Kun‐Ming Chen
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View article: The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity
The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity Open
Tobacco smoking (TS) is an established etiological factor in the development of head and neck squamous cell carcinoma (HNSCC). We previously developed a mouse model using a select tobacco carcinogen, dibenzo[a,l]pyrene (DB[a,l]P, and its u…
View article: An Optimized Editing Approach for Wheat Genes by Improving sgRNA Design and Transformation Strategies
An Optimized Editing Approach for Wheat Genes by Improving sgRNA Design and Transformation Strategies Open
Hexaploid wheat has a large genome, making it difficult for transgenes to produce phenotypes due to gene redundancy and tight linkage among genes. Multiple gene copies typically necessitate multiple targeting events during gene editing, fo…
View article: Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheat
Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheat Open
This study presents a comprehensive spatiotemporal transcriptional dataset for understanding wheat grain development. Additionally, it identifies key genetic resources with potential applications for improving wheat yield.
View article: NAL1 forms a molecular cage to regulate FZP phase separation
NAL1 forms a molecular cage to regulate FZP phase separation Open
NARROW LEAF 1 ( NAL1 ), originally identified for its role in shaping leaf morphology, plant architecture, and various agronomic traits in rice, has remained enigmatic in terms of the molecular mechanisms governing its multifaceted functio…
View article: Inhibition of benzo[<i>a</i>]pyrene-induced DNA adduct in buccal cells of smokers by black raspberry lozenges
Inhibition of benzo[<i>a</i>]pyrene-induced DNA adduct in buccal cells of smokers by black raspberry lozenges Open
Using LC–MS/MS analysis we previously showed for the first time (Carcinogenesis 43:746–753, 2022) that levels of DNA damage induced by benzo[a]pyrene (B[a]P), an oral carcinogen and tobacco smoke (TS) constituent, were significantly higher…
View article: Temporal-spatial transcriptomics reveals key gene regulation for grain yield and quality in wheat
Temporal-spatial transcriptomics reveals key gene regulation for grain yield and quality in wheat Open
Cereal grain size and quality are important agronomic traits in crop production. The development of wheat grains is underpinned by complex regulatory networks. The precise spatial and temporal coordination of diverse cell types is essentia…
View article: Analysis and research on the efficiency improvement mechanism of automated invoicing process of outage ticket based on queuing theory
Analysis and research on the efficiency improvement mechanism of automated invoicing process of outage ticket based on queuing theory Open
The electricity ticket system is an important basis for staff to carry out maintenance plan designation and execution. With the gradual progress of the work of the grid grassroots staff to reduce the burden, the need to simplify the proces…
View article: Revisiting the molecular mechanisms and adaptive strategies associated with drought stress tolerance in common wheat (Triticum aestivum L.)
Revisiting the molecular mechanisms and adaptive strategies associated with drought stress tolerance in common wheat (Triticum aestivum L.) Open
Drought is a misfortune for crops. Wheat is a staple crop and its sustainability and adequate supply are vital to food security around the world. The development of drought-tolerant cultivars in wheat is a major challenge to breeders, ther…
View article: Rapid alkalinization factor: function, regulation, and potential applications in agriculture
Rapid alkalinization factor: function, regulation, and potential applications in agriculture Open
Rapid alkalinization factor (RALF) is widespread throughout the plant kingdom and controls many aspects of plant life. Current studies on the regulatory mechanism underlying RALF function mainly focus on Arabidopsis, but little is known ab…
View article: Table S3 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Table S3 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Histological feature in the oral tissues of mice treated with DBP and DBP + BRB.
View article: Supplementary Table S1 from Effects of Black Raspberry on Dibenzo[<i>a,l</i>]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity
Supplementary Table S1 from Effects of Black Raspberry on Dibenzo[<i>a,l</i>]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity Open
Body weight of mice treated with DB[a,l]PDE in the absence and presence of BRB.
View article: Figure S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Figure S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
A representative H&E staining showing the histological features identified in the oral tissues of mice. The box indicates the area magnified for the inset. The inset shows epithelial hyperplasia with atypia.
View article: supp data figure legend from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells
supp data figure legend from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells Open
Legend for Supplementary Figure 1.
View article: Table S1B from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Table S1B from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Hypomethylated loci identified in oral tissues of mice treated with DBP and fed control diet or mice treated with DBP and fed 5% BRB diet.
View article: Figure S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Figure S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
A representative H&E staining showing the histological features identified in the oral tissues of mice. The box indicates the area magnified for the inset. The inset shows epithelial hyperplasia with atypia.
View article: Supp data figure 1 from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells
Supp data figure 1 from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells Open
HPLC of 5 ng DBPDE incubated in keratinocyte growth medium overnight at room temperature in the absence (lower trace) and presence of BRB extract (10 ug/ml, middle trace) or (50ug/ml, upper trace).
View article: Supplementary Data Legends from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Supplementary Data Legends from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Supplemental Data Legends for Tables and Figures
View article: Data from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Data from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
We previously reported that the environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene (DBP) induced DNA damage, altered DNA methylation and induced oral squamous cell carcinoma (OSCC) in mice. In the present study, w…
View article: Table S1A from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Table S1A from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Hypermethylated loci identified in oral tissues of mice treated with DBP and fed control diet or mice treated with DBP and fed 5% BRB diet.
View article: supp data figure legend from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells
supp data figure legend from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells Open
Legend for Supplementary Figure 1.
View article: Supp data figure 1 from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells
Supp data figure 1 from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells Open
HPLC of 5 ng DBPDE incubated in keratinocyte growth medium overnight at room temperature in the absence (lower trace) and presence of BRB extract (10 ug/ml, middle trace) or (50ug/ml, upper trace).
View article: Table S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Table S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Top canonical pathways generated using IPA® on aberrantly methylated genes identified in oral tissues of mice treated with DBP and fed control diet vs. mice treated with DBP and fed 5% BRB diet.
View article: Table S3 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Table S3 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Histological feature in the oral tissues of mice treated with DBP and DBP + BRB.
View article: Figure S1 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Figure S1 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Analysis of methylation data obtained by ERRBS in oral tissues of mice treated with DBP and fed control diet vs. mice treated with DBP and fed 5% BRB diet. (A) Differential methylation annotation. (B) Unsupervised analysis of DNA methylati…
View article: Data from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells
Data from Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells Open
Effects of black raspberry (BRB) extract and protocatechuic acid (PCA) on DNA adduct formation and mutagenesis induced by metabolites of dibenzo[a,l]pyrene (DBP) were investigated in rat oral fibroblasts. The DBP metabolites, (±)-anti-11,1…
View article: Supplementary Data Legends from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Supplementary Data Legends from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
Supplemental Data Legends for Tables and Figures
View article: Data from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Data from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations Open
We previously reported that the environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene (DBP) induced DNA damage, altered DNA methylation and induced oral squamous cell carcinoma (OSCC) in mice. In the present study, w…
View article: Supplementary Table S1 from Effects of Black Raspberry on Dibenzo[<i>a,l</i>]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity
Supplementary Table S1 from Effects of Black Raspberry on Dibenzo[<i>a,l</i>]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity Open
Body weight of mice treated with DB[a,l]PDE in the absence and presence of BRB.