Kyle Leix
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View article: Functional interrogation of candidate<i>cis</i>-regulatory elements at the<i>LDLR</i>locus
Functional interrogation of candidate<i>cis</i>-regulatory elements at the<i>LDLR</i>locus Open
Regulation of LDLR gene expression plays an important role in the development of atherosclerotic diseases including heart attack and stroke. Although LDLR regulation by sterol response elements has been well characterized, the functional s…
View article: Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection
Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection Open
Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from prog…
View article: Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection
Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection Open
Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from prog…
View article: The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes
The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes Open
We examined the role of Gcg on β-cell function under normal and high glucose conditions. GcgNull mice had decreased glucose-stimulated insulin secretion, increased β-cell mass, and partial protection against STZ-induced hyperglycemia. Expr…
View article: Identification of cell type specific ACE2 modifiers by CRISPR screening
Identification of cell type specific ACE2 modifiers by CRISPR screening Open
SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both in vivo and in immortalized cell lines, but the molecular pathways that gove…
View article: Diet-dependent sex differences in the response to vertical sleeve gastrectomy
Diet-dependent sex differences in the response to vertical sleeve gastrectomy Open
These data highlight the interaction of postsurgical diet after bariatric surgery on metabolic outcomes across sexes. These data suggest the impact of VSG on hepatic triglycerides is diet-dependent in females and support the hypothesis tha…
View article: The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice
The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice Open