Kyle Staller
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View article: Low Rates of Physiologic Testing and Prescription Drug Use for <scp>FC</scp> and <scp>IBS</scp> ‐C in Patients With Inflammatory Bowel Disease
Low Rates of Physiologic Testing and Prescription Drug Use for <span>FC</span> and <span>IBS</span> ‐C in Patients With Inflammatory Bowel Disease Open
Purpose While inflammatory bowel diseases (IBD) are traditionally characterized as a diarrheal illness, comorbid constipation is under‐recognized. We evaluated the management patterns of IBD patients with comorbid constipation. Methods We …
View article: Exploring Transdiagnostic Eating Disorder Symptoms and Disorder of Gut‐Brain Interaction Symptoms in Individuals With Connective Tissue Disorders
Exploring Transdiagnostic Eating Disorder Symptoms and Disorder of Gut‐Brain Interaction Symptoms in Individuals With Connective Tissue Disorders Open
Objective Individuals with connective tissue disorders (CTDs) commonly experience gastrointestinal (GI) symptoms resulting from disorders of gut‐brain interaction (DGBI) and may attempt to manage GI distress with dietary restriction. Among…
View article: Food Insecurity and Gastrointestinal Health: Examining Links Between Food Security, Constipation, and Diarrhea in the National Health and Nutrition Examination Survey
Food Insecurity and Gastrointestinal Health: Examining Links Between Food Security, Constipation, and Diarrhea in the National Health and Nutrition Examination Survey Open
Purpose Food insecurity impacts health in a multifactorial fashion, but the relationship with bowel habits is poorly understood. We aimed to examine the association between food insecurity status and bowel habits in a large cohort of U.S. …
View article: Impact of Short Duration FODMAP Restriction on Breath Gases and Gastrointestinal Symptoms
Impact of Short Duration FODMAP Restriction on Breath Gases and Gastrointestinal Symptoms Open
INTRODUCTION: Irritable bowel syndrome symptoms are thought to relate in part to the accumulation of luminal gases after ingestion of fermentable carbohydrates (i.e., fermentable oligosaccharides, disaccharides and monosaccharides, and pol…
View article: Single-cell transcriptomic characterization of microscopic colitis
Single-cell transcriptomic characterization of microscopic colitis Open
Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine and a common cause of chronic diarrhea in older adults. Here, we use single-cell RNA sequencing analysis of colonic mucosal tissue to build a cellular and mo…
View article: Relationship Between Hemoglobin A1c and Fecal Incontinence in a Nationwide Cohort Study
Relationship Between Hemoglobin A1c and Fecal Incontinence in a Nationwide Cohort Study Open
Introduction Gastrointestinal manifestations of diabetes include a variety of symptoms, including fecal incontinence (FI). We investigated the relationship between hemoglobin A1c and FI among US adults in a large, population‐based survey. …
View article: Bilingual Perspectives of Functional Dyspepsia Management in People From Underserved Areas
Bilingual Perspectives of Functional Dyspepsia Management in People From Underserved Areas Open
INTRODUCTION: Disorders of gut-brain interaction, such as functional dyspepsia (FD), are prevalent and challenging conditions. In other gastrointestinal (GI) disorders, individuals from underserved areas (UAs) have difficulty accessing car…
View article: Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies
Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies Open
Genetic sharing of migraine and non-immune-related GI disorders was extensive yet distinct across GI disorders that have overlapping symptoms, with enrichment signals that imply neurologic mechanisms. Causal effects of some GI conditions o…
View article: Composition and Function of the Gut Microbiome in Microscopic Colitis
Composition and Function of the Gut Microbiome in Microscopic Colitis Open
Background Microscopic colitis (MC) is a common cause of chronic diarrhea, predominantly among older adults. Emerging evidence suggests that perturbations of gut microbiome and metabolome may play an important role in MC pathogenesis. Obje…
View article: Metagenomics Analysis Reveals Unique Gut Microbiota Signature of Slow-Transit Constipation
Metagenomics Analysis Reveals Unique Gut Microbiota Signature of Slow-Transit Constipation Open
INTRODUCTION: Altered gut microbiota may play a role in slow-transit constipation (STC). We conducted a study of gut microbiota composition and functionality in STC using metagenomic analyses. METHODS: We assembled a clinical cohort of 24 …
View article: Editorial: Vibrating capsule for severe chronic idiopathic constipation—Severity lies in the eye of the beholder
Editorial: Vibrating capsule for severe chronic idiopathic constipation—Severity lies in the eye of the beholder Open
LINKED CONTENT This article is linked to Lembo et al paper. To view this article, visit https://doi.org/10.1111/apt.18198
View article: Maladaptive weight control and eating behaviours in female adolescents/young adults are associated with increased risk of irritable bowel syndrome in adulthood: Results from the Growing Up Today Study (GUTS)
