Kyle R. Covington
YOU?
Author Swipe
View article: Early Genetic Evolution of Driver Mutations in Uveal Melanoma
Early Genetic Evolution of Driver Mutations in Uveal Melanoma Open
Uveal melanoma (UM) is an aggressive cancer of the eye that frequently results in metastatic death. UMs are most likely to metastasize when they are small, at a time when they are difficult to distinguish from benign nevi and often observe…
View article: Predicting adjuvant radiation therapy benefit in cutaneous squamous cell carcinoma with the 40-gene expression profile
Predicting adjuvant radiation therapy benefit in cutaneous squamous cell carcinoma with the 40-gene expression profile Open
Aim: To independently confirm that the 40-gene expression profile (40-GEP) test can identify patients with high-risk cutaneous squamous cell carcinoma who are more or less likely to benefit from adjuvant radiation therapy (ART).M…
View article: 31-Gene Expression Profile Testing in Cutaneous Melanoma and Survival Outcomes in a Population-Based Analysis: A SEER Collaboration
31-Gene Expression Profile Testing in Cutaneous Melanoma and Survival Outcomes in a Population-Based Analysis: A SEER Collaboration Open
PURPOSE The DecisionDx-Melanoma 31-gene expression profile (31-GEP) test is validated to classify cutaneous malignant melanoma (CM) patient risk of recurrence, metastasis, or death as low (class 1A), intermediate (class 1B/2A), or high (cl…
View article: Data from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
Data from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma Open
Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little is currently known about the mutations that drive aggressive cSCC.Experimental Design: Whole-exome sequencing…
View article: Supplementary Table Set S11-S18 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set S11-S18 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S11. 80 Gene Signature for NMF Cluster 1 (LAR). Table S12. 80 Gene Signature for NMF Cluster 2 (MES). Table S13. 80 Gene Signature for NMF Cluster 3 (BLIS). Table S14. 80 Gene Signature for NMF Cluster 4 (BLIA). Table S15. Assignment…
View article: Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Table S1 shows Clinical features. Table S2 shows Patient/sample information and NGS statistics. Table S3 shows Methylation status of CpG sites of WNT targets with CTNNB1 mutation. Table S4 shows Chromosomal aberrations.
View article: Supplementary Table Set S36-S39 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set S36-S39 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S36. Differentially Expressed Genes (>2 fold) Present in Pathways, Regulator Networks, or DNA-Correlated in Subtype 1 (LAR). Table S37. Differentially Expressed Genes (>2 fold) Present in Pathways, Regulator Networks, or DNA-Correlat…
View article: Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Supplementary Figure legends
View article: Data from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells
Data from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Open
Purpose: Tamoxifen (Tam) is the most prescribed hormonal agent for treatment of estrogen receptor α (ERα)-positive breast cancer patients. Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy…
View article: Supplemental Figures and Methods from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
Supplemental Figures and Methods from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma Open
Supplemental Figures S1-S2 and Methods. Figure S1: Mutation types and number by previous radiation treatment. Figure S2: Copy number alterations.
View article: Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Figure S1 shows Histological findings of stepwise hepatocarcinogenesis and somatic substitution patterns. Figure S2 shows Activation of WNT targets. Figure S3 shows Homozygous deletion in 4q and 16q. Figure S4 shows Circos plot and transcr…
View article: Supplemental Figures and Methods from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
Supplemental Figures and Methods from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma Open
Supplemental Figures S1-S2 and Methods. Figure S1: Mutation types and number by previous radiation treatment. Figure S2: Copy number alterations.
View article: Supplemental Tables S1-S4 and S6-S13 from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
Supplemental Tables S1-S4 and S6-S13 from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma Open
Supplemental Tables S1-S4 and S6-S13. Supplemental Table S1: Summary of Patient Characteristics. Supplemental Table S2: Patient Characteristics and Key Mutations. Supplemental Table S3: Tumor purity and ploidy calculations. Supplemental Ta…
View article: Supplementary Table Set S19-S22 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set S19-S22 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S19. Assignment of Curtis Set Clusters by Discovery Set Centroids. Table S20. Assignment of Sabatier Set Clusters by Discovery Set Centroids. Table S21. Summary of Subtype Assignment by Data Set. Table S22. Comparison of Subtype Assi…
View article: Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Supplementary Figure legends
View article: Supplementary Figure S1-S9 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Figure S1-S9 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Figure S1. Full clustering metrics in support of a 4 cluster model in the discovery set with membership as defined by TNBCType. Figure S2. Full clustering metrics in support of a 4 cluster model in the validation set with membership as def…
View article: Supplementary Table Set S23-S24 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set S23-S24 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S23. CoxPH Models for Sabatier Set Table S24. CoxPH Models for Curtis Set
View article: Supplementary Table Set S23-S24 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set S23-S24 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S23. CoxPH Models for Sabatier Set Table S24. CoxPH Models for Curtis Set
View article: Supplementary Table Set S19-S22 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set S19-S22 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S19. Assignment of Curtis Set Clusters by Discovery Set Centroids. Table S20. Assignment of Sabatier Set Clusters by Discovery Set Centroids. Table S21. Summary of Subtype Assignment by Data Set. Table S22. Comparison of Subtype Assi…
View article: Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Figure S1 shows Histological findings of stepwise hepatocarcinogenesis and somatic substitution patterns. Figure S2 shows Activation of WNT targets. Figure S3 shows Homozygous deletion in 4q and 16q. Figure S4 shows Circos plot and transcr…
View article: Supplementary Table Set - S1-S10 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Supplementary Table Set - S1-S10 from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Table S1. Differentially Expressed Genes for NMF Cluster 1 (LAR). Table S2. Differentially Expressed Genes for NMF Cluster 2 (MES). Table S3. Differentially Expressed Genes for NMF Cluster 3 (BLIS). Table S4. Differentially Expressed Genes…
View article: Supplementary Figure Legend from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells
Supplementary Figure Legend from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Open
PDF file - 69KB
View article: Supplementary Figures 1 - 3 from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells
Supplementary Figures 1 - 3 from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Open
PDF file - 1575KB
View article: Data from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Data from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Purpose: Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and identify subtype-specific markers and targets.Experimental Desi…
View article: Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Table S1 shows Clinical features. Table S2 shows Patient/sample information and NGS statistics. Table S3 shows Methylation status of CpG sites of WNT targets with CTNNB1 mutation. Table S4 shows Chromosomal aberrations.
View article: Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Cancer develops through the accumulation of genetic and epigenetic aberrations. To identify sequential molecular alterations that occur during the development of hepatocellular carcinoma (HCC), we compared 52 early and 108 overt HCC sample…
View article: Supplementary Figures 1 - 3 from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells
Supplementary Figures 1 - 3 from Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Open
PDF file - 1575KB
View article: Data from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Data from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer Open
Purpose: Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and identify subtype-specific markers and targets.Experimental Desi…
View article: Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression Open
Cancer develops through the accumulation of genetic and epigenetic aberrations. To identify sequential molecular alterations that occur during the development of hepatocellular carcinoma (HCC), we compared 52 early and 108 overt HCC sample…
View article: Supplemental Table S5 from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
Supplemental Table S5 from Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma Open
Supplemental Table S5: mutation annotation file.