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View article: Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation
Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation Open
Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. It's use in immunomodulatory therapies has faced limitations due to challenges in controlled delivery and requirements of high extracellular con…
View article: Persistent glycolysis defines the foreign body response to polymeric implants
Persistent glycolysis defines the foreign body response to polymeric implants Open
Non-degradable polymeric implantable medical devices are a mainstay of modern healthcare but can frequently lead to severe complications. These complications are largely attributable to the foreign body response ( FBR ), which is character…
View article: Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation
Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation Open
Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. Its use in immunomodulatory therapies has faced limitations due to inherent challenges in achieving controlled delivery and requirements for hig…
View article: Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility
Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility Open
Profiling cellular metabolism in the FBR could identify novel therapeutic targets and promote biocompatibility.