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View article: Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination of INK128 and palbociclib showed strong synergism in HNSCC cells in vitro
View article: Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
List of dropout sgRNAs, non-targeting control sgRNAs, selected sensitizing genes, and KEGG pathway analysis of sensitizing genes
View article: Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Configuration of PinAPL-Py software
View article: Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
CRISPR screening identified cell cycle pathway as synthetic lethal pathway for mTORi in HNSCC
View article: Supplementary Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination therapy with INK128 and palbociclib is effective against HNSCC xenograft
View article: Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted by INK128
View article: Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted by INK128
View article: Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Configuration of PinAPL-Py software
View article: Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
CRISPR screening identified cell cycle pathway as synthetic lethal pathway for mTORi in HNSCC
View article: Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
List of dropout sgRNAs, non-targeting control sgRNAs, selected sensitizing genes, and KEGG pathway analysis of sensitizing genes
View article: Supplementary Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination therapy with INK128 and palbociclib is effective against HNSCC xenograft
View article: Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination of INK128 and palbociclib showed strong synergism in HNSCC cells in vitro
View article: Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination of INK128 and palbociclib showed strong synergism in HNSCC cells in vitro
View article: Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
List of dropout sgRNAs, non-targeting control sgRNAs, selected sensitizing genes, and KEGG pathway analysis of sensitizing genes
View article: Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Configuration of PinAPL-Py software
View article: Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Figure 2 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination of INK128 and palbociclib showed strong synergism in HNSCC cells in vitro. A, Cell viability of Cal27 and HN12 treated with siRNAs for 24 hours, followed by INK128 (30 nmol/L) treatment for another 48 hours, was measured (mean …
View article: Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
CRISPR screening identified the cell-cycle pathway as the synthetic lethal pathway for mTORis in HNSCC. A, Scheme for CRISPR screening. Cal27-Cas9 cells were infected with the human kinome CRIPSR-knockout library, targeting 763 genes consi…
View article: Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted by INK128
View article: Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination therapy with INK128 and palbociclib is effective against HNSCC xenografts. A, Tumor growth curve for HN12 xenografts treated with INK128, palbociclib, and combination (mean ± SEM, n = 10). B, Hematoxylin and eosin staining of H…
View article: Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted by INK128
View article: Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
CRISPR screening identified the cell-cycle pathway as the synthetic lethal pathway for mTORis in HNSCC. A, Scheme for CRISPR screening. Cal27-Cas9 cells were infected with the human kinome CRIPSR-knockout library, targeting 763 genes consi…
View article: Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
CRISPR screening identified cell cycle pathway as synthetic lethal pathway for mTORi in HNSCC
View article: Supplementary Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination therapy with INK128 and palbociclib is effective against HNSCC xenograft
View article: Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
CRISPR screening identified cell cycle pathway as synthetic lethal pathway for mTORi in HNSCC
View article: Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Figure 3 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted by INK128. A, Relative mRNA levels of CCND1 and CCNE1 in Cal27 treated with INK128 and/or palbociclib for 24 hours. B, Signaling change with INK1…
View article: Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Figure 4 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Combination therapy with INK128 and palbociclib is effective against HNSCC xenografts. A, Tumor growth curve for HN12 xenografts treated with INK128, palbociclib, and combination (mean ± SEM, n = 10). B, Hematoxylin and eosin staining of H…
View article: Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Table 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
Configuration of PinAPL-Py software
View article: Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
Supplementary Tables 2 -5 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC Open
List of dropout sgRNAs, non-targeting control sgRNAs, selected sensitizing genes, and KEGG pathway analysis of sensitizing genes