Kuo-Ting Ho
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View article: Exploration of the correlation between metabolic dysfunction-associated steatotic liver disease and the FAM19A5 factor: A multivariate linear regression analysis
Exploration of the correlation between metabolic dysfunction-associated steatotic liver disease and the FAM19A5 factor: A multivariate linear regression analysis Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder characterized by liver fat accumulation. Family with sequence similarity 19 member A5 (FAM19A5), a cytokine involved in metabolic regulation…
View article: Sodium glucose co-transporter 2 inhibitor prevents nephrolithiasis in non-diabetes by restoring impaired autophagic flux
Sodium glucose co-transporter 2 inhibitor prevents nephrolithiasis in non-diabetes by restoring impaired autophagic flux Open
This research was funded by grants from the National Science and Technology Council, Taiwan (110-2314-B-006-023, 110-2320-B-006-017MY3, and 112-2314-B-006-058) and the research grants (NCKUH-11202005, -11210020) from the National Cheng Kun…
View article: Curcumin Prevents Free Fatty Acid-Induced Lipid Accumulation <i>via</i> Targeting the miR-22-3p/<i>CRLS1</i> Pathway in HepG2 Cells
Curcumin Prevents Free Fatty Acid-Induced Lipid Accumulation <i>via</i> Targeting the miR-22-3p/<i>CRLS1</i> Pathway in HepG2 Cells Open
Dysregulated lipid metabolism in liver is an important hallmark of non-alcoholic fatty liver disease (NAFLD), which may be modulated by dietary polyphenols or microRNAs (miRNAs). However, the underlying epigenetic regulatory mechanism of p…
View article: Curcumin Protects Pheochromocytoma Cells Against Hydrogen Peroxide-Induced Oxidative Stress
Curcumin Protects Pheochromocytoma Cells Against Hydrogen Peroxide-Induced Oxidative Stress Open
Objective: Oxidative stress represents a characteristic of neurodegenerative diseases, which may be alleviated by the functional food component—curcumin. However, the underlying mechanism remains unclear. The current study aimed to address…
View article: MiR-22-3p modulated the antioxidant activity of curcumin via targeting the cardiolipin synthase gene CRLS1 in LO2 cells
MiR-22-3p modulated the antioxidant activity of curcumin via targeting the cardiolipin synthase gene CRLS1 in LO2 cells Open
The antioxidant activity of curcumin has been extensively investigated for years. However, its molecular function mechanism remained unclear. Our preliminary study showed that curcumin downregulated miR-22-3p expression. This study aimed t…
View article: Characterization of Obesity-associated Long Noncoding RNAs in Lung
Characterization of Obesity-associated Long Noncoding RNAs in Lung Open
Obesity often increases the risk of cancer and worsens the prognosis. Unlike most types of cancer, several studies concluded that obesity had an inverse influence on LUAD survival. Increasing evidence showed that obesity-related and adipoc…
View article: Body mass index-associated lncRNAs and their roles in lung cancer
Body mass index-associated lncRNAs and their roles in lung cancer Open
Background: Obesity often increases the risk of cancer and worsens the prognosis. Unlike most types of cancer, obesity and lung cancer displayed a mixed relationship. Several studies concluded that obesity had an inverse impact on incident…
View article: The Association of Human Leukocyte Antigen and COVID-19 in Southern China
The Association of Human Leukocyte Antigen and COVID-19 in Southern China Open
Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and …
View article: Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy
Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy Open
Anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity while reduces lipid deposits. However, the effects of IL-4 on energy metabolism in muscle, the largest insulin-targeting organ, remain obscu…
View article: Distribution of Cytotoxic T Lymphocyte-Associated Antigen-4 Promoter Polymorphisms in Taiwanese Patients with Type 2 Diabetes Mellitus
Distribution of Cytotoxic T Lymphocyte-Associated Antigen-4 Promoter Polymorphisms in Taiwanese Patients with Type 2 Diabetes Mellitus Open
Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation, suggesting the metabolic abnormalities are originated from or exacerbated by cytokine overproduction. Cytokines and counter-regulatory molecules are crucial in keepin…
View article: Interleukin‐4 Boosts Insulin‐Induced Energy Deposits by Enhancing Glucose Uptake and Lipogenesis in Hepatocytes
Interleukin‐4 Boosts Insulin‐Induced Energy Deposits by Enhancing Glucose Uptake and Lipogenesis in Hepatocytes Open
Type 2 diabetes mellitus (T2DM), with dysregulated hepatic gluconeogenesis as the major cause of fasting hyperglycemia, is closely associated with chronic inflammation. We previously demonstrated interleukin‐4 (IL‐4) improves insulin sensi…
View article: Association between resistin promoter -420C&gt;G polymorphisms and producing ability with type 2 diabetes mellitus
Association between resistin promoter -420C>G polymorphisms and producing ability with type 2 diabetes mellitus Open
Elevated resistin levels and the polymorphisms located at gene encoding resistin (RETN) are associated with diabetic pathogenesis. However, the correlation between RETN genotypes and T2DM is controversial due to discrepan…