Kyle D. Flack
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View article: Exploring Strategies to Promote Exercise as a Viable Obesity and Chronic Disease Treatment
Exploring Strategies to Promote Exercise as a Viable Obesity and Chronic Disease Treatment Open
Obesity and its related comorbidities continue to be a primary public health concern, especially in the United States (US). Such comorbidities include the top two causes of death in the US: cardiovascular disease and cancer. Obesity is als…
View article: The Role of Dietary Protein in Body Weight Regulation among Active-Duty Military Personnel during Energy Deficit: A Systematic Review
The Role of Dietary Protein in Body Weight Regulation among Active-Duty Military Personnel during Energy Deficit: A Systematic Review Open
Active-duty military personnel are subjected to sustained periods of energy deficit during combat and training, leaving them susceptible to detrimental reductions in body weight. The importance of adequate dietary protein intake during per…
View article: Altered motivation states for physical activity and ‘appetite’ for movement as compensatory mechanisms limiting the efficacy of exercise training for weight loss
Altered motivation states for physical activity and ‘appetite’ for movement as compensatory mechanisms limiting the efficacy of exercise training for weight loss Open
Weight loss is a major motive for engaging in exercise, despite substantial evidence that exercise training results in compensatory responses that inhibit significant weight loss. According to the Laws of Thermodynamics and the CICO (Calor…
View article: Dietary Temperature’s Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design
Dietary Temperature’s Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design Open
Background According to the first law of thermodynamics, energy cannot be created or destroyed in an isolated system. Water has a characteristically high heat capacity, indicating that the temperature of ingested fluids and meals could con…
View article: Late-stage Attentional Bias towards Food Cues Varies According to Weight Status
Late-stage Attentional Bias towards Food Cues Varies According to Weight Status Open
The Current food environment has become increasingly obesogenic, with rates of obesity and related conditions continually rising. Advertisements for energy-dense foods are abundant and promote unhealthy eating behaviors by capitalizing on …
View article: Dietary Temperature’s Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design (Preprint)
Dietary Temperature’s Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design (Preprint) Open
BACKGROUND According to the first law of thermodynamics, energy cannot be created or destroyed in an isolated system. Water has a characteristically high heat capacity, indicating that the temperature of ingested fluids and meals could co…
View article: Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial
Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial Open
Background Current therapies for obesity treatment are effective at producing short-term weight loss, but weight loss maintenance remains a significant challenge. Here we investigate the impact of pre-intervention dietary fat intake on the…
View article: Food-Related Stimuli Impair Inhibitory Control in Adults Classified As Overweight to Obese
Food-Related Stimuli Impair Inhibitory Control in Adults Classified As Overweight to Obese Open
OBJECTIVES: The present study investigated the influence of food-related cues on motor impulsivity in sedentary adults classified as overweight to obese (BMI 25–45) using a food-specific Go/NoGo Task. Response inhibition was measured by pr…
View article: Inhibitory control datasets
Inhibitory control datasets Open
SPSS files containing all data used in manuscript
View article: Energy Compensation with Exercise and Dietary-Induced Weight Loss
Energy Compensation with Exercise and Dietary-Induced Weight Loss Open
Obesity-related conditions are among the most expensive health care problems, accounting for $92 billion to $117 billion in annual health care costs. Obesity treatment has therefore emerged as a prime focus of health care. However, there i…
View article: Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity
Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity Open
Prior work suggests that actual, but not estimated, energy density drives the reinforcing value of food and that energy from fat and carbohydrate can interact to potentiate reward. Here we sought to replicate these findings in an American …
View article: Fat and carbohydrate interact to potentiate food reward in healthy weight but not in overweight or obesity
Fat and carbohydrate interact to potentiate food reward in healthy weight but not in overweight or obesity Open
Prior work suggests that actual, but not estimated, energy density drives the reinforcing value of food [1,2] and that energy from fat and carbohydrate can interact to potentiate reward [2]. Here we sought to replicate these findings in an…
View article: The consequences of exercise-induced weight loss on food reinforcement. A randomized controlled trial
The consequences of exercise-induced weight loss on food reinforcement. A randomized controlled trial Open
In support of previous work, reductions in fat-free mass resulting from an aerobic exercise intervention aimed at weight loss plays an important role in energy balance regulation by increasing operant responding for food.
