Kyle C. Kihn
YOU?
Author Swipe
View article: Structural dynamics of the dengue virus non-structural 5 (NS5) interactions with promoter stem-loop A (SLA)
Structural dynamics of the dengue virus non-structural 5 (NS5) interactions with promoter stem-loop A (SLA) Open
The dengue virus (DENV) NS5 protein, essential for viral RNA synthesis, is an attractive antiviral drug target. DENV NS5 interacts with the stem-loop A (SLA) promoter at the 5'-untranslated region of the viral genome to initiate negative-s…
View article: Zinc and RNA Binding Is Linked to the Conformational Flexibility of ZRANB2: A CCCC-Type Zinc Finger Protein
Zinc and RNA Binding Is Linked to the Conformational Flexibility of ZRANB2: A CCCC-Type Zinc Finger Protein Open
Ran-binding domain-containing protein 2 (ZRANB2) is a zinc finger (ZF) protein that plays a key role in alternative splicing. ZRANB2 is composed of two ZF domains that contain four invariant cysteine residues per domain. ZRANB2 binds RNA t…
View article: Structural Dynamics of the Dengue Virus Non-structural 5 (NS5) Interactions with Promoter Stem Loop A (SLA)
Structural Dynamics of the Dengue Virus Non-structural 5 (NS5) Interactions with Promoter Stem Loop A (SLA) Open
The dengue virus (DENV) NS5 protein plays a central role in dengue viral RNA synthesis which makes it an attractive target for antiviral drug development. DENV NS5 is known to interact with the stem-loop A (SLA) promoter at the 5’-untransl…
View article: Characterization of cross-reactive, non-neutralizing monoclonal antibodies against a pandemic GII.4 norovirus variant
Characterization of cross-reactive, non-neutralizing monoclonal antibodies against a pandemic GII.4 norovirus variant Open
Antibodies are thought to play a major role in protection against human norovirus infection. Mouse humoral responses closely mimic those of humans; thus, mouse models are used to characterize norovirus epitopes on the major viral capsid pr…
View article: VICR: A novel software for unbiased video and image analysis in scientific research
VICR: A novel software for unbiased video and image analysis in scientific research Open
In scientific research, objectivity and unbiased data analysis is crucial for the validity and reproducibility of outcomes. This is particularly important for studies involving video or image categorization. A common approach of decreasing…
View article: VICR: A Novel Software for Unbiased Video and Image Analysis in Scientific Research
VICR: A Novel Software for Unbiased Video and Image Analysis in Scientific Research Open
In scientific research, objectivity and unbiased data analysis is crucial for the validity and reproducibility of outcomes. This is particularly important for studies involving video or image categorization. A common approach of decreasing…
View article: Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling
Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling Open
Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive immune systems. Dysregulated IL-1-family cytokine signaling, however, is involved …
View article: Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3
Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3 Open
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis. The mechanisms that drive PRL-3’s oncogenic functions are not well understood, partly due to a lack of research tools available to study this…
View article: The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control
The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control Open
Many multi-domain proteins including the serpin family of serine protease inhibitors contain non-sequential domains composed of regions that are far apart in sequence. Because proteins are translated vectorially from N-to C-terminus, such …
View article: Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin
Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin Open
The serpin plasminogen activator inhibitor 1 (PAI-1) spontaneously undergoes a massive structural change from a metastable and active conformation, with a solvent-accessible reactive center loop (RCL), to a stable, inactive, or latent conf…
View article: Long range allostery mediates the regulation of plasminogen activator inhibitor-1 by vitronectin
Long range allostery mediates the regulation of plasminogen activator inhibitor-1 by vitronectin Open
The serpin plasminogen activator inhibitor 1 (PAI-1) spontaneously undergoes a massive structural change from a metastable, active conformation, with a solvent accessible reactive center loop (RCL), to a stable, inactive or latent conforma…
View article: Interpreting hydrogen-deuterium exchange experiments with molecular simulations: Tutorials and applications of the HDXer ensemble reweighting software [Article v1.0]
Interpreting hydrogen-deuterium exchange experiments with molecular simulations: Tutorials and applications of the HDXer ensemble reweighting software [Article v1.0] Open
Hydrogen-deuterium exchange (HDX) is a comprehensive yet detailed probe of protein structure and dynamics and, coupled to mass spectrometry, has become a powerful tool for investigating an increasingly large array of systems. Computer simu…
View article: Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor Open
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myri…
View article: Modeling the native ensemble of PhuS using enhanced sampling MD and HDX-ensemble reweighting
Modeling the native ensemble of PhuS using enhanced sampling MD and HDX-ensemble reweighting Open
View article: Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor
Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor Open
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myri…
View article: Simulations data for the HDXer tutorials
Simulations data for the HDXer tutorials Open
Simulations data used for the HDXer tutorials found on GitHub: https://github.com/Lucy-Forrest-Lab/HDXer
View article: Simulations data for the HDXer tutorials
Simulations data for the HDXer tutorials Open
Simulations data used for the HDXer tutorials found on GitHub: https://github.com/Lucy-Forrest-Lab/HDXer
View article: Evaluation of the Physicochemical Properties of the Iron Nanoparticle Drug Products: Brand and Generic Sodium Ferric Gluconate
Evaluation of the Physicochemical Properties of the Iron Nanoparticle Drug Products: Brand and Generic Sodium Ferric Gluconate Open
Complex iron nanoparticle-based drugs are one of the oldest and most frequently administered classes of nanomedicines. In the US, there are seven FDA-approved iron nanoparticle reference drug products, of which one also has an approved gen…
View article: Leveraging Hdx-Ms Solution Data and HDX Modeling to Refine Molecular Dynamics Ensembles and Gain an Atomistic Understanding of Biophysical Phenomena
Leveraging Hdx-Ms Solution Data and HDX Modeling to Refine Molecular Dynamics Ensembles and Gain an Atomistic Understanding of Biophysical Phenomena Open
View article: HDX-MS Guided Ensemble Reweighting Approach Characterizes a Large Conformational Rearrangement in the Cytoplasmic Heme Binding Protein PhuS
HDX-MS Guided Ensemble Reweighting Approach Characterizes a Large Conformational Rearrangement in the Cytoplasmic Heme Binding Protein PhuS Open
View article: Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation
Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation Open
View article: Development and characterization of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3)
Development and characterization of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) Open
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis in various solid tumors and leukemias. The mechanisms that drive PRL-3’s oncogenic functions are not well understood, in part due to a lack of…
View article: Comparative Physicochemical Characterization between Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection
Comparative Physicochemical Characterization between Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection Open