Explanipedia

Association between <i>IL-6</i> gene polymorphisms and susceptibility to Parkinson’s disease Open

Jinzhao Gao, Zihan Wang, Kunpeng Qin, Yiping Wang, Qiqing He , et al. · 2025

The rs1800796 polymorphism of the IL-6 gene may be associated with susceptibility to PD in the northern Chinese Han population.

Toxoplasma TgCtwh3 Δrop16 accelerates neuronal apoptosis and APP production in mouse with acute infection Open

Di Yang, Cong Wang, Qing Tao, Lei Liu, Mengmeng Jin , et al. · 2025

A novel nanomedicine for osteosarcoma treatment: triggering ferroptosis through GSH depletion and inhibition for enhanced synergistic PDT/PTT therapy Open

Tangbing Xu, Qiming Ma, Chi Zhang, Xiaoyan He, Qian Wang , et al. · 2025

Association of hematological parameters and inflammatory indices with sarcopenia in the United States and China: a cross-sectional study Open

Ying Cheng, Kuang Chen, Gang Zhang, Zhongzheng Zhang, Kunpeng Qin · 2025

A Novel Nanomedicine for Osteosarcoma Treatment: Triggering Ferroptosis through GSH Depletion and Inhibition for Enhanced Synergistic PDT/PTT Therapy Open

Tangbing Xu, Qiming Ma, Chi Zhang, Xiaoyan He, Qian Wang , et al. · 2024

Osteosarcoma treatment remains challenging due to the limitations of single-modality therapies.To address this, we designed a carrier-free nanomedicine [email protected]@IR780 (CSIR) for synergistic ferroptosis, photodynamic therapy (PDT), an…

WITHDRAWN: Effects of TgCtwh3 Toxoplasma gondii ROP16 on neuronal apoptosis and β-amyloid production Open

Di Yang, Cong Wang, Qing Tao, Lei Liu, Mengmeng Jin , et al. · 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

TMEM106B Knockdown Exhibits a Neuroprotective Effect in Parkinson’s Disease via Decreasing Inflammation and Iron Deposition Open

Yumei Liu, Kunpeng Qin, Chunyan Jiang, Jinzhao Gao, Binghui Hou , et al. · 2024

Parkinson’s disease (PD) is closely related to iron accumulation and inflammation. Emerging evidence indicates that TMEM106B plays an essential role in PD. But whether TMEM106B could act on neuroinflammation and iron metabolism in PD has n…

Knockdown of DJ-1 Exacerbates Neuron Apoptosis Induced by TgCtwh3 through the NF-κB Pathway Open

Di Yang, Minmin Wu, Nian Zou, Yiru Tang, Qing Tao , et al. · 2024

Mutations or loss of function of DJ-1 and Toxoplasma gondii ( T. gondii ) infection has been linked to neurodegenerative diseases, which are often caused by oxidative stress. However, the relationship between DJ-1 and T. gondii infection i…

WITHDRAWN: Effects of TgCtwh3 Toxoplasma gondii ROP16 on neuronal apoptosis and β-amyloid production Open

Di Yang, Cong Wang, Qing Tao, Lei Liu, Mengmeng Jin , et al. · 2023

Background Toxoplasma gondii ( T.gondii ) has been demonstrated to be a causative agent of Alzheimer's disease (AD). Neuronal apoptosis and β-amyloid (Aβ) aggregation are some of the main pathological features of AD. In recent years, our g…

Studies on the mechanism of Toxoplasma gondii Chinese 1 genotype Wh6 strain causing mice abnormal cognitive behavior Open

Qing Tao, Di Yang, Kunpeng Qin, Lei Liu, Mengmeng Jin , et al. · 2023

3,3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy Open

Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang , et al. · 2022

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in particular, inflammation, autophagy, and apoptosis are often involved. 3,3-Diindolylm…

Erythropoietin inhibits ferroptosis and ameliorates neurological function after spinal cord injury Open

Zongsheng Yin, Yu Kang, Rui Zhu, Shuang Li, Kunpeng Qin , et al. · 2022

Ferroptosis is one of the critical pathological events in spinal cord injury. Erythropoietin has been reported to improve the recovery of spinal cord injury. However, whether ferroptosis is involved in the neuroprotective effects of erythr…

Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes Open

Kunpeng Qin, Hao Tang, Yi Ren, Di Yang, Yetian Li , et al. · 2022

Osteoarthritis (OA) is the most common chronic disease characterized by a loss of chondrocytes and the degeneration of cartilage. Inflammation plays an important role in the pathogenesis and progression of OA via the activation of the endo…

Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism Open

Meilan Xue, Hui Liang, Zhitong Zhou, Ying Liu, Xinjia He , et al. · 2021

Fucoidan inhibited alcohol-induced steatosis and disorders of bile acid metabolism in mice through the AMPKα1/SIRT1 pathway and the gut microbiota-bile acid-liver axis and protected against alcohol-induced liver injury in vivo.

The New Role of Sirtuin1 in Human Osteoarthritis Chondrocytes by Regulating Autophagy Open

Faxue Liao, Fei Huang, Wen-Guang Ma, Kunpeng Qin, Pengfei Xu , et al. · 2019

Objective The aim of this study is to investigate the role of Sirtuin1 (Sirt1) in the regulation of autophagy for human osteoarthritis (OA) chondrocytes. Design All cartilage samples were collected from human donors, including young group,…

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