Kyle Metz
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View article: C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways Open
All cells contain specialized signaling pathways that enable adaptation to specific molecular stressors. Yet, whether these pathways are centrally regulated in complex physiological stress states remains unclear. Using genome-scale fitness…
View article: HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state
HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state Open
Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR), where it drives a transcriptional program comprising heat shock protein (HSP) genes, and in tumorigenesis, where it drives a program comprising HSPs an…
View article: Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response
Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response Open
Summary The interrelated programs essential for cellular fitness in the face of stress are critical to understanding tumorigenesis, neurodegeneration, and aging. However, modelling the combinatorial landscape of stresses experienced by dis…
View article: <i>KCTD</i>: A new gene family involved in neurodevelopmental and neuropsychiatric disorders
<i>KCTD</i>: A new gene family involved in neurodevelopmental and neuropsychiatric disorders Open
The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not appr…
View article: <i>KCTD7</i> deficiency defines a distinct neurodegenerative disorder with a conserved autophagy‐lysosome defect
<i>KCTD7</i> deficiency defines a distinct neurodegenerative disorder with a conserved autophagy‐lysosome defect Open
Objective Several small case series identified KCTD7 mutations in patients with a rare autosomal recessive disorder designated progressive myoclonic epilepsy (EPM3) and neuronal ceroid lipofuscinosis (CLN14). Despite the name KCTD (potassi…
View article: Whi2 is a conserved negative regulator of TORC1 in response to low amino acids
Whi2 is a conserved negative regulator of TORC1 in response to low amino acids Open
Yeast WHI2 was originally identified in a genetic screen for regulators of cell cycle arrest and later suggested to function in general stress responses. However, the function of Whi2 is unknown. Whi2 has predicted structure and sequence s…
View article: A Geologic Study to Determine the Potential to Create an Appalachian Storage Hub for Natural Gas Liquids
A Geologic Study to Determine the Potential to Create an Appalachian Storage Hub for Natural Gas Liquids Open
The Marcellus and Utica shale plays continue to lead the way in an ever-expanding shale revolution with average daily production, growing from about 3 billion cubic feet (BCF) in 2010 to more than 24 BCF today. Forecasts suggest that this …