Kwok Wai Lo
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View article: An Operational Flood Risk Assessment System for Better Resilience Against Rain‐Induced Impacts Under Climate Change in Hong Kong
An Operational Flood Risk Assessment System for Better Resilience Against Rain‐Induced Impacts Under Climate Change in Hong Kong Open
Under the background of climate change, extreme weather events are apparently becoming more frequent. In Hong Kong, a record‐breaking ‘Black’ Rainstorm on 7–8 September 2023 brought widespread flooding and caused landslides, paralysing the…
View article: SiniticMTError: A Machine Translation Dataset with Error Annotations for Sinitic Languages
SiniticMTError: A Machine Translation Dataset with Error Annotations for Sinitic Languages Open
Despite major advances in machine translation (MT) in recent years, progress remains limited for many low-resource languages that lack large-scale training data and linguistic resources. Cantonese and Wu Chinese are two Sinitic examples, a…
View article: Multimodal AI-based risk stratification for distant metastasis in nasopharyngeal carcinoma
Multimodal AI-based risk stratification for distant metastasis in nasopharyngeal carcinoma Open
The proposed digital score demonstrates robust predictive performance for distant metastasis, overall survival, and local recurrence in NPC. These findings highlight its potential to assist with personalised treatment strategies and improv…
View article: Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study
Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study Open
Background Lymph node dissection is a standardized procedure in gastric cancer surgery. Typically, lymph node metastasis begins in the perigastric (PG) region and then extends to the extraperigastric (EP) region. However, in some circumsta…
View article: Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines
Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines Open
Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell line…
View article: ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells
ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells Open
Background In EBV-associated epithelial cancers, only a limited number of viral proteins are translated, while multiple EBV-encoded non-coding RNAs are expressed to minimize activation of the host’s immune response. These non-coding RNAs h…
View article: FIGURE 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
NPC268 is characterized by a high number of SVs and showed enrichment in immune-related gene expression. A, Circos plot showing an overview of genomic aberrations in NPC268 as revealed by WGS analysis. From outer to inner rings: (1)…
View article: FIGURE 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Drug sensitivity profile of NPC268 and other NPC cell lines show preferential sensitivity of NPC268 toward BCL2 inhibitors. A, High-throughput screening on 339 drugs was performed on NPC268 and other NPC cell lines (EBV-negative: NP…
View article: FIGURE 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
EBV is preserved in NPC268 and can be induced into lytic infection. A, EBER staining was positive in early and late passage of NPC268, but LMP1 and BZLF1 protein expressions were lost in the late passage. Scale bar: 100 µm. B,
View article: FIGURE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Establishment of a new EBV-positive NPC cell line, NPC268 from a non-keratinizing differentiated NPC primary tumor. A, H&E staining revealed NPC268 tumor as the non-keratinizing, differentiated NPC subtype. Scale bar: 100 µm. B,<…
View article: FIGURE 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
NPC268 is highly tumorigenic and demonstrate lytic activity in vivo. A,In vivo growth curve of NPC268 mouse xenografts (early passage xenograft, E-X-1, E-X-2, E-X-3 and late passage xenograft, L-X-1, L-X-2, L-X-3). …
View article: Supplementary Figure 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
Supplementary Figure 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Karyotype analysis of NPC268 and confirmation of epithelial origin.
View article: Data from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
Data from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Nasopharyngeal carcinoma (NPC), a cancer that is etiologically associated with the Epstein-Barr virus (EBV), is endemic in Southern China and Southeast Asia. The scarcity of representative NPC cell lines owing to the frequent loss of EBV e…
View article: FIGURE 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
NPC268 resembles the HypoNPC subtype and showed enrichment in immune-related gene expression. A, WGBS analysis revealed the methylation level of NPC268, resembling that of HypoNPC subtype. Heat map shows the global methylation level…
View article: FIGURE 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
EBV genome analysis of NPC268 reveals resemblance with those commonly found in NPC from endemic regions. A, PCA of the 213 EBV genomes was performed. PC2 was plotted against PC1, each dot represents a previously published EBV genome…
View article: Characterizing resistant cellular states in nasopharyngeal carcinoma during EBV lytic induction
Characterizing resistant cellular states in nasopharyngeal carcinoma during EBV lytic induction Open
View article: Epstein–Barr Virus Sequence Variations Among the Understudied Nasopharyngeal Carcinoma Patients of Diverse Ancestries in Southeast Asia
Epstein–Barr Virus Sequence Variations Among the Understudied Nasopharyngeal Carcinoma Patients of Diverse Ancestries in Southeast Asia Open
Epstein–Barr virus (EBV) is associated with cancers, including lymphomas and nasopharyngeal carcinoma (NPC). To date, risk variants for NPC were mainly identified from Chinese populations, which dominated the world's total number of cases.…
View article: Development of a broadly potent neutralizing antibody targeting Nidogen 1 effectively inhibits cancer growth and metastasis in preclinical tumor models
Development of a broadly potent neutralizing antibody targeting Nidogen 1 effectively inhibits cancer growth and metastasis in preclinical tumor models Open
Background and Objectives Nidogen 1 (NID1) is a highly conserved structural component of the extracellular matrix (ECM), which interacts with different basement membrane (BM) proteins to form a stabilized meshwork. The promoting ability of…
View article: An Operational Flood Risk Assessment System for Better Resilience Against Rain-Induced Impacts Under Climate Change in Hong Kong
An Operational Flood Risk Assessment System for Better Resilience Against Rain-Induced Impacts Under Climate Change in Hong Kong Open
View article: Deciphering the Differences Between Epstein–Barr Virus‐Associated and Negative Gastric Cancer in the Prospect of <i>CDKN2A</i> Genomic Alterations and Lymphoid Infiltration
Deciphering the Differences Between Epstein–Barr Virus‐Associated and Negative Gastric Cancer in the Prospect of <i>CDKN2A</i> Genomic Alterations and Lymphoid Infiltration Open
Background Gastric cancer (GC) is a major health concern worldwide. One important contributing factor is the presence of the Epstein‐Barr virus (EBV). However, the molecular pattern of how EBV participates in the malignant transition proce…
View article: Figure S13 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S13 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S13
View article: Figure S1 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S1 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S1
View article: Figure S3 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S3 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S3
View article: Data from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Data from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
The Hippo–YAP1 pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration. Dysregulation of Hippo–YAP1 signaling promotes initiation and progression of several types of cancer, including gastri…
View article: Figure S14 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S14 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S14
View article: Figure S10 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S10 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S10
View article: Figure S9 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S9 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S9
View article: Figure S7 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S7 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S7
View article: Figure S11 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S11 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S11
View article: Figure S12 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Figure S12 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis Open
Supplementary Figure S12