Explanipedia

Prevalence of HPV Positivity and the Correlation Between P16INK4A Expression and HPV DNA Positivity in Carcinoma Oropharynx and Their Correlation With Survival Outcomes: A Retrospective Study From a Tertiary Cancer Centre in South India Open

Ping Ao, Lekha Nair, Rejnish Ravikumar, Preethi Sara George, C.T. Kainickal , et al. · 2025

Efficacy of a herbal mouthwash for management of periodontitis and radiation-induced mucositis – A consolidated report of two randomized controlled clinical trials Open

R. Ambili, Kunnambath Ramadas, Lekha Nair, Divya Raj, Farida Nazeer , et al. · 2023

For Study 1: CTRI/2019/10/021574, Study 2: CTRI/2020/04/024851.

Carcinoma buccal mucosa treated with definitive hypofractionated accelerated radiotherapy: a retrospective analysis of treatment outcomes Open

Geethu Babu, Rejnish Ravikumar, Malu Rafi, Zuzaki Sharafuddin, S Arun Shankar , et al. · 2023

Introduction: Oral cancer is a major public health concern in India. Both conventional and altered fractionation radiotherapy schedules have been used in curative treatment of oral cancer. This study aimed to retrospectively evaluate the c…

Epstein–Barr virus dynamics and its prognostic impact on nasopharyngeal cancers in a non-endemic region Open

Rajitha Ganipathi, Kannan Sankara Reddiar, Kunnambath Ramadas · 2022

Plasma EBV DNA is an accurate and reliable biomarker for NPC for WHO type 2 and 3 tumours even in non-endemic regions.

Outcomes of organ preservation treatment in advanced laryngeal carcinoma: A retrospective analysis from a single institution Open

Afsar Fasaludeen, Rejnish Kumar, Malu Rafi, Farida Nazeer, Aparna Mullangath Prakasan , et al. · 2022

Chemoradiation is the standard treatment for patients with locally advanced laryngeal carcinoma with intact cartilage and functional larynx. The aim of this retrospective study was to assess overall survival (OS) and disease-free survival …

Effectiveness of triennial screening with clinical breast examination: 14‐years follow‐up outcomes of randomized clinical trial in Trivandrum, India Open

Kunnambath Ramadas, Partha Basu, Beela S. Mathew, Richard Muwonge, Venugopal Muraleedharan , et al. · 2022

Background This study presents the preliminary results of a randomized controlled trial (RCT) initiated in January 2006 in India to evaluate the effectiveness of clinical breast examination (CBE) in reducing breast cancer mortality as comp…

IARC Perspective on Oral Cancer Prevention Open

Véronique Bouvard, Suzanne Tanya Nethan, Deependra Singh, Saman Warnakulasuriya, Ravi Mehrotra , et al. · 2022

In 2020, cancer of the lip and oral cavity was estimated to rank 16th in incidence and mortality worldwide and was a common cause of cancer death in men across much of South and Southeast Asia and the Western Pacific. A wide range of genet…

Accuracy of high-risk HPV DNA PCR, p16(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer Open

Cindy Simoens, Tarik Gheit, Ruediger Ridder, Ivana Gorbašlieva, Dana Holzinger , et al. · 2022

Background The incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing in high-resource countries. Patients with HPV-induced cancer respond …

Three-week hypofractionated radiotherapy in early glottic cancer – a single institution retrospective study Open

A.S. Sudha, Ravikumar Rejnish Kumar, Milan Anjanappa, Cessal Thomas Kainickal, Aleyamma Mathew , et al. · 2022

In early glottic cancer, hypofractionated radiation provides excellent local control.Subglottic extension is a poor prognostic factor.5-year disease-free survival rate of 96.1%.5-year functional larynx preservation rate of 94.9%.Severe com…

Clinical Profile and Treatment Outcomes in Patients Treated with Intensity-Modulated Radiotherapy (IMRT) for Carcinoma Nasopharynx: A Retrospective Analysis Open

Farida Nazeer, Raghu Kumar, Malu Rafi, Tapesh Bhattacharya, Aparna Mullangath Prakasan , et al. · 2021

Objective. To retrospectively evaluate the clinical outcome of carcinoma nasopharynx patients treated with the IMRT technique. Methods. Eighty-one nasopharyngeal carcinoma patients who were treated with IMRT with or without chemotherapy be…

Role of Organ Preservation in Locally Advanced Hypopharyngeal Carcinoma Open

Farida Nazeer, Rejnish Kumar, Malu Rafi, Lekha Nair, C.T. Kainickal , et al. · 2021

Hypopharyngeal carcinoma is relatively rare and has the worst prognosis of all head and neck cancers. Initially, surgery followed by postoperative radiation was the standard of care for locally advanced disease. In the recent years, variou…

Chemotherapy in Nasopharyngeal Carcinoma Open

Lekha Nair, Rejnish Kumar, Malu Rafi, Farida Nazeer, C.T. Kainickal , et al. · 2021

