Kunka Mohanram Ramkumar
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View article: Evaluating the Cytokine-Modulating Anti-inflammatory Effects of Ayurvedic Treatments on Non-Communicable Diseases: A Prospective Observational Study
Evaluating the Cytokine-Modulating Anti-inflammatory Effects of Ayurvedic Treatments on Non-Communicable Diseases: A Prospective Observational Study Open
Objectives Chronic inflammation drives non-communicable diseases (NCDs) like diabetes, GERD, hypertension, and osteoarthritis. Ayurveda, an ancient system of medicine, emphasizes personalized treatments to restore balance and modulate immu…
View article: Intelligent Decision Support System Facilitating Early Detection of Cardiovascular Disease
Intelligent Decision Support System Facilitating Early Detection of Cardiovascular Disease Open
Background Cardiovascular disease (CVD) remains the primary cause of mortality worldwide, with higher fatality rates in India. Multi-modal diagnostics integrating electrocardiogram (ECG) analysis, cardiac biomarkers, and region-specific in…
View article: Throughput and load balancing optimization in heterogeneous networks using Red-Tailed Hawk Algorithm
Throughput and load balancing optimization in heterogeneous networks using Red-Tailed Hawk Algorithm Open
In wireless communication networks, the growing need for data has presented significant issues in the last years. This will continue, with mobile consumers' needs for Quality of Service (QoS) changing and their data use skyrocketing. The c…
View article: Antidiabetic Activity of Ayurvedic Niruryadi Gulika in Experimental Diabetes
Antidiabetic Activity of Ayurvedic Niruryadi Gulika in Experimental Diabetes Open
Diabetes mellitus is a chronic metabolic disorder associated with high rates of morbidity and mortality globally. Ayurvedic medicine offers promising approaches for managing diabetes, with Niruryadi Gulika (NG) emerging as a potential ther…
View article: Effect of methoxychlor on liver function, lipid peroxidation, and antioxidants in experimental rats
Effect of methoxychlor on liver function, lipid peroxidation, and antioxidants in experimental rats Open
These findings suggest that methoxychlor exposure disrupts liver function and induces oxidative stress by enhancing lipid peroxidation, thereby depleting natural antioxidant defenses. This study highlights the potential hepatotoxic effects…
View article: Exploring the Role of Hypoxia and HIF-1α in the Intersection of Type 2 Diabetes Mellitus and Endometrial Cancer
Exploring the Role of Hypoxia and HIF-1α in the Intersection of Type 2 Diabetes Mellitus and Endometrial Cancer Open
Diabetes and Cancer are the most complex chronic diseases, accounting for significant global mortality and morbidity. The association between Type 2 DM (T2DM) and endometrial cancer (EC) is multifaced, sharing numerous risk factors, includ…
View article: A Study on Stone Sculpture Chisels in Tamil Nadu
A Study on Stone Sculpture Chisels in Tamil Nadu Open
View article: A Co-Culture System for Studying Cellular Interactions in Vascular Disease
A Co-Culture System for Studying Cellular Interactions in Vascular Disease Open
Cardiovascular diseases (CVDs) are leading causes of morbidity and mortality globally, characterized by complications such as heart failure, atherosclerosis, and coronary artery disease. The vascular endothelium, forming the inner lining o…
View article: Mangiferin Represses Inflammation in Macrophages Under a Hyperglycemic Environment Through Nrf2 Signaling
Mangiferin Represses Inflammation in Macrophages Under a Hyperglycemic Environment Through Nrf2 Signaling Open
Inflammation in macrophages is exacerbated under hyperglycemic conditions, contributing to chronic inflammation and impaired wound healing in diabetes. This study investigates the potential of mangiferin, a natural polyphenol, to alleviate…
View article: Pterostilbene Reverses Epigenetic Silencing of Nrf2 and Enhances Antioxidant Response in Endothelial Cells in Hyperglycemic Microenvironment
Pterostilbene Reverses Epigenetic Silencing of Nrf2 and Enhances Antioxidant Response in Endothelial Cells in Hyperglycemic Microenvironment Open
The epigenetic regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a pivotal redox transcription factor, plays a crucial role in maintaining cellular homeostasis. Recent research has underscored the significance of epigenetic…
View article: LncRNA NEAT1/miR-146a-5p Axis Restores Normal Angiogenesis in Diabetic Foot Ulcers by Targeting mafG
LncRNA NEAT1/miR-146a-5p Axis Restores Normal Angiogenesis in Diabetic Foot Ulcers by Targeting mafG Open
Non-healing lesions in diabetic foot ulcers are a significant effect of poor angiogenesis. Epigenetic regulators, mainly lncRNA and miRNA, are recognized for their important roles in disease progression. We deciphered the regulation of lnc…
View article: Multi-Modal Detection of Cardiovascular Disease at the Community Level
Multi-Modal Detection of Cardiovascular Disease at the Community Level Open
View article: Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease
Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease Open
The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in regulating cellular homeostasis and apoptosis. The NRF2 gene has been implicated in various biological activities, including antioxidant, anti-infl…
View article: Quantitative proteomic analyses uncover regulatory roles of Nrf2 in human endothelial cells
Quantitative proteomic analyses uncover regulatory roles of Nrf2 in human endothelial cells Open
View article: MicroRNA-27b Impairs Nrf2-Mediated Angiogenesis in the Progression of Diabetic Foot Ulcer
MicroRNA-27b Impairs Nrf2-Mediated Angiogenesis in the Progression of Diabetic Foot Ulcer Open