Maladaptive weight control and eating behaviours in female adolescents/young adults are associated with increased risk of irritable bowel syndrome in adulthood: Results from the Growing Up Today Study (GUTS) Open
Summary Background Irritable bowel syndrome (IBS) is common among individuals with eating disorders. The relationship between these conditions is likely bidirectional. However, data on the risk of IBS among those with prior eating disorder…
View article: Pain is a cardinal symptom cutting across Rome <scp>IV</scp> anatomical categories in disorders of gut‐brain interaction: A network‐based approach
Pain is a cardinal symptom cutting across Rome <span>IV</span> anatomical categories in disorders of gut‐brain interaction: A network‐based approach Open
Introduction Disorders of gut‐brain interaction (DGBI) are symptom‐based disorders categorized by anatomic location but have high overlap and heterogeneity. Viewing DGBI symptoms on a spectrum (i.e. dimensionally) rather than categorically…
View article: The Development of Persistent Gastrointestinal Symptoms in Patients With Melanoma Who Have Had an Immune Checkpoint Inhibitor-Related Gastrointestinal Toxicity
The Development of Persistent Gastrointestinal Symptoms in Patients With Melanoma Who Have Had an Immune Checkpoint Inhibitor-Related Gastrointestinal Toxicity Open
INTRODUCTION: Immune-related adverse events (irAE) secondary to immune checkpoint inhibitors (ICI) have gastrointestinal (GI) manifestations, including gastritis, enteritis, and/or colitis. The long-term sequelae of ICI-associated GI toxic…
View article: Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With <scp>ARFID</scp>
Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With <span>ARFID</span> Open
Objective Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition‐related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the m…
View article: Real‐world outcomes for a digital prescription mobile application for adults with irritable bowel syndrome
Real‐world outcomes for a digital prescription mobile application for adults with irritable bowel syndrome Open
Background Mahana™ IBS is a Food and Drug Administration‐cleared prescription mobile application designed to deliver 3 months of gut‐directed cognitive behavioral therapy (CBT) to adults ≥22 years old with irritable bowel syndrome (IBS). W…
View article: An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission Open
Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells fro…
View article: Large-Caliber Empiric Esophageal Dilation Results in Sustained Improvement for Selected Patients With Nonobstructive Dysphagia
Large-Caliber Empiric Esophageal Dilation Results in Sustained Improvement for Selected Patients With Nonobstructive Dysphagia Open
INTRODUCTION: Empiric esophageal dilation (EED) remains a controversial practice for managing nonobstructive dysphagia (NOD) secondary to concerns about safety and efficacy. We examine symptom response, presence of tissue disruption, and a…
View article: Gastrointestinal diagnoses in patients with eating disorders: A retrospective cohort study 2010–2020
Gastrointestinal diagnoses in patients with eating disorders: A retrospective cohort study 2010–2020 Open
Background and Aims Gastrointestinal (GI) disorders are common in patients with eating disorders. However, the temporal relationship between GI and eating disorder symptoms has not been explored. We aimed to evaluate GI disorders among pat…
View article: Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation
Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation Open
Background Chronic constipation (CC) is defined by symptom criteria reflecting heterogenous physiology. However, many patients with CC have significant psychological comorbidities—an alternative definition using a biopsychosocial classific…
View article: Association Between Celiac Disease and Irritable Bowel Syndrome: A Nationwide Cohort Study
Association Between Celiac Disease and Irritable Bowel Syndrome: A Nationwide Cohort Study Open
In patients with CD, the risk of IBS is increased long before and after diagnosis. Clinicians should be aware of these long-term associations and their implications on patient management.
View article: Letter: Irritable bowel syndrome and antibiotics—Authors' reply
Letter: Irritable bowel syndrome and antibiotics—Authors' reply Open
LINKED CONTENT This article is linked to Staller et al papers. To view these articles, visit https://doi.org/10.1111/apt.17736 and https://doi.org/10.1111/apt.17837
View article: Efficacy and safety of prucalopride in patients with chronic idiopathic constipation stratified by age, body mass index, and renal function: a post hoc analysis of phase III and IV, randomized, placebo-controlled clinical studies
Efficacy and safety of prucalopride in patients with chronic idiopathic constipation stratified by age, body mass index, and renal function: a post hoc analysis of phase III and IV, randomized, placebo-controlled clinical studies Open
Background: Prucalopride (1 or 2 mg once daily) is approved for treating adults with chronic idiopathic constipation (CIC). Objectives: We determined the effect of age, body mass index (BMI), and renal function on the efficacy and safety o…