Kyle Kuszpit
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View article: GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice
GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice Open
An early driver of Type 2 diabetes mellitus (T2D) is ectopic fat accumulation, especially in the liver, that impairs insulin sensitivity. In T2D, GLP-1R/GCGR dual-agonists reduce glycaemia, body weight and hepatic steatosis. Here, we utili…
View article: Supplementary Figures 1-3 from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
Supplementary Figures 1-3 from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells Open
PDF file - 77K
View article: Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity Open
Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
View article: Data from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
Data from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells Open
Purpose: [18F]FLT (3′-Fluoro-3′ deoxythymidine)–PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [18F]FLT–PET imaging …
View article: Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts Open
Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
View article: Data from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
Data from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity Open
Purpose: P-cadherin is a membrane glycoprotein that functionally mediates tumor cell adhesion, proliferation, and invasiveness. We characterized the biological properties of PF-03732010, a human monoclonal antibody against P-cadheri…
View article: Data from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
Data from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity Open
Purpose: P-cadherin is a membrane glycoprotein that functionally mediates tumor cell adhesion, proliferation, and invasiveness. We characterized the biological properties of PF-03732010, a human monoclonal antibody against P-cadheri…
View article: Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity Open
Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
View article: Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts Open
Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
View article: Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts Open
Purpose: Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage checkpoint. We examined the preclinical use of the Chk1 inhibitor PF-00477736 as a docetaxel-sensitizing agent.…
View article: CCR Translation for This Article from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
CCR Translation for This Article from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells Open
CCR Translation for This Article from [18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
View article: Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts Open
Purpose: Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage checkpoint. We examined the preclinical use of the Chk1 inhibitor PF-00477736 as a docetaxel-sensitizing agent.…
View article: Data from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
Data from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells Open
Purpose: [18F]FLT (3′-Fluoro-3′ deoxythymidine)–PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [18F]FLT–PET imaging …
View article: CCR Translation for This Article from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
CCR Translation for This Article from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells Open
CCR Translation for This Article from [18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
View article: Supplementary Figures 1-3 from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
Supplementary Figures 1-3 from [<sup>18</sup>F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells Open
PDF file - 77K
View article: Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation
Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation Open
Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and parti…
View article: Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics
Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics Open
Critical bacterial pathogens of public health and biodefense concerns were engineered to constitutively express Escherichia coli enzyme thymidine kinase (TK) that allows for noninvasive nuclear imaging via phosphorylation and entrapment of…
View article: Evaluation of Volume of Intramuscular Injection into the Caudal Thigh Muscles of Female and Male BALB/c Mice (<i>Mus musculus</i>).
Evaluation of Volume of Intramuscular Injection into the Caudal Thigh Muscles of Female and Male BALB/c Mice (<i>Mus musculus</i>). Open
This study presents recommendations for intramuscular injection into the caudal thigh muscle of mice according to analysis of in vivo imaging of intramuscularly injected iohexol, a radiocontrast agent commonly used in CT imaging. An experi…
View article: [18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice
[18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice Open
View article: Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon
Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon Open
Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morb…