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a stress-activated transcription factor regulating antioxidant genes, and a deficiency thereof, slowing lymphangiogenesis, has been reported in diabetic foot ulcer (DFU). The mode of Nr…
View article: Editorial: Clinical and genetic determinants of diabetes and complications
Editorial: Clinical and genetic determinants of diabetes and complications Open
Diabetes Mellitus (DM) continues to be a significant cause of death worldwide, imposing a substantial burden on global public health. According to the data from International Diabetes Federation, the number of DM patients is expected to in…
View article: New Frontiers in Three-Dimensional Culture Platforms to Improve Diabetes Research
New Frontiers in Three-Dimensional Culture Platforms to Improve Diabetes Research Open
Diabetes mellitus is associated with defects in islet β-cell functioning and consequent hyperglycemia resulting in multi-organ damage. Physiologically relevant models that mimic human diabetic progression are urgently needed to identify ne…
View article: New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects Open
Pterostilbene (PTS), a compound most abundantly found in blueberries, is a natural analog of resveratrol. Several plant species, such as peanuts and grapes, produce PTS. While resveratrol has been extensively studied for its antioxidant pr…
View article: Exosomes as Theranostic Targets: Implications for the Clinical Prognosis of Aggressive Cancers
Exosomes as Theranostic Targets: Implications for the Clinical Prognosis of Aggressive Cancers Open
Exosomes are extracellular vesicles produced by various cell types and extensively distributed in physiological fluids. Because of their significant role in cancer progression, they have been a focal point for the novel cancer therapy appr…
View article: IDF21-0448 Role of miR27b on the regulation of angiogenesis in diabetic foot ulcer through Nrf2 signaling
IDF21-0448 Role of miR27b on the regulation of angiogenesis in diabetic foot ulcer through Nrf2 signaling Open
View article: Green Synthesis of Copper Nanoparticles Using <i>Withania somnifera</i> and Its Antioxidant and Antibacterial Activity
Green Synthesis of Copper Nanoparticles Using <i>Withania somnifera</i> and Its Antioxidant and Antibacterial Activity Open
This study employed green chemistry to synthesize copper nanoparticles (CuNPs) using fresh root extract of Withania somnifera . The size, shape, morphology, and stability of resultant CuNPs were investigated by UV‐Vis spectroscopy, FTIR, t…
View article: Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms
Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms Open
Long non-coding RNAs (lncRNAs) are the novel class of transcripts involved in transcriptional, post-transcriptional, translational, and post-translational regulation of physiology and the pathology of diseases. Studies have evidenced that …
View article: Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications Open
View article: Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice
Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice Open
Objective: To assess the nuclear factor-erythroid 2-related factor-2 (Nrf2) modulatory effect of caffeic acid and protocatechuic acid and determine the anti-tumor activity of these phenolic compounds against Ehrlich ascites carcinoma growt…
View article: Genetic variability, Heritability and Genetic advance studies in Yardlong bean (Vigna unguiculata spp. sesquipedalis) genotypes
Genetic variability, Heritability and Genetic advance studies in Yardlong bean (Vigna unguiculata spp. sesquipedalis) genotypes Open
A field experiment was carried out at farmer field in Pudukurapettai village, Virudhachalam, Tamilnadu during 2019 to study genetic variability, heritability and genetic advance expressed as per cent of mean for yield and yield attributing…
View article: Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells
Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells Open
Endoplasmic reticulum (ER) plays a key role in the folding, modification, and trafficking of proteins. When the homeostasis of the ER is disturbed, un/misfolded proteins accumulate in the ER which leads to ER stress. Sustained ER stress re…
View article: [Retracted] Association between Tumor Prognosis Marker Visfatin and Proinflammatory Cytokines in Hypertensive Patients
[Retracted] Association between Tumor Prognosis Marker Visfatin and Proinflammatory Cytokines in Hypertensive Patients Open
Visfatin has been reported as a risk factor and a potential diagnostic marker in cancer. It is an adipokine, secreted by visceral fat and associated with the pathogenesis of arterial hypertension. We investigated the circulatory levels of …
View article: Crosstalk between endoplasmic reticulum stress and oxidative stress in the progression of diabetic nephropathy
Crosstalk between endoplasmic reticulum stress and oxidative stress in the progression of diabetic nephropathy Open
View article: Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers
Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers Open
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a protein of the leucine zipper family, which mitigates inflammation and employs cytoprotective effects. Attempting to unravel the epigenetic regulation of type 2 diabetes mellitus (T2D…
View article: Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers
Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers Open
The genetic polymorphism in the nuclear factor erythroid 2-related factor 2 (Nrf2) gene has been reported as one of the prognosis markers for various diseases, including cancer. Nrf2 is a key transcription factor involved in wound healing …