Kang Zhou
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View article: Prevalence and risk factors of oral frailty in elderly cancer inpatients: A cross-sectional study
Prevalence and risk factors of oral frailty in elderly cancer inpatients: A cross-sectional study Open
This study aimed to investigate the prevalence of oral frailty (OF) and identify factors associated with it among elderly cancer inpatients. A cross-sectional study was conducted in a tertiary hospital in Wuhu City, Anhui Province, China, …
View article: Perioperative glycemic fluctuations mediate the association between BMI and postoperative acute kidney injury in patients undergoing cardiac surgery: a retrospective cohort study
Perioperative glycemic fluctuations mediate the association between BMI and postoperative acute kidney injury in patients undergoing cardiac surgery: a retrospective cohort study Open
Background: Perioperative glucose fluctuations are a common complication of cardiac surgery, and acute kidney injury (AKI) is a serious complication after cardiac surgery. Body Mass Index (BMI) is associated with postoperative AKI, and BMI…
View article: Immunotherapy-Based Strategies versus Transcatheter Arterial Chemoembolization and the Impact of Treatment Duration in Hepatocellular Carcinoma with Microvascular Invasion: A Retrospective Multicenter Cohort Study
Immunotherapy-Based Strategies versus Transcatheter Arterial Chemoembolization and the Impact of Treatment Duration in Hepatocellular Carcinoma with Microvascular Invasion: A Retrospective Multicenter Cohort Study Open
Among patients with HCC and MVI following curative resection, adjuvant ICIs therapy provides a significant recurrence-free survival advantage over TACE. Treatment durations shorter than 12 months may be insufficient, supporting the benefit…
View article: Comparison of oliceridine and sufentanil in patient - controlled intravenous analgesia for post - thoracoscopic nausea and vomiting: a prospective, double - blind, randomized controlled trial
Comparison of oliceridine and sufentanil in patient - controlled intravenous analgesia for post - thoracoscopic nausea and vomiting: a prospective, double - blind, randomized controlled trial Open
Objective To compare oliceridine and sufentanil in patient-controlled intravenous analgesia (PCIA) for reducing postoperative nausea and vomiting (PONV) in thoracoscopic surgery patients. Methods A prospective, double-blind, randomized con…
View article: Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China
Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China Open
Luspatercept demonstrated efficacy and safety in Chinese LR-MDSSF3B1 patients. Greater erythroid hyperplasia correlated with better clinical response.
View article: Immune cell phenotypes and eating disorders: To find causal relationship through Mendelian randomization study
Immune cell phenotypes and eating disorders: To find causal relationship through Mendelian randomization study Open
Background: Eating disorders are potentially persistent mental illnesses that can lead to death. Our study is determined to found out the casual relationship between immune cell phenotypes and eating disorders via Mendelian randomization (…
View article: Efficacy and Safety of Avatrombopag in Combination with Standard Immunosuppressive Therapy for Severe Aplastic Anemia
Efficacy and Safety of Avatrombopag in Combination with Standard Immunosuppressive Therapy for Severe Aplastic Anemia Open
Background: Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disease. The addition of eltrombopag to immunosuppressive therapy (IST) improves the response rate and response quality of SAAs, but its hepatotoxicity is c…
View article: Luspatercept enhances hemoglobin levels in a Chinese boy with congenital sideroblastic anemia: A case report
Luspatercept enhances hemoglobin levels in a Chinese boy with congenital sideroblastic anemia: A case report Open
BACKGROUND Congenital sideroblastic anemia (CSA) is a rare and heterogeneous group of genetic disorders. Conventional treatment include pyridoxine (vitamin B6) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), and can all…
View article: Modulation instability of whistler wave with electron loss cone distribution in magnetized plasma
Modulation instability of whistler wave with electron loss cone distribution in magnetized plasma Open
The modulation instability of whistler mode waves caused by thermal electron anisotropy is studied. Based on MHD equations, the nonlinear schr\"{o}dinger equation (NLSE) that describes the nonlinear modulation of whistler waves is derived …
View article: Cardiopulmonary Protection of Modified Remote Ischemic Preconditioning in Mitral Valve Replacement Surgery: A Randomized Controlled Trial
Cardiopulmonary Protection of Modified Remote Ischemic Preconditioning in Mitral Valve Replacement Surgery: A Randomized Controlled Trial Open
Background: Remote ischemic preconditioning (RIPC) is reported to have early‐phase and delayed‐phase organ‐protective effects. Previous studies have focused on the organ protection of a single RIPC protocol, and the clinical outcomes remai…
View article: IST Combined with Full-Dose Rhtpo in the Treatment of Severe Aplastic Anemia -a Prospective Single-Center Clinical Study
IST Combined with Full-Dose Rhtpo in the Treatment of Severe Aplastic Anemia -a Prospective Single-Center Clinical Study Open
BACKGROUND: Immunosuppressive therapy (IST) (anti-thymocyte immunoglobulin (ATG) and cyclosporine (CSA)) is the treatment of choice for patients with acquired severe aplastic anemia (SAA) who are ineligible for hematopoietic stem cell tran…
View article: Development and validation of early death risk score model for emergency status prediction in very severe aplastic anemia
Development and validation of early death risk score model for emergency status prediction in very severe aplastic anemia Open
This study developed and validated the Early Death Risk Score Model for early identification of emergency patients with very severe aplastic anemia (VSAA). All 377 patients with VSAA receiving first-line immunosuppressive therapy (IST) wer…
View article: [Clinical and gene mutation characteristics of patients with hereditary ellipsocytosis: nine cases report and literature review].
