Kusha Davar
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View article: Practicing With Intent: How to Teach an Old Dogma New Tricks
Practicing With Intent: How to Teach an Old Dogma New Tricks Open
Clinicians are constantly bombarded with an onslaught of newly published data, yet they must make clinical decisions despite a dearth of clinical data. Sometimes, they may fall back on clinical practices entrenched by experience, unaware t…
Interpreting Blood Culture Results as Early Guidance for Infective Endocarditis Open
Importance Few bedside tools with defined accuracy have been described that are useful to alter bayesian prior probability for infective endocarditis (IE) in patients with bacteremia. Objective To evaluate the accuracy of simple blood cult…
View article: Outpatient Oral Doxycycline Therapy for Ocular Syphilis
Outpatient Oral Doxycycline Therapy for Ocular Syphilis Open
This cohort study compares the outcomes of oral doxycycline therapy with those of intravenous penicillin therapy among patients with ocular syphilis.
View article: Virtual Home Care for Patients With Acute Illness
Virtual Home Care for Patients With Acute Illness Open
Importance Recent evolutions in clinical care and remote monitoring suggest that some acute illnesses no longer require intravenous therapy and inpatient hospitalization. Objective To describe outcomes of patients receiving care in a new, …
View article: Progression of Rheumatic Heart Disease
Progression of Rheumatic Heart Disease Open
Recurrent acute rheumatic fever in patients who have completed secondary antibiotic prophylaxis is exceedingly rare. This paper presents a case of recurrent acute rheumatic fever with progressive rheumatic heart disease in a middle-aged wo…
<i>Plasmodium vivax</i> Infections among Immigrants from China Traveling to the United States Open
Beginning in 2023, we observed increased Plasmodium vivax malaria cases at an institution in Los Angeles, California, USA. Most cases were among migrants from China who traveled to the United States through South and Central America. US cl…
Case Report: Cardiovascular Manifestations due to Flea-Borne Typhus Open
Flea-borne typhus is a vector-borne disease caused by Rickettsia typhi that occurs worldwide, except in Antarctica. In the United States, most cases are restricted to California, Hawaii, and Texas. The syndrome is characterized by nonspeci…
View article: Guidelines for Diagnosis and Management of Infective Endocarditis in Adults
Guidelines for Diagnosis and Management of Infective Endocarditis in Adults Open
Importance Practice guidelines often provide recommendations in which the strength of the recommendation is dissociated from the quality of the evidence. Objective To create a clinical guideline for the diagnosis and management of adult ba…
Burying Hatchets into Endemic Diagnoses: Disseminated Blastomycosis from a Potentially Novel Occupational Exposure Open
Background: Blastomycosis is an endemic fungal disease predominantly observed in the northern regions of North America. It manifests primarily as pulmonary disease but can also involve dissemination to the skin, bones, and genitourinary tr…
Burying Hatchets into Endemic Diagnoses: Disseminated Blastomycosis in a Novel Occupational Exposure Open
Blastomycosis is an endemic fungal disease seen prominently in the northern regions of North America, manifested as pulmonary disease, however also with dissemination to the skin, bones, and genitourinary tract. We describe a case of a pat…
Disseminated <i>Bartonella quintana</i> Causing Osseous Lytic Lesions Open
Bartonella, a gram-negative bacterium, causes various clinical syndromes such as cat scratch disease (B henselae), Carrion disease (B bacilliformis), and trench fever (B quintana). Given the pathogenicity, it is imperative to understand th…
Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study Open
Background We sought to compare the outcomes of patients treated with intravenous (IV)-only vs oral transitional antimicrobial therapy for infective endocarditis (IE) after implementing a new expected practice within the Los Angeles County…
Can the Future of ID Escape the Inertial Dogma of Its Past? The Exemplars of Shorter Is Better and Oral Is the New IV Open
Like all fields of medicine, Infectious Diseases is rife with dogma that underpins much clinical practice. In this study, we discuss 2 specific examples of historical practice that have been overturned recently by numerous prospective stud…
Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults Open
The WikiGuidelines approach offers a novel methodology for clinical guideline development that precludes recommendations based on low-quality data or opinion. The primary limitation is the need for more rigorous clinical investigations, en…
View article: A Rare Bird: Diagnosis of Psittacosis Meningitis by Clinical Metagenomic Next-Generation Sequencing
A Rare Bird: Diagnosis of Psittacosis Meningitis by Clinical Metagenomic Next-Generation Sequencing Open
Psittacosis is a zoonotic infectious disease caused by the transmission of Chlamydia psittaci; it often presents as a pulmonary infection but rarely as disseminated disease. Because diagnoses of psittacosis are often underreported due to i…
Case Report and Genomic Analysis of Cefiderocol-Resistant <i>Escherichia coli</i> Clinical Isolates Open
Objectives Cefiderocol is a novel siderophore cephalosporin with in vitro activity against multidrug-resistant (MDR), gram-negative bacteria and intrinsic structural stability to all classes of carbapenemases. We sought to identify gene va…
1135. The PEST Approach to Choosing Antimicrobial Therapy Open
Background Selecting an empiric antimicrobial regimen can be difficult for early learners and misuse of antibiotics can lead to adverse events and antimicrobial resistance. We describe here an approach to aid internal medicine interns in t…
View article: Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans — Los Angeles, California, 2020
Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans — Los Angeles, California, 2020 Open
On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (CO…