Kyle Dack
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View article: Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective
Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective Open
Several genome wide association studies (GWASs) of orofacial cleft have been conducted. However only a few such studies to date have combined all cleft cases, focused on subtypes other than non-syndromic cleft lip with/without cleft palate…
View article: Genetic Heterogeneity and Homogeneity Among Orofacial Cleft Subtypes: Genome-Wide Association Studies in the Cleft Collective
Genetic Heterogeneity and Homogeneity Among Orofacial Cleft Subtypes: Genome-Wide Association Studies in the Cleft Collective Open
Several genome wide association studies (GWASs) of orofacial cleft have been conducted, however the majority of studies to date have restricted their analysis to non-syndromic cleft lip with/without cleft palate and have not analysed all o…
View article: Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study
Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study Open
Background Maternal vitamin-D and omega-3 fatty acid (DHA) deficiencies during pregnancy have previously been associated with offspring neurodevelopmental traits. However, observational study designs cannot distinguish causal effects from …
View article: COVID-19 cluster surveillance using exposure data collected from routine contact tracing: The genomic validation of a novel informatics-based approach to outbreak detection in England
COVID-19 cluster surveillance using exposure data collected from routine contact tracing: The genomic validation of a novel informatics-based approach to outbreak detection in England Open
Contact tracing was used globally to prevent onwards transmission of COVID-19. Tracing contacts alone is unlikely to be sufficient in controlling community transmission, due to the pre-symptomatic, overdispersed and airborne nature of COVI…
View article: Environmental and genetic predictors of whole blood mercury and selenium concentrations in pregnant women in a UK birth cohort
Environmental and genetic predictors of whole blood mercury and selenium concentrations in pregnant women in a UK birth cohort Open
There is evidence that tissue concentrations of mercury (Hg) and selenium (Se) are predicted by numerous dietary, sociodemographic, environmental, and genetic factors. This study aimed to estimate the relative importance of predictors of H…
View article: Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children
Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children Open
Mercury has high industrial utility and is present in many products, and environmental contamination and occupational exposure are widespread. There are numerous biological systems involved in the absorption, metabolism, and excretion of H…
View article: COVID-19 associated with universities in England, October 2020–February 2022
COVID-19 associated with universities in England, October 2020–February 2022 Open
COVID-19 case numbers among students in England varied considerably. At no time were the observed case numbers as high as expected from community prevalence. Characteristics of universities associated with higher case rates can inform futu…
View article: Genome-wide association study of blood mercury in European pregnant women and children
Genome-wide association study of blood mercury in European pregnant women and children Open
Background Mercury (Hg) is a toxic heavy metal which humans are most commonly exposed to through food chain contamination, especially via fish consumption. Even low-level exposure can be harmful because of the poor clearance rate, particul…
View article: Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort
Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort Open
Mercury is highly toxic metal found in trace quantities in common foods. There is concern that exposure during pregnancy could impair infant development. Epidemiological evidence is mixed, but few studies have examined postnatal growth. Di…
View article: Effect of Returning University Students on COVID-19 Infections in England, 2020
Effect of Returning University Students on COVID-19 Infections in England, 2020 Open
Each September in England, ≈1 million students relocate to study at universities. To determine COVID-19 cases and outbreaks among university students after their return to university during the COVID pandemic in September 2020, we identifi…
View article: Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review
Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review Open
Neurodevelopmental delays can interfere with children’s engagement with the world and further development, and may have negative consequences into adulthood. Mercury is highly toxic and may negatively influence neurodevelopment because it …
View article: Was the risk of death among the population of teachers and other school workers in England and Wales due to COVID-19 and all causes higher than other occupations during the pandemic in 2020? An ecological study using routinely collected data on deaths from the Office for National Statistics
Was the risk of death among the population of teachers and other school workers in England and Wales due to COVID-19 and all causes higher than other occupations during the pandemic in 2020? An ecological study using routinely collected data on deaths from the Office for National Statistics Open
Objectives To estimate occupation risk from COVID-19 among teachers and others working in schools using publicly available data on mortality in England and Wales. Design Analysis of national death registration data from the Office for Nati…
View article: Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis
Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis Open
Objectives A systematic review and meta-analysis to determine the association between active maternal smoking and cleft lip and palate etiology. Data sources Medline, Embase, Web of Science and the Cochrane Library from inception to Novemb…
View article: Mercury and Prenatal Growth: A Systematic Review
Mercury and Prenatal Growth: A Systematic Review Open
The intrauterine environment is critical for healthy prenatal growth and affects neonatal survival and later health. Mercury is a toxic metal which can freely cross the placenta and disrupt a wide range of cellular processes. Many observat…
View article: Maternal cigarette smoking and cleft lip and palate: A systematic review and meta-analysis
Maternal cigarette smoking and cleft lip and palate: A systematic review and meta-analysis Open
Objectives A systematic review and meta-analysis to determine the association between active maternal smoking and cleft lip and palate etiology. Data Sources Medline, Embase, Web of Science and the Cochrane database from inception to Novem…
View article: Statistical training on UK undergraduate psychology courses
Statistical training on UK undergraduate psychology courses Open
An exploratory analysis of the statistical content taught on undergraduate psychology courses in the UK.
View article: Contribution of the BioFire® FilmArray® Meningitis/Encephalitis Panel:
Contribution of the BioFire® FilmArray® Meningitis/Encephalitis Panel: Open
Introduction. Traditional evaluation of meningitis includes cerebrospinalfluid (CSF) culture and gram stain to pinpoint specific causalorganisms. The BioFire® FilmArray® Meningitis/Encephalitis (ME)Panel has been implemented as a more time…