Kyle J. Gerber
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View article: Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3 Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets
The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2 Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons Open
The human genome contains vast genetic diversity in the form of naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein tha…
View article: Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [29, 419, 418], leading …
View article: Correction: 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gαi-AlF4− signaling complex and RGS14 nuclear localization.
Correction: 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gαi-AlF4− signaling complex and RGS14 nuclear localization. Open
VOLUME 293 (2018) PAGES 14616–14631 During production, the labeling of Figs. 1, 3B, and 5B became corrupted. These errors have now been corrected and do not affect the results or conclusions of this work.Figure 3B.View Large Image Figure V…
View article: Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calmodulin (CaM) Effector in Mouse Brain
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calmodulin (CaM) Effector in Mouse Brain Open
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein with an unusual domain structure that allows it to integrate G protein and mitogen-activated protein kinase (MAPK) signaling pathways. RGS14 mRNA and protein are …
View article: Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure
Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure Open
In humans and rodents, stress promotes habit-based behaviors that can interfere with action-outcome decision-making. Further, developmental stressor exposure confers long-term habit biases across rodent-primate species. Despite these homol…
View article: Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity Open