Kyle Costa
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View article: Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury
Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury Open
Spinal cord injury (SCI) evokes profound dysfunction in hollow organs such as the urinary bladder and gut. Current treatments are limited by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed that systemic …
View article: Integrated omics analysis unveils a DNA damage response to neurogenic injury
Integrated omics analysis unveils a DNA damage response to neurogenic injury Open
Spinal cord injury (SCI) evokes profound bladder dysfunction. Current treatments are limited by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed systemic inosine treatment improved bladder function follow…
View article: Evaluation of silk fibroin-based urinary conduits in a porcine model of urinary diversion
Evaluation of silk fibroin-based urinary conduits in a porcine model of urinary diversion Open
Background: The primary strategy for urinary diversion in radical cystectomy patients involves incorporation of autologous gastrointestinal conduits into the urinary tract which leads to deleterious consequences including chronic infection…
View article: Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model
Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model Open
Surgical reconstruction of tubular esophageal defects with autologous gastrointestinal segments is the gold standard treatment to replace damaged or diseased esophageal tissues. Unfortunately, this approach is associated with adverse compl…
View article: Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts
Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts Open
The ability of bi-layer silk fibroin (BLSF) matrices to mediate functional tissue formation in porcine bladders subjected to acute partial bladder outlet obstruction (pBOO) was investigated. Sixteen female swine were fitted with a transien…
View article: Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair
Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair Open
The bladder urothelium functions as a urine-blood barrier and consists of basal, intermediate, and superficial cell populations. Reconstructive procedures such as augmentation cystoplasty and focal mucosal resection involve localized surgi…
View article: MP30-09 BI-LAYER SILK FIBROIN GRAFTS PROMOTE TISSUE REGENERATION IN A FETAL OVINE MODEL OF BLADDER EXSTROPHY
MP30-09 BI-LAYER SILK FIBROIN GRAFTS PROMOTE TISSUE REGENERATION IN A FETAL OVINE MODEL OF BLADDER EXSTROPHY Open
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology II1 Apr 2016MP30-09 BI-LAYER SILK FIBROIN GRAFTS PROMOTE TISSUE REGENERATION IN A FETAL OVINE MODEL OF BLADDER EXSTROPHY Saif Affas, Khalid Algarrahi, D…