Kang Yu
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View article: TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury
TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury Open
Ferroptosis constitutes a pivotal pathological event following spinal cord injury and presents substantial challenges to the restoration of neurological function. Cystine-glutamate transporter SLC7A11 is essential for maintaining cellular …
View article: <scp>TREM2</scp> Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization‐Mediated Autophagy
<span>TREM2</span> Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization‐Mediated Autophagy Open
Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that TREM2 is highly expressed in microglia and is related to the…
View article: Research on technological innovation decision-making considering government subsidies and corporate reputation
Research on technological innovation decision-making considering government subsidies and corporate reputation Open
Aiming at the information asymmetry between pharmaceutical enterprises’ technological innovation decisions and government subsidy strategy, this paper establishes a differential game model consisting of the government and a single pharmace…
View article: 6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging
6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging Open
Disclosure: K. Yu: None. J. Saini: None. J.N. Farr: None. F. Vanessa: None. S. Khosla: None. I. Bancos: Advisory Board Member; Self; AstraZeneca, Adrenas, Neurocrine, Spruce, Recordati, Xeris, Novo Nordisk, HRA Pharmaceuticals, Sparrow, Di…
View article: Reverse remodeling of mitral leaflets after medical treatment in recent-onset dilated cardiomyopathy
Reverse remodeling of mitral leaflets after medical treatment in recent-onset dilated cardiomyopathy Open
Enlarged MLs could reverse accompanied by LV reverse remodeling. This study provided the other facet of ML plasticity adaptive to mechanical stretching.
View article: Nissist: An Incident Mitigation Copilot based on Troubleshooting Guides
Nissist: An Incident Mitigation Copilot based on Troubleshooting Guides Open
Effective incident management is pivotal for the smooth operation of enterprises-level cloud services. In order to expedite incident mitigation, service teams compile troubleshooting knowledge into Troubleshooting Guides (TSGs) accessible …
View article: Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Coronary Artery Disease Patients with Different Glucose Metabolism Status
Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Coronary Artery Disease Patients with Different Glucose Metabolism Status Open
Background: Abnormal glucose metabolism is present in most patients with coronary artery disease (CAD). Inflammation is considered to be a common risk factor for CAD and diabetes. Fibrinogen-to-albumin ratio (FAR), a novel inflammation bio…
View article: IMPROVED EFFICACY AND SAFETY OF ZANUBRUTINIB VERSUS IBRUTINIB IN PATIENTS WITH RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (R/R CLL) IN CHINA: A SUBGROUP OF ALPINE
IMPROVED EFFICACY AND SAFETY OF ZANUBRUTINIB VERSUS IBRUTINIB IN PATIENTS WITH RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (R/R CLL) IN CHINA: A SUBGROUP OF ALPINE Open
Introduction: Zanubrutinib is an irreversible, potent, next-generation Bruton tyrosine kinase (BTK) inhibitor designed to maximize BTK occupancy and minimize off-target inhibition. In a randomized phase 3 study (ALPINE; NCT03734016), zanub…
View article: Combined inhibition of <scp>XIAP</scp> and autophagy induces apoptosis and differentiation in acute myeloid leukaemia
Combined inhibition of <span>XIAP</span> and autophagy induces apoptosis and differentiation in acute myeloid leukaemia Open
Perturbations in autophagy, apoptosis and differentiation have greatly affected the progression and therapy of acute myeloid leukaemia (AML). The role of X‐linked inhibitor of apoptosis (XIAP)‐related autophagy remains unclear in AML thera…
View article: Figures S1-S6, Table S1-S3 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction
Figures S1-S6, Table S1-S3 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction Open
Fig. S1. Sustained adrenergic signaling increases nerve counts in tumors. Fig. S2. Characterization of tumoral innervation. Fig. S3. NE induces BDNF expression. Fig. S4. NE-induced BDNF expression is mediated by ADRB3/Epac/Jnk. Fig. S5. BD…
View article: Figures S1-S6, Table S1-S3 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction
Figures S1-S6, Table S1-S3 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction Open
