Kyla Gelev
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View article: Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery
Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery Open
Ability to lose weight during different obesity treatments shows substantial variability between individuals and is likely under genetic control; however, the underlying predictive variants and weight loss genes remain unknown. Here we pro…
View article: Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome, which can lead to cirrhosis and liver cancer. While ther…
View article: Integration of single cell omics with biobank data discovers<i>trans</i>effects of<i>SREBF1</i>abdominal obesity risk variants on adipocyte expression of more than 100 genes
Integration of single cell omics with biobank data discovers<i>trans</i>effects of<i>SREBF1</i>abdominal obesity risk variants on adipocyte expression of more than 100 genes Open
Given the fast-increasing prevalence of obesity and its comorbidities, it would be critical to improve our understanding of the cell-type level differences between the two key human adipose tissue depots, subcutaneous (SAT) and visceral ad…
View article: Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue
Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue Open
Human subcutaneous adipose tissue (SAT) contains a diverse array of cell-types; however, the epigenomic landscape among the SAT cell-types has remained elusive. Our integrative analysis of single-cell resolution DNA methylation and chromat…