Nasopharyngeal carcinoma is a unique disease entity among head and neck cancers due to its epidemiology and clinical behavior. Non-keratinizing or undifferentiated carcinoma is the most common histological type in endemic areas. Radiothera…

Human Papillomavirus Associated Oropharyngeal Carcinoma-Diagnosis and Management Open

Mullangath Prakasan Aparna, Ravi Rejnish Kumar, Malu Rafi, Geethu Babu, Pradeep Kumar , et al. · 2021

Head and neck squamous cell carcinomas arise from the mucosa of the upper aerodigestive tract and is often driven by risk factors like tobacco and alcohol consumption. Most of the time patients present with locally advanced stages and the …

Risk-Based Selection of Individuals for Oral Cancer Screening Open

Li C. Cheung, Kunnambath Ramadas, Richard Muwonge, Hormuzd A. Katki, Gigi Thomas , et al. · 2021

PURPOSE: We evaluated proof of principle for resource-efficient, risk-based screening through reanalysis of the Kerala Oral Cancer Screening Trial. METHODS: The cluster-randomized trial included three triennial rounds of visual inspection …

Educational Status, Cancer Stage, and Survival in South India: A Population-Based Study Open

Aleyamma Mathew, Preethi Sara George, Kunnambath Ramadas, Beela Sarah Mathew, Aswin Kumar , et al. · 2020

PURPOSE Lower socioeconomic status is associated with more advanced cancer at the time of cancer diagnosis. It is unknown whether this leads to inferior survival in low- and middle-income countries. Here, we explore the association between…

Sociodemographic Factors and Stage of Cancer at Diagnosis: A Population-Based Study in South India Open

Aleyamma Mathew, Preethi Sara George, Kunnambath Ramadas, Beela Sarah Mathew, Aswin Kumar , et al. · 2019

PURPOSE Lower socioeconomic status is associated with inferior cancer survival in high-income countries, but whether this applies to low- and middle-income countries is not well described. Here, we use a population-based cancer registry to…

Sinonasal nonsalivary-type adenocarcinoma: A 9-year experience from a tertiary cancer center in South India Open

KR Anila, Kunnambath Ramadas, ElizabethMathew Iype, TR Preethi, Anitha Mathews , et al. · 2019

Background: Sinonasal tract malignancies are uncommon, representing not more than 5% of all head and neck neoplasm. Primary non-salivary type adenocarcinomas of the sinonasal tract are rare and may originate from respiratory surface epithe…

Targeted Therapy in Recurrent or Metastatic Head and Neck Carcinoma Open

Kunnambath Ramadas, C.T. Kainickal, Aparna MP, Rejnish Kumar, Malu Rafi · 2018

This review article is trying to high light the current evidence to support the use of targeted therapy for the best management practices for patients with recurrent and/ or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).Pl…

Setup uncertainties and PTV margins at different anatomical levels in intensity modulated radiotherapy for nasopharyngeal cancer Open

Milan Anjanappa, Malu Rafi, Saju Bhasi, Rejnish Kumar, C.T. Kainickal , et al. · 2017

AIM: To determine the systematic error (∑), random error (σ) and derive PTV margin at different levels of the target volumes in Nasopharyngeal Cancer (NPC). MATERIALS AND METHODS: A retrospective offline review was done for patients who un…

Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis Open

Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire , et al. · 2017

Phase IIb trial comparing two concurrent cisplatin schedules in locally advanced head and neck cancer Open

Lekha Nair, R. Rejnish Kumar, Kainickal Cessal Thomachan, Malu Rafi, Preethi Sara George , et al. · 2017

Background: Concurrent chemoradiation with 3 weekly cisplatin (100 mg/m2) is the standard of care for locally advanced head and neck cancer. However, this regimen has been shown to be associated with lesser compliance and higher toxicities…

Current Status of Anti Epidermal Growth Factor Receptor Therapy in the Curative Treatment of Head and Neck Squamous Cell Carcinoma Open

C.T. Kainickal, Mullangath Prakasan Aparna, Rejnish Kumar Ravi Kumar, Malu Rafi, Kunnambath Ramadas · 2017

Squamous cell carcinoma of head and neck is the most common malignancy of the upper aero digestive tract in the world.In this article, we attempt to summarize the role of antiepidermal growth factor therapy (EGFR) in the treatment of local…

Oral Cancer: Prevention, Early Detection, and Treatment Open

Rengaswamy Sankaranarayanan, Kunnambath Ramadas, Hemantha Amarasinghe, Sujha Subramanian, Newell W. Johnson · 2015

Oral cancer is the 11th most common cancer in the world, accounting for an estimated 300,000 new cases and 145,000 deaths in 2012 and 702,000 prevalent cases over a period of five years (old and new cases) (tables 5.1 and 5.2) (Bray and ot…

Associations of Body Mass Index, Smoking, and Alcohol Consumption With Prostate Cancer Mortality in the Asia Cohort Consortium Open

Jay H. Fowke, Dale McLerran, Prakash C. Gupta, Jiang He, Xiao‐Ou Shu , et al. · 2015

Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)(…

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