Kyle T. Bernstein
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View article: Host-specific microbiomes of blow flies: ecological drivers and implications for pathogen carriage
Host-specific microbiomes of blow flies: ecological drivers and implications for pathogen carriage Open
Blow flies ( Lucilia sericata and Phormia regina ) are necrophagous insects that interact with dense microbial reservoirs and are opportunistic vectors of human and animal pathogens. Despite constant exposure to diverse environmental micro…
View article: Modernizing Public Health Data Systems and Workforce Capacity: The Centers for Disease Control and Prevention’s Public Health Informatics Fellowship Program
Modernizing Public Health Data Systems and Workforce Capacity: The Centers for Disease Control and Prevention’s Public Health Informatics Fellowship Program Open
Context: The COVID-19 pandemic exposed governmental public health’s outdated information technology and insufficient data science and informatics workforce capacity. The Centers for Disease Control and Prevention’s Public Health Informatic…
View article: Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis
Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis Open
Background There is no licensed vaccine against gonorrhea, but Neisseria meningitidis serogroup B outer membrane vesicle–based vaccines, such as MenB-4C, may offer cross-protection against gonorrhea. This systematic review and meta-analysi…
View article: Changes in Partner-Seeking and Sexual Behavior Among US Adults During the First 2 Years of the COVID-19 Pandemic
Changes in Partner-Seeking and Sexual Behavior Among US Adults During the First 2 Years of the COVID-19 Pandemic Open
Background The COVID-19 pandemic may have influenced partner-seeking and sexual behaviors of adults. Methods We examined cross-sectional survey data collected at the end of the first year (n = 1161) and second year (n = 1233) of the COVID-…
View article: Expanding the Evidence Base for Improving Sexual Health Among Transgender Communities: The Importance of Rigorous Epidemiologic Studies
Expanding the Evidence Base for Improving Sexual Health Among Transgender Communities: The Importance of Rigorous Epidemiologic Studies Open
The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.Though approximately 1.3 million adults identify as transgender in United Stat…
View article: Evaluation of Public Health Contact Tracing for Mpox Among Gay, Bisexual, and Other Men Who Have Sex With Men—10 US Jurisdictions, May 17–July 31, 2022
Evaluation of Public Health Contact Tracing for Mpox Among Gay, Bisexual, and Other Men Who Have Sex With Men—10 US Jurisdictions, May 17–July 31, 2022 Open
Objectives. To examine the potential impact of contact tracing to identify contacts and prevent mpox transmission among gay, bisexual, and other men who have sex with men (MSM) as the outbreak expanded. Methods. We assessed contact tracing…
View article: Kiss Around and Find Out: Kissing as a Risk Factor for Pharyngeal Gonorrhea
Kiss Around and Find Out: Kissing as a Risk Factor for Pharyngeal Gonorrhea Open
Chesson, Harrell W. PhD; Bernstein, Kyle T. PhD; Barbee, Lindley A. MD, MPH Author Information
View article: Chemsex Drug Use among a National Sample of Sexually Active Men who have Sex with Men, – American Men’s Internet Survey, 2017–2020
Chemsex Drug Use among a National Sample of Sexually Active Men who have Sex with Men, – American Men’s Internet Survey, 2017–2020 Open
Background: Chemsex is the intentional use of drugs to enhance sexual activity. Chemsex drug use among men who have sex with men (MSM) is associated with sexual behaviors that increase sexually transmitted infection (STI) risks and …
View article: Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea
Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea Open
Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiven…
View article: 1520. Mind the Clap: Reported Disseminated Gonococcal Infections in the United States, 2020–2022
1520. Mind the Clap: Reported Disseminated Gonococcal Infections in the United States, 2020–2022 Open
Background Disseminated gonococcal infections (DGI) are estimated to occur in 0.5% to 3% of untreated Neisseria gonorrhoeae (GC) infections; however, surveillance and population-based studies to estimate DGI burden and describe recent DGI …
View article: Changes in Sexual Behavior Over the COVID-19 Pandemic Among a Community-Based Cohort of Men Who Have Sex With Men in Columbus, Ohio
Changes in Sexual Behavior Over the COVID-19 Pandemic Among a Community-Based Cohort of Men Who Have Sex With Men in Columbus, Ohio Open
Background The purpose was to assess COVID-19 beliefs and attitudes and examine COVID-19–related changes in sexual behavior of men who have sex with men during 3 time periods: April–July 2020 (T1), August–December 2020 (T2), January–May 20…
View article: The Role of HIV Partner Services in the Modern Biomedical HIV Prevention Era: A Network Modeling Study
The Role of HIV Partner Services in the Modern Biomedical HIV Prevention Era: A Network Modeling Study Open
Background HIV partner services can accelerate the use of antiretroviral-based HIV prevention tools (antiretroviral therapy [ART] and preexposure prophylaxis [PrEP]), but its population impact on long-term HIV incidence reduction is challe…
View article: The Role of HIV Partner Services in the Modern Biomedical HIV Prevention Era: A Network Modeling Study
