Kun Zou
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View article: Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3 Open
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is among the most prevalent chronic liver diseases worldwide. The expression of YTH domain‐containing protein 1 (YTHDC1) is significantly reduced in patients and mouse models…
View article: Lateral external fixation plus K-wire for pediatric supracondylar humeral fracture with medial comminution: a retrospective study of 53 cases in a tertiary medical center
Lateral external fixation plus K-wire for pediatric supracondylar humeral fracture with medial comminution: a retrospective study of 53 cases in a tertiary medical center Open
For pediatric SCHF with medial comminution, external fixator (EF) plus KW is a feasible alternative without the risk of iatrogenic ulnar nerve injury.
View article: Ulnar lengthening in the treatment of forearm deformity caused by hereditary multiple exostoses in children
Ulnar lengthening in the treatment of forearm deformity caused by hereditary multiple exostoses in children Open
Hereditary multiple exostoses (HME) is an autosomal dominant bone disorder characterized by abnormal bone development. HME mostly involves the forearm, resulting in forearm deformities, limited functional activities, etc . Currently, there…
View article: Transcription Factor‐Based Gene Therapy Enables Functional Repair of Rat Following Chronic Ischemic Stroke
Transcription Factor‐Based Gene Therapy Enables Functional Repair of Rat Following Chronic Ischemic Stroke Open
Objective In vivo transcription factor (TF) ‐mediated gene therapy through astrocyte‐to‐neuron (AtN) conversion has shown therapeutic effects on rodent and non‐human primate cortical ischemic injury in the subacute phase. However, in the c…
View article: GATA2 promotes cervical cancer progression under the transcriptional activation of TRIP4
GATA2 promotes cervical cancer progression under the transcriptional activation of TRIP4 Open
The continued rise in recurrence and mortality rates of cervical cancer suggests the need to find novel therapeutic targets. Previous studies suggest that TRIP4 acts as a transcription factor to regulate cervical carcinogenesis and progres…
View article: Integrated Network Pharmacology and Transcriptomics Analysis to Elucidate the Mechanism of Huoxue Tongluo Qiwei Decoction in the Treatment of Erectile Dysfunction in Spontaneously Hypertensive Rats through Angii-Activated Pkcε Pathway
Integrated Network Pharmacology and Transcriptomics Analysis to Elucidate the Mechanism of Huoxue Tongluo Qiwei Decoction in the Treatment of Erectile Dysfunction in Spontaneously Hypertensive Rats through Angii-Activated Pkcε Pathway Open
Background and Aim: As a classical formula to invigorate blood circulation, Huoxue Tongluo Qiwei Decoction (HTQD) can effectively treat hypertensive erectile dysfunction (ED), but its exact mechanism of action is not yet clear. The goal of…
View article: Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers
Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers Open
A robust method is reported to introduce site-specific sulfonium warheads to peptides and proteins by cysteine alkylation. This method enables the preparation of nucleosome probes that crosslink to H3K36 methylation readers LEDGF and NSD2.
View article: Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity
Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity Open
Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers-arginine demethylases-remain mysterious. Here we ide…
View article: Bioinformatics Combined With Experimental Modeling to Study the Molecular Mechanism of Xuefu Zhuyu Decoction to Improve Erectile Dysfunction Associated With Asthma in Rats
Bioinformatics Combined With Experimental Modeling to Study the Molecular Mechanism of Xuefu Zhuyu Decoction to Improve Erectile Dysfunction Associated With Asthma in Rats Open
Asthma is associated with chronic systemic inflammation, and inflammatory factors can damage vascular endothelial cells, thus impairing erectile function (ED). Xuefu Zhuyu decoction (XFZYD) can inhibit inflammation and promote angiogenesis…
View article: The inappropriate application of imidacloprid destroys the ability of predatory natural enemies to control pests in the food chain: A case study of the feeding behavior of Orius similis on Frankliniella occidentalis
The inappropriate application of imidacloprid destroys the ability of predatory natural enemies to control pests in the food chain: A case study of the feeding behavior of Orius similis on Frankliniella occidentalis Open
Insecticides are an indispensable and important tool for agricultural production. However, the inappropriate application of insecticides can cause damage to the food chain and ecosystem. Orius similis is an important predatory and natural …
