Alfred K. Lam
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View article: Metagenomes and metagenome-assembled genomes from tidal lagoons at a New York City waterfront park
Metagenomes and metagenome-assembled genomes from tidal lagoons at a New York City waterfront park Open
New York City parks serve as potential sites of both social and physical climate resilience, but relatively little is known about how microbial organisms and processes contribute to the functioning of these deeply human-impacted ecosystems…
View article: Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism
Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism Open
Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current litera…
View article: Risk of second primary cancers among melanoma survivors following radiotherapy: A population-based cohort study
Risk of second primary cancers among melanoma survivors following radiotherapy: A population-based cohort study Open
Radiotherapy was associated with a modest but statistically significant increase in long-term SPC risk in melanoma survivors, particularly for radiosensitive cancers. These findings support the need for long-term, risk-adapted surveillance…
View article: Systematic Analysis of the Differential Effects of Red Meat on Colorectal Cancer Risks: A Meta-Analytic Approach
Systematic Analysis of the Differential Effects of Red Meat on Colorectal Cancer Risks: A Meta-Analytic Approach Open
Objectives Colorectal cancer (CRC) is the third most common cancer worldwide, with rising incidence in younger populations. Red meat consumption has been proposed as a risk factor for CRC, though the evidence remains inconsistent. This sys…
View article: Assessing the Use of Left Atrial Strain Before and After Treadmill Exercise Stress Echocardiography
Assessing the Use of Left Atrial Strain Before and After Treadmill Exercise Stress Echocardiography Open
Aims Left atrial strain (LAS) is a novel speckle‐tracking technique used in the assessment of left atrial function. It has been shown to be a marker for adverse cardiac events (heart failure, myocardial ischemia, and atrial fibrillation). …
View article: A scoping review and evidence map of radiofrequency field exposure and genotoxicity: assessing in vivo, in vitro, and epidemiological data
A scoping review and evidence map of radiofrequency field exposure and genotoxicity: assessing in vivo, in vitro, and epidemiological data Open
Background Studies investigating genotoxic effects of radiofrequency electromagnetic field (RF-EMF) exposure (3 kHz−300 GHz) have used a wide variety of parameters, and results have been inconsistent. A systematic mapping of existing resea…
View article: NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA
NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA Open
N‐acetyltransferase 10 (NAT10)‐catalyzed N4‐acetylcytidine (ac4C) modification has been reported to drive tumor metastasis. Lysosomal dysregulation plays an important role in human diseases, but its function in esophageal cancer metastasis…
View article: Anatomical and histological characterization of the filum terminale in dogs
Anatomical and histological characterization of the filum terminale in dogs Open
The filum terminale (FT) remains poorly characterized in the veterinary literature, limiting understanding of its role in spinal cord and nerve root pathologies such as tethered cord syndrome. This study aimed to establish baseline anatomi…
View article: 3D Software Synthesis Guided by Constraint-Expressive Intermediate Representation
3D Software Synthesis Guided by Constraint-Expressive Intermediate Representation Open
Graphical user interface (UI) software has undergone a fundamental transformation from traditional two-dimensional (2D) desktop/web/mobile interfaces to spatial three-dimensional (3D) environments. While existing work has made remarkable s…
View article: Mutation profiling of KRAS and BRAF in primary tumours and circulating tumour cells of colorectal cancer patients using PNA-LNA molecular switch
Mutation profiling of KRAS and BRAF in primary tumours and circulating tumour cells of colorectal cancer patients using PNA-LNA molecular switch Open
Identifying KRAS and BRAF mutation status is essential for guiding targeted therapies and enhancing treatment outcomes in colorectal cancer (CRC). This study employs the "PNA-LNA molecular switch" to detect mutations in KRAS codon 12 (c.35…
View article: The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential
The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential Open
Background Despite significant therapeutic advancements in recent decades, colorectal cancer (CRC) continues to exhibit high rates of mortality and morbidity. Chemoresistance and cancer recurrence remain substantial challenges, underscorin…
View article: Novel blood signature for hepatocellular carcinoma screening
Novel blood signature for hepatocellular carcinoma screening Open
Background Alpha-fetoprotein is commonly used for hepatocellular carcinoma (HCC) screening in at-risk populations, but its effectiveness is limited. Routine blood tests offer insights into cancer-related conditions and improve detection in…
View article: LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5 Open
Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC meta…
View article: Mutation profiling of<i>KRAS</i>and<i>BRAF</i>in primary tumors and circulating tumor cells of colorectal cancer patients using PNA-LNA molecular switch