Fig. S1. Sustained adrenergic signaling increases nerve counts in tumors. Fig. S2. Characterization of tumoral innervation. Fig. S3. NE induces BDNF expression. Fig. S4. NE-induced BDNF expression is mediated by ADRB3/Epac/Jnk. Fig. S5. BD…
View article: Supplementary information from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma
Supplementary information from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma Open
PDF file 106K, Table S1. Molecules whose expression significantly differed between cells treated with KX-01 and control cells in RMUG-S cells Table S2. Molecules whose expression significantly differed between cells treated with KX-01 and …
View article: Supplementary Movie 1 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction
Supplementary Movie 1 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction Open
CARS imaging of ex vivo ovarian cancer samples
View article: Supplementary Movie 1 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction
Supplementary Movie 1 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction Open
CARS imaging of ex vivo ovarian cancer samples
View article: Figure S2 from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma
Figure S2 from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma Open
PDF file 196K, Figure S2. Effects of KX-01 and oxaliplatin on cell proliferation (Ki-67; A), angiogenesis (CD31; B), apoptosis (Cleaved caspase-3; C) RMUG-L model. Original magnification 200x . Bars in the graphs correspond sequentially to…
View article: Figure S2 from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma
Figure S2 from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma Open
PDF file 196K, Figure S2. Effects of KX-01 and oxaliplatin on cell proliferation (Ki-67; A), angiogenesis (CD31; B), apoptosis (Cleaved caspase-3; C) RMUG-L model. Original magnification 200x . Bars in the graphs correspond sequentially to…
View article: Supplementary Movie 2 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction
Supplementary Movie 2 from Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction Open
CARS imaging of ex vivo ovarian cancer samples
View article: Supplementary information from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma
Supplementary information from Targeting Src and Tubulin in Mucinous Ovarian Carcinoma Open
PDF file 106K, Table S1. Molecules whose expression significantly differed between cells treated with KX-01 and control cells in RMUG-S cells Table S2. Molecules whose expression significantly differed between cells treated with KX-01 and …
View article: The impact of circulating IGF-1 and IGFBP-2 on cardiovascular prognosis in patients with acute coronary syndrome
The impact of circulating IGF-1 and IGFBP-2 on cardiovascular prognosis in patients with acute coronary syndrome Open
Background While insulin-like growth factor 1 (IGF-1) exerts a cardioprotective effect in the setting of atherosclerosis, insulin-like growth factor binding protein 2 (IGFBP-2) is involved in metabolic syndrome. Although IGF-1 and IGFBP-2 …
View article: The circ_0002538/miR-138-5p/plasmolipin axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy
The circ_0002538/miR-138-5p/plasmolipin axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy Open
Circular RNAs (circRNAs) play a vital role in diabetic peripheral neuropathy. However, their expression and function in Schwann cells in individuals with diabetic peripheral neuropathy remain poorly understood. Here, we performed protein p…
View article: Long term complete response of advanced hepatocellular carcinoma to glypican-3 specific chimeric antigen receptor T-Cells plus sorafenib, a case report
Long term complete response of advanced hepatocellular carcinoma to glypican-3 specific chimeric antigen receptor T-Cells plus sorafenib, a case report Open
The clinical efficacy of current therapies for Hepatocellular carcinoma (HCC) are unsatisfactory. In recent years, chimeric antigen receptor (CAR) T-cell therapies have been developed for solid tumors including advanced HCC (aHCC), but lim…
View article: A novel BCMA CAR-T-cell therapy with optimized human scFv for treatment of relapsed/refractory multiple myeloma: results from phase I clinical trials
A novel BCMA CAR-T-cell therapy with optimized human scFv for treatment of relapsed/refractory multiple myeloma: results from phase I clinical trials Open
Not available.
View article: Evidence for ABL Amplification in Multiple Myeloma and Therapeutic Implications
Evidence for ABL Amplification in Multiple Myeloma and Therapeutic Implications Open
Background. Cytogenetic abnormalities are considered initiating events in the pathogenesis of multiple myeloma (MM) and are assumed to be of clinical significance. Methods. Fluorescence in situ hybridization (FISH) was used to analyze chro…