Kun‐Han Lin
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View article: Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity
Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity Open
Heterogeneity in synaptic strength and short‐term plasticity (STP) was characterized in post‐hearing rat calyx of Held synapses at near‐physiological external [Ca 2+ ] under control conditions and after experimentally induced synaptic pote…
View article: Towards Clinical Application: Calcium Waves for In Vitro Qualitative Assessment of Propagated Primary Human Corneal Endothelial Cells
Towards Clinical Application: Calcium Waves for In Vitro Qualitative Assessment of Propagated Primary Human Corneal Endothelial Cells Open
Corneal endothelium cells (CECs) regulate corneal hydration between the leaky barrier of the corneal endothelium and the ionic pumps on the surface of CECs. As CECs do not regenerate, loss of CECs leads to poor vision and corneal blindness…
View article: Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion
Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion Open
The presynaptic SNARE-complex regulator complexin (Cplx) enhances the fusogenicity of primed synaptic vesicles (SVs). Consequently, Cplx deletion impairs action potential-evoked transmitter release. Conversely, though, Cplx loss enhances s…
View article: Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion
Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion Open
Mitochondrial dysfunction induced by acute cardiac ischemia–reperfusion (IR), may increase susceptibility to arrhythmias by perturbing energetics, oxidative stress production and calcium homeostasis. Although changes in mitochondrial morph…
View article: A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity Open
Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional state modeling, we demonstrate that a kinetic scheme con…
View article: A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity Open
Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using non-negative tensor factorization (NTF) and conventional state modelling, we demonstrate that a kinetic sc…
View article: Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice
Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice Open
Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential. We combined capacitance measuremen…
View article: Author response: Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice
Author response: Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Neurotransmitter is released at synapses by fus…