Kunpeng Wang
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View article: UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis
UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis Open
Chronic pancreatitis (CP) is a progressive inflammatory disease characterized by pancreatic fibrosis and functional decline. Here, we identify macrophage‐to‐myofibroblast transition (MMT) as a novel feature of CP and investigate the role o…
View article: Mechanism of action of <i>Aloe vera</i> against human papillomavirus‑positive head and neck squamous cell carcinoma
Mechanism of action of <i>Aloe vera</i> against human papillomavirus‑positive head and neck squamous cell carcinoma Open
The present study aimed to evaluate the therapeutic targets of Aloe vera against human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC), focusing on key bioactive components and their impact on…
View article: Suhexiang pills inhibit ischemia stroke via targeting miR-24–3p to promote the activation of Keap1/Nrf2 signaling pathway
Suhexiang pills inhibit ischemia stroke via targeting miR-24–3p to promote the activation of Keap1/Nrf2 signaling pathway Open
View article: Clock genes in pancreatic disease progression: from circadian regulation to dysfunction
Clock genes in pancreatic disease progression: from circadian regulation to dysfunction Open
Circadian clock genes play a multifaceted role in pancreatic disease pathophysiology, extending beyond metabolic regulation to influence immune responses, inflammation, and tumorigenesis. Understanding these mechanisms may inform the devel…
View article: Nodular networks in hydrated polyamide desalination membranes enhance water transport
Nodular networks in hydrated polyamide desalination membranes enhance water transport Open
For nearly half a century, thin-film composite reverse osmosis membranes have served as key separation materials for desalination. However, the precise structure of their polyamide selective layer under hydrated conditions and its relation…
View article: Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure
Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure Open
Prenatal exposure to glucocorticoids is linked to long‐term health risks in offspring, but the role of maternal gut microbiota in mediating these effects remains unclear. Here, we demonstrate that prenatal prednisone therapy (PPT) in human…
View article: Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis
Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis Open
Severe acute pancreatitis (SAP) is a life-threatening abdominal condition often complicated by intestinal barrier dysfunction, which further exacerbates disease progression. Neferine has demonstrated potent anti-inflammatory and antioxidan…
View article: Abdominal tuberculosis with pancreatic head involvement mimicking pancreatic malignancy in a young man: A case report
Abdominal tuberculosis with pancreatic head involvement mimicking pancreatic malignancy in a young man: A case report Open
BACKGROUND Pancreatic tuberculosis (PTB) is a rare disease, even in immunocompetent hosts. Abdominal tuberculosis involving the pancreatic head and peripancreatic areas may simulate pancreatic head carcinoma. CASE SUMMARY We present the ca…
View article: The Efficacy and Safety of Chimeric Antigen Receptor-T Cell Therapy in Solid Malignancies: A Systematic Review and Meta-Analysis
The Efficacy and Safety of Chimeric Antigen Receptor-T Cell Therapy in Solid Malignancies: A Systematic Review and Meta-Analysis Open
View article: Indoor airborne carcinogen synergy in children: systematic interdisciplinary approach to PM2.5-nicotine driven lung tumorigenesis and targeted intervention
Indoor airborne carcinogen synergy in children: systematic interdisciplinary approach to PM2.5-nicotine driven lung tumorigenesis and targeted intervention Open
View article: Two-step localization driven by peptidoglycan hydrolase in interbacterial predation
Two-step localization driven by peptidoglycan hydrolase in interbacterial predation Open
Mechanisms of bacterial predation are crucial for revealing microbial adaptation strategies and interaction behaviors in the environment, yet they remain poorly understood. Previously, predators were reported to localize prey via specific …
View article: Nonlinear Vibrations of a Dual-Rotor-Bearing System with Blade-Tip Aerodynamic Excitation
Nonlinear Vibrations of a Dual-Rotor-Bearing System with Blade-Tip Aerodynamic Excitation Open
View article: Body composition as a prognostic factor in cholangiocarcinoma: a meta-analysis
Body composition as a prognostic factor in cholangiocarcinoma: a meta-analysis Open
This investigation seeks to scrutinize the relationships between body composition metrics and the clinical outcomes observed in patients with cholangiocarcinoma (CCA). A comprehensive exploration was conducted across three prominent online…
View article: Stem cell exosomes: new hope and future potential for relieving liver fibrosis
Stem cell exosomes: new hope and future potential for relieving liver fibrosis Open
Liver fibrosis is a chronic liver injury resulting from factors like viral hepatitis, autoimmune hepatitis, non-alcoholic steatohepatitis, fatty liver disease, and cholestatic liver disease. Liver transplantation is currently the gold stan…
View article: Prognostic impact of body composition in hepatocellular carcinoma patients with immunotherapy
Prognostic impact of body composition in hepatocellular carcinoma patients with immunotherapy Open
The presence of sarcopenia and low SMI in HCC patients undergoing treatment with ICIs was found to be related to inferior treatment response and reduced long-term effectiveness.
