggest that TRIP4 acts as a transcription factor to regulate cervical carcinogenesis and progression. Our aim was to explore whether the key downstream genes of TRIP4 functions same as TRIP4 in promoting cervical cancer development. We analyzed and confirmed the downstream targets of TRIP4 by RNA sequencing in cervical cancer cells with TRIP4 knockdown. The expression corre…

ABSTRACT Objective In vivo transcription factor (TF) ‐mediated gene therapy through astrocyte‐to‐neuron (AtN) conversion has shown therapeutic effects on rodent and non‐human primate cortical ischemic injury in the subacute phase. However, in the clinic, subcortical regions including striatum as well as white matter are vulnerable regions of stroke, with millions of patients beyond subacute phase. In this study, we investigate whether TF‐mediated AtN conversion therapy can be extended to treat chronic‐phase ischem…

Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is among the most prevalent chronic liver diseases worldwide. The expression of YTH domain‐containing protein 1 (YTHDC1) is significantly reduced in patients and mouse models with MASLD. Hepatocyte‐specific knockout of YTHDC1 exacerbates HFD‐induced hepatic lipid accumulation. Lactate accumulation and enhanced arginyl‐tRNA synthetase 1 (AARS1)‐mediated K565‐specific lactylation are shown to drive the ubiquitination‐mediated degradation of YT…