Explanipedia

Myeloid-derived suppressor cells generated from human induced pluripotent stem cells suppress T-cell proliferation 9306 Open

Juan Lama, Wenhan Yu, Rajneesh Jha, Kyle J. Bednar, Dmitry I. Gabrilovich , et al. · 2025

Description Myeloid-derived suppressor cells (MDSCs) are myeloid cells with potent suppressive function. MDSC are generally associated with pathologies, and are otherwise rare, thereby restricting efforts to explore their biology. To addre…

GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral Nociception Open

Luke W Paine, Rohit Gupta, James P. Higham, Javier Aguilera‐Lizarraga, Anne Ritoux , et al. · 2025

These findings identify GPR68 as a key mediator of acid-induced colonic nociception and highlight its potential as a therapeutic target for the treatment of pain in colitis.

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis Open

Fan Yang, Alexis A. Yanes, Miao Li, Patrick J. Heizer, Ivan Linatoc , et al. · 2025

Introduction The human FOXP3 + regulatory T (Treg) cells, a subset of CD4 + T cells with immunosuppressive function, are essential for the maintenance of immune homeostasis and tolerance. Treg cells are a heterogeneous population, subdivid…

Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications Open

Bat‐Erdene Jugder, Eunchong Park, Lijuan Du, Chetan V. Jawale, N.P. Popov , et al. · 2025

Regulatory T cells (Tregs) are central to immune homeostasis and controlling inflammation through multiple mechanisms, however, recent discoveries and advances in technology reveal that Tregs exert a diverse array of functions beyond mere …

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception Open

Luke W Paine, Rohit Gupta, James P. Higham, Javier Aguilera‐Lizarraga, Anne Ritoux , et al. · 2025

Background & Aims Localised acidification from immune cell infiltration and heightened glycolysis contributes to colitis pathology by activating acid-sensing receptors such as GPR68, a proton-sensing GPCR expressed on immune and stromal ce…

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model Open

Kyle J. Bednar, Elena Shanina, Romain Ballet, Edward P Connors, Shiteng Duan , et al. · 2024

CD22, a sialic acid-binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas has made…

Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models Open

Erik P. Karmele, Ana Laura Moldoveanu, Irem Kaymak, Bat‐Erdene Jugder, Rebecca L. Ursin , et al. · 2023

Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn’s Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract. The use of pre-clinical animal models has been in…

Tregs in Autoimmunity: Insights Into Intrinsic Brake Mechanism Driving Pathogenesis and Immune Homeostasis Open

Kyle J. Bednar, Jee Ho Lee, Tatiana Ort · 2022

CD4 + CD25 high Foxp3 + regulatory T-cells (Tregs) are functionally characterized for their ability to suppress the activation of multiple immune cell types and are indispensable for maintaining immune homeostasis and tolerance. Disruption…

Endosomal sequestration of TLR4 antibody induces myeloid-derived suppressor cells and reverses acute Type 1 Diabetes Open

Ada Admin, Kathryn C. S. Locker, Kritika Kachapati, Yuehong Wu, Kyle J. Bednar , et al. · 2022

We previously showed that treating NOD mice with an agonistic monoclonal anti-TLR4/MD2 antibody (TLR4-Ab) reversed acute type one diabetes (T1D). Here, we show that TLR4-Ab reverses T1D by induction of myeloid derived suppressor cells (MDS…

Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes Open

Kathryn C. S. Locker, Kritika Kachapati, Yuehong Wu, Kyle J. Bednar, David Adams , et al. · 2022

We previously showed that treating NOD mice with an agonistic monoclonal anti-TLR4/MD2 antibody (TLR4-Ab) reversed acute type 1 diabetes (T1D). Here, we show that TLR4-Ab reverses T1D by induction of myeloid-derived suppressor cells (MDSCs…

Endosomal sequestration of TLR4 antibody induces myeloid-derived suppressor cells and reverses acute Type 1 Diabetes Open

Ada Admin, Kathryn C. S. Locker, Kritika Kachapati, Yuehong Wu, Kyle J. Bednar , et al. · 2022

We previously showed that treating NOD mice with an agonistic monoclonal anti-TLR4/MD2 antibody (TLR4-Ab) reversed acute type one diabetes (T1D). Here, we show that TLR4-Ab reverses T1D by induction of myeloid derived suppressor cells (MDS…

Enoxacin Up‐Regulates MicroRNA Biogenesis and Down‐Regulates Cytotoxic CD8 T‐Cell Function in Autoimmune Cholangitis Open

Arata Itoh, David Adams, Wenting Huang, Yuehong Wu, Kritika Kachapati , et al. · 2021

Background and Aims Primary biliary cholangitis (PBC) is a prototypical organ‐specific autoimmune disease that is mediated by autoreactive T‐cell attack and destruction of cholangiocytes. Despite the clear role of autoimmunity in PBC, immu…

Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy Open

Arata Itoh, Lorenzo Burgos Ortiz, Kritika Kachapati, Yuehong Wu, David H. Adams , et al. · 2019

We show here that soluble CD137 (sCD137), the alternately spliced gene product of Tnfsfr9, effectively treats acute type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. sCD137 significantly delayed development of end-stage disease…

Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis Open

Kyle J. Bednar, Corwin M. Nycholat, Tadimeti S. Rao, James C. Paulson, Wai‐Ping Fung‐Leung , et al. · 2019

Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects the synovial joints and can lead to bone erosion and cartilage damage. One hallmark of RA is anticitrullinated protein autoantibodies (ACPA) and memory citrulline-sp…

Antigenic Liposomes for Generation of Disease-specific Antibodies Open

Kyle J. Bednar, LaKeya C. Hardy, Johanna M. Smeekens, Dharmendra Raghuwanshi, Shiteng Duan , et al. · 2018

Antibody responses provide critical protective immunity to a wide array of pathogens. There remains a high interest in generating robust antibodies for vaccination as well as understand how pathogenic antibody responses develop in allergie…

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model Open

Kyle J. Bednar, Elena Shanina, Romain Ballet, Edward P Connors, Shiteng Duan , et al. · 2017

CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas has made…

CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice Open

Matthew H. Forsberg, Ashley E. Ciecko, Kyle J. Bednar, Arata Itoh, Kritika Kachapati , et al. · 2017

We previously reported that CD137 (encoded by Tnfrsf9) deficiency suppressed type 1 diabetes (T1D) progression in NOD mice. We also demonstrated that soluble CD137 produced by regulatory T cells contributed to their autoimmune-suppressive …

Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody Open

Kyle J. Bednar, Hiroki Tsukamoto, Kritika Kachapati, Shoichiro Ohta, Yuehong Wu , et al. · 2015

Type 1 diabetes (T1D) is currently an incurable disease, characterized by a silent prodromal phase followed by an acute clinical phase, reflecting progressive autoimmune destruction of insulin-producing pancreatic β-cells. Autoreactive T c…

Therapeutic Approaches to the Treatment of Type 1 Diabetes Open

Kyle J. Bednar · 2015

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