View article: Simple and effective: Superlubricity behaviour of the G-quadruplex hydrogel with high selectivity for K+ ions based on the ocular environment
Simple and effective: Superlubricity behaviour of the G-quadruplex hydrogel with high selectivity for K+ ions based on the ocular environment Open
Hydrogels have been the subject of significant research in the field of friction due to their exceptional lubricating properties. In this study, the G-quadruplex hydrogel with high selectivity for K + ions was formed by introducing a mixtu…
View article: A nomogram model for predicting postoperative prognosis in patients with aneurysmal subarachnoid hemorrhage using preoperative biochemical indices
A nomogram model for predicting postoperative prognosis in patients with aneurysmal subarachnoid hemorrhage using preoperative biochemical indices Open
View article: Corrigendum to ‘Effective strategies to enhance the diagnosis and treatment of RCC: The application of biocompatible materials’ [Mater. Today Bio 27 (2024) 101149]
Corrigendum to ‘Effective strategies to enhance the diagnosis and treatment of RCC: The application of biocompatible materials’ [Mater. Today Bio 27 (2024) 101149] Open
[This corrects the article DOI: 10.1016/j.mtbio.2024.101149.].
View article: Effective strategies to enhance the diagnosis and treatment of RCC: The application of biocompatible materials
Effective strategies to enhance the diagnosis and treatment of RCC: The application of biocompatible materials Open
View article: Influence of body fat tissue on outcomes in patients undergoing hepatectomy or liver transplantation: a systematic review and meta-analysis
Influence of body fat tissue on outcomes in patients undergoing hepatectomy or liver transplantation: a systematic review and meta-analysis Open
Objective: The purpose of this study is to investigate potential associations between body fat composition and postoperative outcomes in patients with hepatectomy or liver transplantation. Methods: Three online databases, including Embase,…
View article: Friction injury of the central vein caused by catheter for hemodialysis: an in vitro study
Friction injury of the central vein caused by catheter for hemodialysis: an in vitro study Open
View article: Experimental Study of Autologous Platelet-rich Plasma Combined With Sodium Hyaluronate on Tendon-bone Healing After Rotator Cuff Injury Repair in Rabbits.
Experimental Study of Autologous Platelet-rich Plasma Combined With Sodium Hyaluronate on Tendon-bone Healing After Rotator Cuff Injury Repair in Rabbits. Open
The combination of PRP and sodium hyaluronate effectively promotes the repair of rotator cuff injuries and accelerates tendon-bone healing.
View article: Identification of diagnostic biomarkers for osteoarthritis through bioinformatics and machine learning
Identification of diagnostic biomarkers for osteoarthritis through bioinformatics and machine learning Open
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage degradation, inflammatory arthritis, and joint dysfunction. Currently, there is a lack of effective early diagnostic methods and treatment strategies …
View article: Pan-immune inflammation value as a prognostic biomarker for cancer patients treated with immune checkpoint inhibitors
Pan-immune inflammation value as a prognostic biomarker for cancer patients treated with immune checkpoint inhibitors Open
Background Immune checkpoint inhibitors (ICIs) represent a paradigm shift in the development of cancer therapy. However, the improved efficacy of ICIs remains to be further investigated. We conducted a systematic review and meta-analysis t…
View article: Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1
Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1 Open
Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own, but the mortality rate dramatically increases when it progresses to severe acute pancreatitis (SAP). In this study, we investigated the molecular mec…
View article: Nrf2-Dependent Hepatoprotective Effect of Ellagic Acid in Titanium Dioxide Nanoparticles-Induced Liver Injury
Nrf2-Dependent Hepatoprotective Effect of Ellagic Acid in Titanium Dioxide Nanoparticles-Induced Liver Injury Open
View article: Neuroprotective effect of sulforaphane on hyperglycemia-induced cognitive dysfunction through the Nrf2/HO-1 pathway
Neuroprotective effect of sulforaphane on hyperglycemia-induced cognitive dysfunction through the Nrf2/HO-1 pathway Open
SFN ameliorated diabetes-induced cognitive dysfunction by activating the Nrf2/HO-1 pathway, providing a new perspective for SFN therapy to delay cognitive impairment in diabetes patients.
View article: High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers
High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers Open
Sarcopenia has been considered an adverse prognostic factor in cancer patients. Intramuscular adipose tissue content, as a new marker of sarcopenia, can effectively reflect skeletal muscle quality. The aim of this study was performed to ev…
View article: Low geriatric nutritional risk index as a poor prognostic biomarker for immune checkpoint inhibitor treatment in solid cancer
Low geriatric nutritional risk index as a poor prognostic biomarker for immune checkpoint inhibitor treatment in solid cancer Open
Objective In this investigation, we focused on the geriatric nutritional risk index (GNRI), a comprehensive metric that takes into account the patient’s ideal weight, actual weight, and serum albumin levels to measure malnutrition. Our pri…
View article: Prognostic significance of the controlling nutritional status score in patients with biliary tract cancer
Prognostic significance of the controlling nutritional status score in patients with biliary tract cancer Open
Background: Numerous studies have demonstrated the significance of assessing nutritional status, commonly referred to as Controlling Nutritional Status (CONUT), in predicting the prognostic outcomes of diverse malignancies. Nevertheless, i…