Kyle D. Pedro
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View article: 348 TIL engineered with membrane-bound IL15 (cytoTIL15™) are enriched for tumor-associated antigen reactivity and demonstrate pharmacologically tunable expansion and persistence in the presence of TAA
348 TIL engineered with membrane-bound IL15 (cytoTIL15™) are enriched for tumor-associated antigen reactivity and demonstrate pharmacologically tunable expansion and persistence in the presence of TAA Open
Background We have previously demonstrated the successful generation of membrane-bound IL15 (mbIL15) engineered TIL (cytoTIL15™ therapy) from solid tumors, and acetazolamide (ACZ)-driven regulated expression of mbIL15 resulted in TIL persi…
View article: Supplementary Figure 4 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 4 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 12536K, MyoD expression is higher in the tumor periphery compared to the inner core.
View article: Supplementary Methods and Figure Legend from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Methods and Figure Legend from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 112K, Supplementary Figure legends, primer sequences and Western blot antibody details.
View article: Supplementary Figure 4 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 4 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 12536K, MyoD expression is higher in the tumor periphery compared to the inner core.
View article: Supplementary Methods and Figure Legend from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Methods and Figure Legend from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 112K, Supplementary Figure legends, primer sequences and Western blot antibody details.
View article: Supplementary Figure 5 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 5 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 4148K, Loss of MyoD does not influence its canonical targets in the myogenic differentiation program.
View article: Supplementary Figure 3 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 3 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 1235K, MyoD is expressed in proliferating tumor cells in SmoA1, SmoA2 and Ptch conditional knock out medulloblastoma mouse models.
View article: Data from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Data from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
While medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD as a pu…
View article: Data from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Data from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
While medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD as a pu…
View article: Supplementary Figure 6 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 6 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 2418K, MYOD is expressed across different molecular subgroups of medulloblastoma.
View article: Supplementary Figure 2 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 2 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 14123K, Mouse medulloblastomas with one allele of MyoD trend towards higher Ki67 index with reduction in total number of MyoD+ cells as well as cellular expression.
View article: Supplementary Figure 5 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 5 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 4148K, Loss of MyoD does not influence its canonical targets in the myogenic differentiation program.
View article: Supplementary Figure 1 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 1 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 25456K, Comparative analysis of MyoD +/+; SmoA2, MyoD +/-; SmoA2 and MyoD-/-; SmoA2 mice.
View article: Supplementary Figure 2 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 2 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 14123K, Mouse medulloblastomas with one allele of MyoD trend towards higher Ki67 index with reduction in total number of MyoD+ cells as well as cellular expression.
View article: Supplementary Figure 1 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 1 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 25456K, Comparative analysis of MyoD +/+; SmoA2, MyoD +/-; SmoA2 and MyoD-/-; SmoA2 mice.
View article: Supplementary Figure 3 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 3 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 1235K, MyoD is expressed in proliferating tumor cells in SmoA1, SmoA2 and Ptch conditional knock out medulloblastoma mouse models.
View article: Supplementary Figure 6 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Supplementary Figure 6 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma Open
PDF file - 2418K, MYOD is expressed across different molecular subgroups of medulloblastoma.
View article: 390 Digital spatial profiling and antigen-dependent phenotypic analysis of IL15-engineered tumor-infiltrating lymphocytes (cytoTIL15® therapy) in an allogeneic melanoma PDX model
390 Digital spatial profiling and antigen-dependent phenotypic analysis of IL15-engineered tumor-infiltrating lymphocytes (cytoTIL15® therapy) in an allogeneic melanoma PDX model Open
Background CytoTIL15® therapy is an IL2-independent, engineered TIL product which allows pharmacological control of membrane-bound IL15 (mbIL15). We have previously shown that cytoTIL15® TILs demonstrate enhanced persistence and anti-tumor…
View article: 166 Genetically engineered tumor-infiltrating lymphocytes (cytoTIL15) exhibit IL-2-independent persistence and anti-tumor efficacy against melanoma in vivo
166 Genetically engineered tumor-infiltrating lymphocytes (cytoTIL15) exhibit IL-2-independent persistence and anti-tumor efficacy against melanoma in vivo Open
Background Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) has demonstrated tremendous promise in clinical trials for patients with solid or metastatic tumors.1 However, current TIL therapy requires systemic administration…
View article: A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2
A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2 Open
Significance Understanding mechanisms that control HIV expression will provide insight into HIV replication, latency, and pathogenesis. In particular, HIV latency, which is a major barrier to a cure, is maintained by combinatorial mechanis…
View article: PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS
PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS Open
PCM-16. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS Sebastian Brabetz1, Susanne N. Groebner1, Huriye Seker-Cin1, Norman L. Mack1, Volker Hovestadt1, David T. W. Jones1, Florian Selt1,…