Kyle Bond
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View article: Mitochondrial organization in the developing proximal tubule is controlled by LRRK2
Mitochondrial organization in the developing proximal tubule is controlled by LRRK2 Open
The proximal tubule of the nephron resorbs water, amino acids and glucose, and its energy demands are high. Formation of the cellular machinery for energy production is an essential step in proximal tubule epithelial cell (PTC) differentia…
View article: Double‐Stranded <scp>RNA</scp> Induces Retinal Pigment Epithelium Cell Degeneration and Inflammation
Double‐Stranded <span>RNA</span> Induces Retinal Pigment Epithelium Cell Degeneration and Inflammation Open
RIG‐I signaling has been previously implicated as a driver of inflammation to the retinal pigment epithelium (RPE) during age‐related macular degeneration (AMD). Double‐stranded RNA (dsRNA) is known to initiate RIG‐I signaling and lead to …
View article: Protective effect of P2Y receptors antagonism on stress-induced retinal degeneration
Protective effect of P2Y receptors antagonism on stress-induced retinal degeneration Open
The death of retinal pigment epithelial (RPE) cells and photoreceptors (PR) is a hallmark of the progression of several degenerative ocular disorders. The precise molecular driver(s) behind RPE and PR cell death, however, remains unknown. …
View article: Phenotypic high-throughput screening identifies aryl hydrocarbon receptor agonism as common inhibitor of toxin-induced retinal pigment epithelium cell death
Phenotypic high-throughput screening identifies aryl hydrocarbon receptor agonism as common inhibitor of toxin-induced retinal pigment epithelium cell death Open
The retinal pigment epithelium (RPE) is essential to maintain retinal function, and RPE cell death represents a key pathogenic stage in the progression of several blinding ocular diseases, including age-related macular degeneration (AMD). …
View article: Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation
Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation Open
RIG-I signaling has been previously implicated as a driver of inflammation to the retinal pigment epithelium (RPE) during age-related macular degeneration (AMD). Double-stranded RNA (dsRNA) is known to initiate RIG-I signaling and lead to …
View article: Targets for Renal Carcinoma Growth Control Identified by Screening FOXD1 Cell Proliferation Pathways
Targets for Renal Carcinoma Growth Control Identified by Screening FOXD1 Cell Proliferation Pathways Open
Clinical association studies suggest that FOXD1 is a determinant of patient outcome in clear cell renal cell carcinoma (ccRCC), and laboratory investigations have defined a role for this transcription factor in controlling the growth of tu…
View article: The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth
The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth Open
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer and is often caused by mutations in the oxygen-sensing machinery of kidney epithelial cells. Due to its pseudo-hypoxic state, ccRCC recruits extensive vasculature and…
View article: Abstract 1901: Collagen remodeling in clear cell renal cell carcinoma: Influence of composition on growth and metabolism
Abstract 1901: Collagen remodeling in clear cell renal cell carcinoma: Influence of composition on growth and metabolism Open
The extracellular matrix (ECM) plays an important role in maintaining the structure and function of the kidney. During aggressive fibrotic disease of the kidney, such as chronic kidney disease (CKD), the kidney extracellular matrix is rapi…
View article: Poster Presentations from the 2018 Maine Medical Center Research Institute (MMCRI) Summer Student Research Program
Poster Presentations from the 2018 Maine Medical Center Research Institute (MMCRI) Summer Student Research Program Open
The following posters were presented as part of the 2018 MMCRI Summer Student Research Program. This program offers undergraduates and medical students a unique opportunity to conduct research in diverse clinical and biomedical science fie…