[Clinical and gene mutation characteristics of patients with hereditary ellipsocytosis: nine cases report and literature review]. Open
Objective: To report gene mutations in nine patients with hereditary elliptocytosis (HE) and analyze the characteristics of pathogenic gene mutations in HE. Methods: The clinical and gene mutations of nine patients clinically diagnosed wit…
View article: [Metagenomic next-generation sequencing of plasma for the identification of bloodstream infectious pathogens in severe aplastic anemia].
[Metagenomic next-generation sequencing of plasma for the identification of bloodstream infectious pathogens in severe aplastic anemia]. Open
Objective: To analyze the diagnostic value of cell-free plasma metagenomic next-generation sequencing (mNGS) pathogen identification for severe aplastic anemia (SAA) bloodstream infection. Methods: From February 2021 to February 2022, mNGS…
View article: [The effect of on-demand glucocorticoid strategy on the occurrence and outcome of p-ALG-associated serum sickness in aplastic anemia].
[The effect of on-demand glucocorticoid strategy on the occurrence and outcome of p-ALG-associated serum sickness in aplastic anemia]. Open
Objective: To investigate the effect of on-demand glucocorticoid strategy on the occurrence and outcome of porcine anti-lymphocyte globulin (p-ALG) -associated serum sickness in aplastic anemia (AA) . Methods: The data of AA patients who r…
View article: Genotype-Degree of hemolysis Correlation in Hereditary Spherocytosis
Genotype-Degree of hemolysis Correlation in Hereditary Spherocytosis Open
Objective: To investigate the potential genotype-degree of hemolysis association in hereditary spherocytosis (HS). Methods: 23 HS patients in our cohort all conducted next-generation sequencing (NGS) to detect erythrocyte membrane protein …
View article: Hetrombopag plus porcine ATG and cyclosporine for the treatment of aplastic anaemia: early outcomes of a prospective pilot study
Hetrombopag plus porcine ATG and cyclosporine for the treatment of aplastic anaemia: early outcomes of a prospective pilot study Open
Hetrombopag, a small molecular thrombopoietin-receptor agonist, has shown encouraging efficiency in immunosuppressive therapy refractory or relapsed severe aplastic anaemia. To investigate the response rate of hetrombopag combined with IST…
View article: Efficacy of eltrombopag with immunosuppressive therapy for children with acquired aplastic anemia
Efficacy of eltrombopag with immunosuppressive therapy for children with acquired aplastic anemia Open
Background Eltrombopag (EPAG), an oral thrombopoietin receptor agonist (TPO-RA), has been proven to improve the hematologic response without increasing toxic effects as a first-line therapy combined with standard immunosuppressive treatmen…
View article: Local-regional therapy combined with toripalimab and lenvatinib in patients with advanced biliary tract cancer.
Local-regional therapy combined with toripalimab and lenvatinib in patients with advanced biliary tract cancer. Open
Local-regional therapy combined with PD-1 inhibitors and lenvatinib (triple combination therapy) has demonstrated potent antitumor activity in solid tumors. However, the efficacy and safety of the triple combination therapy in patients wit…
View article: Antihuman T lymphocyte porcine immunoglobulin combined with cyclosporine as first-line immunosuppressive therapy for severe aplastic anemia in China: a large single-center, 10-year retrospective study
Antihuman T lymphocyte porcine immunoglobulin combined with cyclosporine as first-line immunosuppressive therapy for severe aplastic anemia in China: a large single-center, 10-year retrospective study Open
Background: Antihuman T lymphocyte porcine immunoglobulin (p-ATG) has been the most common ATG preparation in immunosuppressive therapy (IST) in Chinese patients with severe aplastic anemia (SAA) since 2009. Objectives: This study aimed to…
View article: [Hematologic responses to avatrombopag switch in TPO-RA refractory aplastic anemia].
[Hematologic responses to avatrombopag switch in TPO-RA refractory aplastic anemia]. Open
Objective: Short-term efficacy and safety of afatrombopag conversion therapy in patients with aplastic anemia (AA) who were previously ineffectively treated with intense immunosuppressive therapy (IST) combined with TPO receptor Agonist (T…
View article: [Reassessing the six months prognosis of patients with severe or very severe aplastic anemia without hematological responses at three months after immunosuppressive therapy].
[Reassessing the six months prognosis of patients with severe or very severe aplastic anemia without hematological responses at three months after immunosuppressive therapy]. Open
Objective: To reassess the predictors for response at 6 months in patients with severe or very severe aplastic anemia (SAA/VSAA) who failed to respond to immunosuppressive therapy (IST) at 3 months. Methods: We retrospectively analyzed the…