Ken K. Y. Ho
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View article: Development of a Minimum Dataset for the Global Monitoring of the Safety and Efficacy of Growth Hormone Replacement in Adults With Growth Hormone Deficiency (AGHD)
Development of a Minimum Dataset for the Global Monitoring of the Safety and Efficacy of Growth Hormone Replacement in Adults With Growth Hormone Deficiency (AGHD) Open
Objective To identify the minimum dataset (MDS) for the monitoring of safety and effectiveness of GH in adults with growth hormone deficiency (AGHD). Design Systematic review and expert consensus. Methods Outcomes for AGHD were identified …
View article: A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update
A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update Open
OBJECTIVE: The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. PARTICIPANTS: The Consensus Group, convened by 11 Steering Committee…
View article: Diagnosis and testing for growth hormone deficiency across the ages: a global view of the accuracy, caveats, and cut-offs for diagnosis
Diagnosis and testing for growth hormone deficiency across the ages: a global view of the accuracy, caveats, and cut-offs for diagnosis Open
Growth hormone deficiency (GHD) is a clinical syndrome that can manifest either as isolated or associated with additional pituitary hormone deficiencies. Although diminished height velocity and short stature are useful and important clinic…
View article: Managing Estrogen Therapy in the Pituitary Patient
Managing Estrogen Therapy in the Pituitary Patient Open
Growth hormone (GH) regulates metabolic and physical health in the adult human. Because the GH system is regulated by estrogens, therapeutic estrogen compounds are likely to affect metabolic health. Estrogens are available for oral and par…
View article: The physiology of growth hormone (GH) in adults: translational journey to GH replacement therapy
The physiology of growth hormone (GH) in adults: translational journey to GH replacement therapy Open
The fact that growth hormone (GH) plays an important role in health after the cessation of growth requiring replacement therapy in adult life has only been recognised in the last three decades. This has only been made possible by recombina…
View article: Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement
Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement Open
Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concer…
View article: Clinical Biology of the Pituitary Adenoma
Clinical Biology of the Pituitary Adenoma Open
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of divers…
View article: Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement
Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement Open
Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concer…
View article: A Novel Liver-targeted Testosterone Therapy for Sarcopenia in Androgen Deprived Men With Prostate Cancer
A Novel Liver-targeted Testosterone Therapy for Sarcopenia in Androgen Deprived Men With Prostate Cancer Open
Objective Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted t…
View article: MECHANISMS IN ENDOCRINOLOGY: Paracrine and endocrine control of the growth hormone axis by estrogen
MECHANISMS IN ENDOCRINOLOGY: Paracrine and endocrine control of the growth hormone axis by estrogen Open
There is a strong biological link between the growth hormone (GH) and gonadal systems in growth, development and metabolism; however, regulatory interactions are poorly understood. Advances in estrogen biology and endocrine physiology have…
View article: Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?
Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? Open
The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society…
View article: GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults
GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults Open
Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that ‘…
View article: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2‐Bl/HLA‐G
Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2‐Bl/HLA‐G Open
Background and Aims Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling…
View article: Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations: Table 1
Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations: Table 1 Open
The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH).
View article: The promise of growth hormone in sport: doped or duped
The promise of growth hormone in sport: doped or duped Open
Skeletal muscle is a target tissue of GH. Based on its anabolic properties, it is widely accepted that GH enhances muscle performance in sports. Athletic performance depends on muscle strength and the energy required to power muscle functi…
View article: A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update
A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update Open
Objective The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. Participants The Consensus Group, convened by 11 Steering Committee m…
View article: The Use and Abuse of Growth Hormone in Sports
The Use and Abuse of Growth Hormone in Sports Open
GH is banned by the World Anti-Doping Agency as a performance-enhancing anabolic agent. Doping with GH likely began in the early 1980s and became more prevalent with the advent of recombinant technology well before any scientific evidence …
View article: Disparate Effect of Aromatization on the Central Regulation of GH Secretion by Estrogens in Men and Postmenopausal Women
Disparate Effect of Aromatization on the Central Regulation of GH Secretion by Estrogens in Men and Postmenopausal Women Open
Because estrogen deprivation reduced circulating GH, we conclude that estrogens regulate GH secretion in men. In postmenopausal women, the neutral effect of aromatase inhibition is likely explained by pre-existing estrogen deficiency. The …
View article: The promise of growth hormone in sport: doped or duped
The promise of growth hormone in sport: doped or duped Open
Skeletal muscle is a target tissue of GH. Based on its anabolic properties, it is widely accepted that GH enhances muscle performance in sports. Athletic performance depends on muscle strength and the energy required to power muscle functi…