Kyle Cole
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View article: Isolation and Whole-Genome Sequencing of Four Antibiotic-Producing Pseudomonas Strains
Isolation and Whole-Genome Sequencing of Four Antibiotic-Producing Pseudomonas Strains Open
Here, we report the isolation, whole-genome sequencing, and annotation of four novel Pseudomonas isolates. We also evaluate the biosynthetic potential of each genome.
View article: Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα Open
The small molecule gibberellin JRA-003 was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain-enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and significantly inhibits the nuclear translocation o…
View article: Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKalpha
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKalpha Open
The small molecule gibberellin JRA-003 (1) was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and significantly inhibits the nuclear translocati…
View article: Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKalpha
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKalpha Open
The small molecule gibberellin JRA-003 (1) was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and significantly inhibits the nuclear translocati…
View article: Triazine Probes Target Ascorbate Peroxidases in Plants
Triazine Probes Target Ascorbate Peroxidases in Plants Open
Though they are rare in nature, anthropogenic 1,3,5-triazines have been used in herbicides as chemically stable scaffolds. Here, we show that small 1,3,5-triazines selectively target ascorbate peroxidases (APXs) in Arabidopsis (Arabidopsis…
View article: Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor
Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor Open
Protein disulfide isomerase A1 (PDIA1) is an endoplasmic reticulum (ER)-localized thiol-disulfide oxidoreductase that is an important folding catalyst for secretory pathway proteins. PDIA1 contains two active-site domains (a and a'), each …
View article: Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor Open
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing in…