Explanipedia

A Mixed-Methods Scoping Review on Bladder Self-Care Practices in Women With and Without Lower Urinary Tract Symptoms Open

Jean F. Wyman, Diane K. Newman, Amy M. Claussen, Julia Geynisman‐Tan, Ann Stapleton , et al. · 2025

Bladder health and the urogenital microbiome in community-dwelling adult females Open

Linda Brubaker, Daniel McDonald, S. Putnam, Caitriona Brennan, Cynthia S. Fok , et al. · 2025

Despite the established association with lower urinary tract symptoms, the relationship between a healthy bladder and the urogenital microbiome is unknown. This observational cohort study of 435 community-dwelling women examined bladder he…

Proximal vs. distal colon cancer location: a subset analysis of the Minnesota colon cancer control study Open

Alexander Troester, Claire Sokas, Jack M. Wolf, Kyle Rudser, Timothy R. Church , et al. · 2025

Although lacking granular data, these findings from the pre-modern chemotherapy era raise questions about the generalizability of the association between side of origin and prognosis identified in contemporary, treatment-based trials.

Predictors of BMI reduction with phentermine/topiramate in adolescents with obesity Open

Megan O. Bensignor, Rebecca Freese, Kyle Rudser, Aaron S. Kelly, Alicia Kunin‐Batson , et al. · 2025

Advanced Adenoma and Long-Term Risk of Colorectal Cancer, Cancer-Related Mortality, and Mortality Open

Aasma Shaukat, Paolo Goffredo, Jack M. Wolf, Kyle Rudser, Timothy R. Church · 2025

This cohort study investigates the association of adenomas and advanced adenomas with colorectal cancer (CRC) incidence and mortality and all-cause mortality.

Diffusion tensor imaging with free‐water correction reveals distinctions between severe and attenuated subtypes in Mucopolysaccharidosis type I Open

Alena Svátková, Ofer Pasternak, Julie B. Eisengart, Kyle Rudser, Petr Bednařík , et al. · 2025

Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder leading to deleterious brain effects. While animal models suggested that MPS I severely affects white matter (WM), whole‐brain diffusion tensor imaging (DTI) a…

241 - BLADDER HEALTH IN WOMEN: POPULATION-BASED ESTIMATES FROM THE US-BASED RISE FOR HEALTH STUDY Open

Siobhan Sutcliffe, Conner Falke, Kyle Rudser, Gerald McGwin, Sonya S. Brady , et al. · 2024

Financial Incentives and Treatment Outcomes in Adolescents With Severe Obesity Open

Amy C. Gross, Rebecca Freese, Megan O. Bensignor, Eric M. Bomberg, Donald R. Dengel , et al. · 2024

Importance Adolescent severe obesity is usually not effectively treated with traditional lifestyle modification therapy. Meal replacement therapy (MRT) shows short-term efficacy for body mass index (BMI; calculated as weight in kilograms d…

Effectiveness and predictors of weight loss response to phentermine plus lifestyle modifications among youth in a paediatric weight management clinical setting Open

Eric M. Bomberg, Justin Clark, Kyle Rudser, Amy C. Gross, Aaron S. Kelly , et al. · 2024

Summary Background Anti‐obesity medications (AOMs) are promising lifestyle modification (LSM) adjuncts for obesity treatment, and phentermine is commonly prescribed in paediatric weight management clinics. Determining ‘real‐world’ AOM effe…

Clinical effectiveness and predictors of response to topiramate plus lifestyle modification in youth with obesity seen in a weight management clinical setting Open

Eric M. Bomberg, Justin Clark, Kyle Rudser, Amy C. Gross, Aaron S. Kelly , et al. · 2024

Introduction Obesity affects approximately 20% of U.S. youth. Anti-obesity medications (AOMs) are promising lifestyle modification adjuncts for obesity treatment, and topiramate is commonly prescribed in pediatric weight management clinics…

Evaluating appetite/satiety hormones and eating behaviours as predictors of weight loss maintenance with <span>GLP‐1RA</span> therapy in adolescents with severe obesity Open

Megan O. Bensignor, Aaron S. Kelly, Alicia Kunin‐Batson, Claudia K. Fox, Rebecca Freese , et al. · 2024

Summary Introduction Whilst glucagon‐like peptide‐1 receptor agonists (GLP1‐RAs) are effective for treating adolescent obesity, weight loss maintenance (WLM; preventing weight regain) remains a challenge. Our goal was to investigate appeti…

Is there an association between physical activity and lower urinary tract symptoms in adolescent girls? Results from the Avon Longitudinal Study of Parents and Children Open

Colleen M. Fitzgerald, Shayna D. Cunningham, Amanda Berry, Sheila Gahagan, Carol Joinson , et al. · 2023

Comparison of Laryngeal Mask Airway and Endotracheal Tube Placement in Neonates Open

Kari E. Roberts, Amanda A. Wanous, Roland Brown, Kyle Rudser · 2023

Objective We hypothesize that the time, number of attempts and physiologic stability of placement of an LMA would be superior compared to ETT. Study Design: Videotape and physiologic parameters of LMA (n = 36) and ETT (n = 31) placement pr…

Healthy bladder storage and emptying functions in community‐dwelling women measured by a 2‐day bladder health diary Open

Emily S. Lukacz, Chloe Falke, Julia Geynisman‐Tan, Jean F. Wyman, Elizabeth R. Mueller , et al. · 2023

Introduction The prevalence of healthy bladder storage and emptying function in community‐dwelling women is not well established. Methods A planned secondary analysis of a US cross‐sectional study designed to validate a bladder health inst…

Comprehensive pelvic muscle assessment: Developing and testing a dual e‐Learning and simulation‐based training program Open

Diane K. Newman, Jerry L. Lowder, Melanie Meister, Lisa Kane Low, Colleen M. Fitzgerald , et al. · 2023

Objective The Prevention of Lower Urinary Tract Symptoms (PLUS) research consortium launched the RISE FOR HEALTH (RISE) national study of women's bladder health which includes annual surveys and an in‐person visit. For the in‐person exam, …

Validation of bladder health scales and function indices for women’s research Open

Melissa L. Constantine, Todd Rockwood, Leslie Rickey, Tamara Bavendam, Lisa Kane Low , et al. · 2022

The RISE FOR HEALTH study: Methods for in‐person assessment and biospecimen collection Open

Linda Brubaker, Julia Barthold, Colleen M. Fitzgerald, Kimberly Kenton, Cora E. Lewis , et al. · 2022

Objectives To describe the methods for the in‐person assessment of the RISE FOR HEALTH (RISE) study, a population‐based multicenter prospective cohort study designed to identify factors that promote bladder health and/or prevent lower urin…

Need for Public Health Messaging Related to Bladder Health from Adolescence to Advanced Age Open

Kathryn L. Burgio, Shayna D. Cunningham, Diane K. Newman, Lisa Kane Low, Jesse Nodora , et al. · 2022

Objective: The purpose of this analysis was to explore adolescent and adult women's interest in public health messaging around bladder health and perceptions of its usefulness. Materials and Methods: Directed co…

The RISE FOR HEALTH study: Methods for in‐person musculoskeletal assessment Open

Colleen M. Fitzgerald, Cynthia S. Fok, Kim Kenton, Emily S. Lukacz, Alayne D. Markland , et al. · 2022

Objectives To describe the methods for the in‐person musculoskeletal (MSK) assessment of the RISE FOR HEALTH (RISE) study, a population‐based multicenter prospective cohort study designed to identify factors associated with bladder health …

Relationship of Endothelial Microparticles to Obesity and Cardiovascular Disease Risk in Children and Adolescents Open

Subin Jang, Elise F. Palzer, Kyle Rudser, Claudia K. Fox, Robert P. Hebbel , et al. · 2022