View article: Caryophyllene-type sesquiterpenes from the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach
Caryophyllene-type sesquiterpenes from the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach Open
Two new caryophyllene-type sesquiterpenes pestalotiopsins U and V ( 1 and 2 ) and three known compounds pestalotiopsin B ( 7 ), pestaloporinate B ( 8 ), and pestalotiopsin C ( 9 ) were isolated by the cultivation of the endophytic fungus P…
View article: Sweet triterpenoid glycoside from Cyclocarya paliurus ameliorates obesity-induced insulin resistance through inhibiting the TLR4/NF-κB/NLRP3 inflammatory pathway
Sweet triterpenoid glycoside from Cyclocarya paliurus ameliorates obesity-induced insulin resistance through inhibiting the TLR4/NF-κB/NLRP3 inflammatory pathway Open
Our prophase studies have manifested that the sweet triterpenoid glycoside from the leaves of Cyclocarya paliurus (CPST) effectively improved the disorders of glucolipid metabolism in vitro and in patients. The current purpose was to furth…
View article: A novel polyionic liquid with lubricity and viscosity-increasing dual functionalities as the additive in aqueous lubrication system
A novel polyionic liquid with lubricity and viscosity-increasing dual functionalities as the additive in aqueous lubrication system Open
The polyionic liquid poly-PEGMA-r-METAC (PPM) with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids. The rheological behavior of aqueous lubricating fluids with PPM has been characterized to …
View article: Tormentic acid, a triterpenoid isolated from the fruits of <i>Chaenomeles speciose</i> , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway
Tormentic acid, a triterpenoid isolated from the fruits of <i>Chaenomeles speciose</i> , protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway Open
TA may have potential use as a clinical drug candidate for gastric mucosal lesion treatment.
View article: A simplified non-coplanar volumetric modulated arc therapy for the whole brain radiotherapy with hippocampus avoidance
A simplified non-coplanar volumetric modulated arc therapy for the whole brain radiotherapy with hippocampus avoidance Open
Purpose To evaluate the feasibility of using a simplified non-coplanar volumetric modulated arc therapy (NC-VMAT) and investigate its dosimetric advantages compared with intensity modulated radiation therapy (IMRT) and coplanar volumetric …
View article: CCDC 2217920: Experimental Crystal Structure Determination
CCDC 2217920: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Access to medicines for children in China
Access to medicines for children in China Open
Access to essential medicines for children is a big challenge, particularly in low-income and middle-income countries. In China, the average availability of essential medicines for children is 1.6%–46.5%. The availability of generics was g…
View article: Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K/AKT/mTOR Signaling Pathway
Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K/AKT/mTOR Signaling Pathway Open
Nigrosporins B, an anthraquinone derivative obtained from the secondary metabolites of marine fungus Nigrospora oryzae. In this study, we characterized the distinctive anti-cancer potential of Nigrosporins B in vitro and underlying molecul…
View article: Numerical simulation of flow pattern for non-Newtonian flow in agitated thin film evaporator
Numerical simulation of flow pattern for non-Newtonian flow in agitated thin film evaporator Open
Agitated thin film evaporator (ATFE) is a new type of high-efficiency evaporator where a film is forced to form through a rotating scraper and the high-viscosity non-Newtonian flow materials can be evaporated smoothly. The flow distributio…
View article: ATG 4B Serves a Crucial Role in RCE-4-Induced Inhibition of the Bcl-2–Beclin 1 Complex in Cervical Cancer Ca Ski Cells
ATG 4B Serves a Crucial Role in RCE-4-Induced Inhibition of the Bcl-2–Beclin 1 Complex in Cervical Cancer Ca Ski Cells Open
RCE-4, a steroidal saponin isolated from Reineckia carnea, has been studied previously and has exhibited promising anti-cervical cancer properties by inducing programmed cell death (PCD) of Ca Ski cells. Considering the cancer cells develo…
View article: Sleep Monitoring of Children With Nocturnal Enuresis: A Narrative Review
Sleep Monitoring of Children With Nocturnal Enuresis: A Narrative Review Open
The purpose of this article is to provide a succinct summary of the sleep monitoring efforts that have been used in nocturnal enuresis (NE) and an overview of the knowledge that has accrued. This is not intended to be a comprehensive revie…
View article: Friction properties of suspended graphene
Friction properties of suspended graphene Open
Minimizing friction is a goal that has long been pursued in history. The role of micro-electromechanical system and nano-electromechanical system (MEMS/NEMS) in electronic devices is becoming more and more important. Due to the increasingl…