View article: High Intensity Interval Training to Increase Tolerance for Exercise Intensity
High Intensity Interval Training to Increase Tolerance for Exercise Intensity Open
View article: Exercise for Weight Loss: Further Evaluating Energy Compensation with Exercise
Exercise for Weight Loss: Further Evaluating Energy Compensation with Exercise Open
Purpose This study assessed how individuals compensate for energy expended during a 12-wk aerobic exercise intervention, elucidating potential mechanisms and the role exercise dose plays in the compensatory response. Participants and Desig…
View article: Active Videogames to Promote Traditional Active Play: Increasing the Reinforcing Value of Active Play Among Low-Active Children
Active Videogames to Promote Traditional Active Play: Increasing the Reinforcing Value of Active Play Among Low-Active Children Open
Background: Exercise reinforcement predicts physical activity of children. Repeated exposures of physical activity may increase physical activity reinforcement (incentive sensitization). Active videogame (AVG) play produces l…
View article: Increasing the Reinforcing Value of Exercise in Overweight Adults
Increasing the Reinforcing Value of Exercise in Overweight Adults Open
Objectives: This study determined whether a moderate- or high-dose exercise program increases exercise reinforcement. Increasing the relative reinforcing value of exercise (RRVexercise; i.e., incentive sensitization of ex…
View article: Genetic Variations in the Dopaminergic Reward System Are Associated with Exercise Reinforcement (P16-013-19)
Genetic Variations in the Dopaminergic Reward System Are Associated with Exercise Reinforcement (P16-013-19) Open
View article: Reconsidering the Energy Homeostasis Hypothesis. the Proposed Role of Fat-Free Mass (FFM) and Resting Metabolic Rate (RMR) Driving Increased Energy Intake After Weight Loss (OR09-04-19)
Reconsidering the Energy Homeostasis Hypothesis. the Proposed Role of Fat-Free Mass (FFM) and Resting Metabolic Rate (RMR) Driving Increased Energy Intake After Weight Loss (OR09-04-19) Open
OBJECTIVES: Hypotheses of appetite control and food reinforcement are based on gut and adipose peptide signaling to central appetite centers. Contemporary models propose that RMR and FFM changes modify food reinforcement and this may be be…
View article: Energy compensation in response to aerobic exercise training in overweight adults
Energy compensation in response to aerobic exercise training in overweight adults Open
Weight loss from exercise is often less than expected. Putative compensatory mechanisms may limit exercise-induced reductions in body fat and might be proportional to exercise energy expenditure (ExEE). This study was conducted to determin…
View article: The Utility of Exercise for Weight Control
The Utility of Exercise for Weight Control Open
In August of 2009, TIME magazine created a minor uproar among exercise professionals with their cover story The Myth About Exercise stating that it "… won't make you lose weight".Many of us were quick to point out that if exercise was inde…
View article: Aerobic and resistance exercise reinforcement and discomfort tolerance predict meeting activity guidelines
Aerobic and resistance exercise reinforcement and discomfort tolerance predict meeting activity guidelines Open
Having greater RRV of a mode of exercise is associated with meeting activity guidelines for that mode of exercise. Discomfort tolerance during exercise is associated with greater RRV of resistance exercise.
View article: Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults
Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults Open
Whether resistance exercise training (RET) improves skeletal muscle substrate oxidative capacity and reduces mitochondrial production of reactive oxygen species in older adults remains unclear. To address this, 19 older males (≥60 years) w…
View article: Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training
Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training Open
ClinicalTrials.gov: NCT01112709.