Mutation profiling of<i>KRAS</i>and<i>BRAF</i>in primary tumors and circulating tumor cells of colorectal cancer patients using PNA-LNA molecular switch Open
Identifying KRAS and BRAF mutation status is essential for guiding targeted therapies and enhancing treatment outcomes in colorectal cancer (CRC). This study employs the “PNA-LNA molecular switch” to detect mutations in KRAS codon 12 (c.35…
View article: Therapeutics controversies in antineutrophilic cytoplasmic antibody-associated vasculitis
Therapeutics controversies in antineutrophilic cytoplasmic antibody-associated vasculitis Open
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by inflammation of small- to medium-sized blood vessels with ANCAs. Induction therapy has historically involved cyclophosphamide (CYC) and glucocortic…
View article: Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges
Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges Open
Gaining significant attention in recent years, starvation therapy based on the blocking nutrients supply to cancer cells via blood occlusion and metabolic interventions is a promisingly novel approach in cancer treatment. However, there ar…
View article: Metagenomes and Metagenome-Assembled Genomes from Tidal Lagoons at a New York City Waterfront Park
Metagenomes and Metagenome-Assembled Genomes from Tidal Lagoons at a New York City Waterfront Park Open
We report the sequencing and analysis of 15 shotgun metagenomes, including the reconstruction of 129 high-quality metagenome-assembled genomes, from tidal lagoons and bay water at Bush Terminal Piers Park in Brooklyn, NY sampled from July …
View article: Changes in surgical margins following formalin fixation and the incidence of local recurrence of colorectal cancer
Changes in surgical margins following formalin fixation and the incidence of local recurrence of colorectal cancer Open
Background: The surgical margin is an important prognostic factor in predicting the local recurrence of colorectal cancer. The current guidelines recommend a 5cm margin both proximally and distally for colon cancers and a distal resection …
View article: Making Medical Education Socially Accountable in Australia and Southeast Asia: A Systematic Review
Making Medical Education Socially Accountable in Australia and Southeast Asia: A Systematic Review Open
Social accountability (SA) measures are critical in medical education. A systematic review was conducted following PRISMA-systematic review guidelines, across Australia and Southeast Asia Region (SEAR) countries to identify their purposes,…
View article: Comparison between point-of-care international normalised ratio, COAST, TICCS and truncated FibAT scores to rule in clinically significant hypofibrinogenaemia in the prehospital setting
Comparison between point-of-care international normalised ratio, COAST, TICCS and truncated FibAT scores to rule in clinically significant hypofibrinogenaemia in the prehospital setting Open
Background Hypofibrinogenaemia on ED arrival and in the prehospital setting has been associated with both increased mortality and increased blood transfusions. The timely administration of fibrinogen-rich products on arrival to hospital is…
View article: Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention
Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention Open
Metastasis remains a leading cause of cancer‐related deaths, defined by a complex, multi‐step process in which tumor cells spread and form secondary growths in distant tissues. Despite substantial progress in understanding metastasis, the …
View article: Preadmission medications and recent falls in older inpatients: an observational study
Preadmission medications and recent falls in older inpatients: an observational study Open
Background Falls in older adults might increase due to polypharmacy. Aim This study aimed to explore the association between preadmission medications and history of falls in older inpatients. Method This observational study of inpatients a…
View article: Sex differences in the impact of multimorbidity on long-term mortality for patients with colorectal cancer: a population registry-based cohort study
Sex differences in the impact of multimorbidity on long-term mortality for patients with colorectal cancer: a population registry-based cohort study Open
Background Women have better survival than men patients with colorectal cancer (CRC), but the extent to which this is due to multimorbidity is unclear. Methods A population-based study of 1843 patients diagnosed with CRC in Australia. Data…
View article: RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer
RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer Open
Colorectal cancer (CRC) remains a leading cause of cancer‐related deaths, creating an urgent need for innovative diagnostic solutions. Mechanobiology, a cutting‐edge field that investigates how physical forces influence cell behavior, is n…
View article: Correction: Alaei et al. Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models. Cancers 2023, 15, 3939
Correction: Alaei et al. Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models. Cancers 2023, 15, 3939 Open
Error in Figure and Text [...]
View article: PD130 Health Technology Assessment Of Cervical Cancer Screening In Indonesia
PD130 Health Technology Assessment Of Cervical Cancer Screening In Indonesia Open
Introduction Cervical cancer is the most common gynecological cancer and the second most common cancer among women in Indonesia, and its incidence is projected to increase. In 2018, the mortality rate of cervical cancer was 60 percent, sin…