Kwangmin Choi
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View article: Elimination of stretcher strain marks in high-Mg Al-Mg alloys: deformation behavior and microstructural insights in H16 temper
Elimination of stretcher strain marks in high-Mg Al-Mg alloys: deformation behavior and microstructural insights in H16 temper Open
View article: Exploring Organ‐Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity
Exploring Organ‐Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity Open
Objective Vertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to…
View article: Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas Open
Loss of NF1 in Schwann cells leads to activation of the RAS-MAPK pathway, followed by immune cell recruitment and development of benign nerve tumors (PNFs). MEK inhibitors, which shrink most PNFs, also reduce tumor-associated myeloid cells…
View article: Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization Open
View article: Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome
Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome Open
View article: MYD88 mutations in clonal hematopoiesis promote inflammation and hematopoietic stem cell expansion
MYD88 mutations in clonal hematopoiesis promote inflammation and hematopoietic stem cell expansion Open
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by expansion of mutant hematopoietic stem and progenitor cells (HSPCs) and an increased risk of chronic diseases and cancers. While mutations in DNMT3A , TET2 , and AS…
View article: Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming
Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming Open
Introduction Immune resilience is the capacity of the immune system to recover from sepsis-induced organ injury and reestablish host defense. While sepsis survivors are often viewed as immunocompromised, recent studies suggest that some ma…
View article: Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation
Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation Open
Plexiform neurofibroma (PNF) is an immune cell-rich peripheral nerve sheath tumor that develops primarily in individuals with Neurofibromatosis Type 1 (NF1). Granulocyte-macrophage colony stimulating factor receptor-β (GM-CSFR-βc) is a sha…
View article: Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Adolescents with Obesity
Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Adolescents with Obesity Open
Aims/hypothesis Vertical sleeve gastrectomy (VSG) leads to significant metabolic improvements, though the underlying molecular mechanisms are not yet fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) con…
View article: Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice
Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice Open
View article: Stimulator of interferon gene facilitates recruitment of effector CD8 T cells that drive neurofibromatosis type 1 nerve tumor initiation and maintenance
Stimulator of interferon gene facilitates recruitment of effector CD8 T cells that drive neurofibromatosis type 1 nerve tumor initiation and maintenance Open
Plexiform neurofibromas (PNFs) are benign nerve tumors driven by loss of the NF1 tumor suppressor in Schwann cells. PNFs are rich in immune cells, but whether immune cells are necessary for tumorigenesis is unknown. We show that inhibition…
View article: Natural and Artificial Aging Effects on the Deformation Behaviors of Al–Mg–Zn Alloy Sheets
Natural and Artificial Aging Effects on the Deformation Behaviors of Al–Mg–Zn Alloy Sheets Open
This study investigated the effects of aging profiles on the precipitate formation and the corresponding strengthening and deformation behaviors of Al–Mg–Zn alloys. The alloys subjected to natural aging (NA) demonstrated significantly enha…
View article: Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 2
View article: Supplementary Figure legend from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Figure legend from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Figure legend
View article: Supplementary Fig 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 3
View article: Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 2
View article: Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
The genetic landscape of cancer cells can lead to specific metabolic dependencies for tumor growth. Dietary interventions represent an attractive strategy to restrict the availability of key nutrients to tumors. In this study, we identifie…
View article: Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 6
View article: Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 6
View article: Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 4
View article: Supplementary Fig 5 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 5 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 5
View article: Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 4
View article: Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 1
View article: Supplementary Table 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 3
View article: Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 2
View article: Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
The genetic landscape of cancer cells can lead to specific metabolic dependencies for tumor growth. Dietary interventions represent an attractive strategy to restrict the availability of key nutrients to tumors. In this study, we identifie…
View article: Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 2
View article: Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 1
View article: Supplementary Table 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 1
View article: Supplementary Figure legend from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Figure legend from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Figure legend