Kyle Clagg
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View article: CCDC 2011815: Experimental Crystal Structure Determination
CCDC 2011815: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2011814: Experimental Crystal Structure Determination
CCDC 2011814: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1961483: Experimental Crystal Structure Determination
CCDC 1961483: Experimental Crystal Structure Determination Open
View article: CCDC 1961484: Experimental Crystal Structure Determination
CCDC 1961484: Experimental Crystal Structure Determination Open
View article: CCDC 1961486: Experimental Crystal Structure Determination
CCDC 1961486: Experimental Crystal Structure Determination Open
View article: CCDC 1961485: Experimental Crystal Structure Determination
CCDC 1961485: Experimental Crystal Structure Determination Open
View article: A Benzyne Insertion Approach to Hetisine-Type Diterpenoid Alkaloids: Synthesis of Cossonidine (Davisine)
A Benzyne Insertion Approach to Hetisine-Type Diterpenoid Alkaloids: Synthesis of Cossonidine (Davisine) Open
The hetisine-type natural products exhibit one of the most complex carbon skeletons within the diterpenoid alkaloid family. The use of network analysis has enabled a synthesis strategy to access alkaloids in this class with hydroxylation o…
View article: GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Open
Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderate…
View article: CCDC 1053998: Experimental Crystal Structure Determination
CCDC 1053998: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …