Explanipedia

Upper respiratory tract microbiota dynamics following COVID-19 in adults Open

Christian Rosas‐Salazar, Kyle S. Kimura, Meghan H. Shilts, Britton A. Strickland, M.H. Freeman , et al. · 2023

To date, little is known about the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, on the upper respiratory tract (URT) microbiota over tim…

Mucosal Gene Expression in Response to SARS-CoV-2 Is Associated with Viral Load Open

Seesandra V. Rajagopala, Britton A. Strickland, Suman Pakala, Kyle S. Kimura, Meghan H. Shilts , et al. · 2023

Several prior studies have shown that SARS-CoV-2 viral load can predict the likelihood of disease spread and severity. A higher detectable SARS-CoV-2 plasma viral load was associated with worse respiratory disease severity.

Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial Open

Charles R. Esther, Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das , et al. · 2023

BACKGROUND: The nose is the portal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, suggesting the nose as a target for topical antiviral therapies. The purpose of this study was to assess both the in vivo and in…

Mucosal gene expression in response to SARS-CoV-2 is associated with early viral load Open

Seesandra V. Rajagopala, Britton A. Strickland, Suman Pakala, Kyle S. Kimura, Meghan H. Shilts , et al. · 2022

Little is known about the relationships between symptomatic early-time SARS-CoV-2 viral load and upper airway mucosal gene expression and immune response. To examine the association of symptomatic SARS-CoV-2 early viral load with upper air…

Trends in Maxillofacial Trauma During COVID-19 at a Level 1 Trauma Center Open

Elizabeth S. Longino, Kelly C. Landeen, Bronson C. Wessinger, Kyle S. Kimura, Seth J. Davis , et al. · 2022

Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome Open

Meghan H. Shilts, Christian Rosas‐Salazar, Britton A. Strickland, Kyle S. Kimura, Mohammad Asad , et al. · 2022

Background The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations betwee…

Pharmacokinetic‐based failure of a detergent virucidal for severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) nasal infections: A preclinical study and randomized controlled trial Open

Charles R. Esther, Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das , et al. · 2022

Background The nose is the portal for severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) infection, suggesting the nose as a target for topical antiviral therapies. The purpose of this study was to assess both the in vivo and in …

Modeling Recurrence in Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow Open

Kyle S. Kimura, Liping Du, Lynn D. Berry, Li‐Ching Huang, Sheau‐Chiann Chen , et al. · 2021

Objectives/Hypothesis We sought to establish normative peak expiratory flow (PEF) data for patients with idiopathic subglottic stenosis (iSGS), evaluate whether immediate changes in PEF after a procedure predict long‐term treatment respons…

Corrigendum to ‘Undetectable viral load within the mastoid during cochlear implantation in a patient with Covid-19’ Open

Kyle S. Kimura, Miriam R. Smetak, M. A. R. Freeman, Christopher T. Wootten · 2021

Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections Open

Charles R. Esther, Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das , et al. · 2021

The nose is the portal for SARS-CoV-2 infection, suggesting the nose as a target for topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson’s Baby Shampoo (J&J) was tested as a topical virucidal agent in SARS-Co…

Undetectable viral load within the mastoid during cochlear implantation in a patient with COVID-19 Open

Kyle S. Kimura, Miriam R. Smetak, M.H. Freeman, Christopher T. Wootten · 2021

SARS-CoV-2 infection and viral load are associated with the upper respiratory tract microbiome Open

Christian Rosas‐Salazar, Kyle S. Kimura, Meghan H. Shilts, Britton A. Strickland, M.H. Freeman , et al. · 2021

Disseminated Herpes Simplex Infection Presenting as Acute Supraglottitis in an Adult Open

Eve M. R. Bowers, Brandon I. Esianor, Kyle S. Kimura, James S. Lewis, Michael C. Topf · 2020

New-onset seizures following cochlear implantation reprogramming – A case report Open

Kyle S. Kimura, Siddharth Patel, M.H. Freeman, Alejandro Rivas · 2020

Background: Cochlear implant (CI) soft failures are relatively rare and have wide-ranging presentations. We present a CI soft failure case that manifested with facial pain and auditory clicking which progressed to severe spasmodic episodes…

Interim analysis of an open‐label randomized controlled trial evaluating nasal irrigations in non‐hospitalized patients with coronavirus disease 2019 Open

Kyle S. Kimura, M.H. Freeman, Bronson C. Wessinger, Veerain Gupta, Quanhu Sheng , et al. · 2020

Response to the coronavirus disease 2019 (COVID-19) pandemic has primarily focused on pharmacologic and medical interventions, including antivirals,1 convalescent sera,2 and vaccinations,3 with each potentially critical in the fight agains…

Unilateral Vocal Fold Immobility After Prolonged Endotracheal Intubation Open

Benjamin R. Campbell, Justin R. Shinn, Kyle S. Kimura, Anne S. Lowery, Jonathan D. Casey , et al. · 2019

Unilateral vocal fold immobility occurred in 7 of 100 patients in the medical intensive care unit who were intubated for more than 12 hours. Unilateral vocal fold immobility was associated with inpatient hypotension and preadmission vascul…

Incidence and Outcomes of Acute Laryngeal Injury After Prolonged Mechanical Ventilation* Open

Justin R. Shinn, Kyle S. Kimura, Benjamin R. Campbell, Anne S. Lowery, Christopher T. Wootten , et al. · 2019

Objectives: Upper airway injury is a recognized complication of prolonged endotracheal intubation, yet little attention has been paid to the consequences of laryngeal injury and functional impact. The purpose of our study was to prospectiv…

Early medical therapy for acute laryngeal injury (ALgI) following endotracheal intubation: a protocol for a prospective single-centre randomised controlled trial Open

Anne S. Lowery, Kyle S. Kimura, Justin R. Shinn, Chevis N. Shannon, Alexander Gelbard · 2019

Introduction Respiratory failure requiring endotracheal intubation accounts for a significant proportion of intensive care unit (ICU) admissions. Little attention has been paid to the laryngeal consequences of endotracheal intubation. Acut…

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