Background Microparticles and endothelial microparticles (EMPs) are implicated in accelerating cardiovascular disease (CVD); however, data in pediatrics are limited. We examined the relationship of microparticles and EMPs with adiposity an…

RISE FOR HEALTH: Rationale and protocol for a prospective cohort study of bladder health in women Open

Ariana L. Smith, Kyle Rudser, Bernard L. Harlow, Gerald McGwin, Julia Barthold , et al. · 2022

Introduction The spectrum of bladder health and the factors that promote bladder health and prevent lower urinary tract symptoms (LUTS) among women are not well understood. This manuscript describes the rationale, aims, study design, sampl…

A policy toolkit for authorship and dissemination policies may benefit NIH research consortia Open

Linda Brubaker, Jesse Nodora, Tamara Bavendam, John E. Connett, Amy M. Claussen , et al. · 2022

Authorship and dissemination policies vary across NIH research consortia. We aimed to describe elements of real-life policies in use by eligible U01 clinical research consortia. Principal investigators of eligible, active U01 clinical rese…

Biological Variation in Peripheral Inflammation and Oxidative Stress Biomarkers in Individuals with Gaucher Disease Open

Siddhee A. Sahasrabudhe, Márcia R. Terluk, Kyle Rudser, James C. Cloyd, Reena V. Kartha · 2022

The lack of reliable biomarkers is a significant challenge impeding progress in orphan drug development. For appropriate interpretation of intervention-based results or for evaluating candidate biomarkers, other things being equal, lower v…

<span>Glucagon‐like</span> peptide‐1 receptor agonist prescribing patterns in adolescents with type 2 diabetes Open

Megan O. Bensignor, Jack M. Wolf, Kyle Rudser, Aaron S. Kelly, Silva Arslanian · 2022

Type 2 diabetes (T2D) in youth is a more aggressive disease that is associated with earlier co-morbidities compared with T2D in adulthood.1 Treatment guidelines for paediatric T2D first recommend lifestyle management and metformin, which r…

Exenatide for weight‐loss maintenance in adolescents with severe obesity: A randomized, placebo‐controlled trial Open

Claudia K. Fox, Justin Clark, Kyle Rudser, Justin R. Ryder, Amy C. Gross , et al. · 2022

Objective This study sought to evaluate the effect of 52 weeks of exenatide extended release (XR) on the maintenance of meal replacement therapy (MRT)‐induced BMI reduction in adolescents with severe obesity. Methods In this randomized, do…

Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury Open

Catarina Saiote, Ellen N. Sutter, Annette Xenopoulos-Oddsson, Raghavendra Rao, Michael Georgieff , et al. · 2022

Purpose: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), t…

Quantitative brain MRI morphology in severe and attenuated forms of mucopolysaccharidosis type I Open

Victor Kovac, Elsa Shapiro, Kyle Rudser, Bryon A. Mueller, Julie B. Eisengart , et al. · 2022

Design Considerations and Analytical Framework for Reliably Identifying a Beneficial Individualized Treatment Rule Open

Charles Cain, Thomas A. Murray, Kyle Rudser, Alexander J. Rothman, Anne C. Melzer , et al. · 2022

Anti-obesity medication prescriptions by race/ethnicity and use of an interpreter in a pediatric weight management clinic Open

Eric M. Bomberg, Elise F. Palzer, Kyle Rudser, Aaron S. Kelly, Carolyn T. Bramante , et al. · 2022

Background: Race/ethnicity and low English proficiency healthcare disparities are well established in the United States. We sought to determine if there are race/ethnicity differences in anti-obesity medication (AOM) prescription rates amo…

Changes in Bladder Health over Time: A Longitudinal Analysis of Adult Women in the Boston Area Community Health Survey Open

Siobhan Sutcliffe, Charles Cain, Tamara Bavendam, Colleen M. Fitzgerald, Sheila Gahagan , et al. · 2021

Findings from our large secondary analysis of BACH Survey data suggest considerable variability in bladder health over time, and underscore the importance of bladder health promotion to prevent the initial onset and progression of poor bla…

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