The Role of HIV Partner Services in the Modern Biomedical HIV Prevention Era: A Network Modeling Study Open
Background HIV partner services can accelerate the use of antiretroviral-based HIV prevention tools (ART and PrEP), but its population impact on long-term HIV incidence reduction is challenging to quantify with traditional PS metrics of pa…
View article: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study
Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study Open
View article: Variation in Patterns of Racial and Ethnic Disparities in Primary and Secondary Syphilis Diagnosis Rates Among Heterosexually Active Women by Region and Age Group in the United States
Variation in Patterns of Racial and Ethnic Disparities in Primary and Secondary Syphilis Diagnosis Rates Among Heterosexually Active Women by Region and Age Group in the United States Open
Background Syphilis rates have increased substantially over the past decade. Women are an important population because of negative sequalae and adverse maternal outcomes including congenital syphilis. We assessed whether racial and ethnic …
View article: Partner Seeking and Sexual Behavior in the United States During the COVID-19 Pandemic, March 2020 to March 2021
Partner Seeking and Sexual Behavior in the United States During the COVID-19 Pandemic, March 2020 to March 2021 Open
We examined partner seeking and sexual behaviors among a representative sample of US adults (n = 1161) during the first year of the COVID-19 pandemic. Approximately 10% of survey respondents sought a new partner, with age and sexual identi…
View article: Effectiveness of Syphilis Partner Notification After Adjusting for Treatment Dates, 7 Jurisdictions
Effectiveness of Syphilis Partner Notification After Adjusting for Treatment Dates, 7 Jurisdictions Open
Background Disease intervention specialists (DIS) prevent syphilis by ensuring treatment for patients' sex partners through partner notification (PN). Different interpretations of how to measure partners treated due to DIS efforts complica…
View article: O20.3 Quantitative Chlamydia trachomatis Pgp3 seropositivity and reproductive sequelae among women, National Health and Nutrition Examination Survey, United States, 2013–2016
O20.3 Quantitative Chlamydia trachomatis Pgp3 seropositivity and reproductive sequelae among women, National Health and Nutrition Examination Survey, United States, 2013–2016 Open
Background Chlamydia trachomatis infection causes reproductive sequelae of pelvic inflammatory disease (PID) and tubal infertility. Previous studies have demonstrated a relationship between levels of chlamydia antibody and these sequelae. …
View article: P139 A Phylogenomic Survey of Disseminated Gonococcal Infection Isolates in the United States (2019–2020)
P139 A Phylogenomic Survey of Disseminated Gonococcal Infection Isolates in the United States (2019–2020) Open
Background In December 2019, Centers for Disease Control and Prevention (CDC) released a Dear Colleagues Letter describing best practices for investigation of Disseminated Gonococcal Infection (DGI) cases which stressed the importance of c…
View article: High Plasmid Gene Protein 3 (Pgp3) <i>Chlamydia trachomatis</i> Seropositivity, Pelvic Inflammatory Disease, and Infertility Among Women, National Health and Nutrition Examination Survey, United States, 2013–2016
High Plasmid Gene Protein 3 (Pgp3) <i>Chlamydia trachomatis</i> Seropositivity, Pelvic Inflammatory Disease, and Infertility Among Women, National Health and Nutrition Examination Survey, United States, 2013–2016 Open
Background Chlamydia trachomatis causes pelvic inflammatory disease (PID) and tubal infertility. Plasmid gene protein 3 antibody (Pgp3Ab) detects prior chlamydial infections. We evaluated for an association of high chlamydial seropositivit…
View article: Tubal Factor Infertility, In Vitro Fertilization, and Racial Disparities: A Retrospective Cohort in Two US Clinics
Tubal Factor Infertility, In Vitro Fertilization, and Racial Disparities: A Retrospective Cohort in Two US Clinics Open
Background Nearly 14% of US women report any lifetime infertility which is associated with health care costs and psychosocial consequences. Tubal factor infertility (TFI) often occurs as a result of sexually transmitted diseases and subseq…
View article: Chlamydial Pgp3 Seropositivity and Population-Attributable Fraction Among Women With Tubal Factor Infertility
Chlamydial Pgp3 Seropositivity and Population-Attributable Fraction Among Women With Tubal Factor Infertility Open
Background Chlamydial infection is associated with tubal factor infertility (TFI); however, assessment of prior chlamydial infection and TFI is imperfect. We previously evaluated a combination of serological assays for association with TFI…
View article: Factors Associated With Online Sex Partners Among Gay, Bisexual and Other Men Who Have Sex With Men: Results From a National Survey
Factors Associated With Online Sex Partners Among Gay, Bisexual and Other Men Who Have Sex With Men: Results From a National Survey Open
Background Associations between online sex seeking and increased risk for sexually transmitted infections (STIs) and human immunodeficiency virus (HIV) among men who have sex with men (MSM) typically rely on convenience samples. We examine…
View article: Risk of HIV Acquisition Among Men Who Have Sex With Men Infected With Bacterial Sexually Transmitted Infections: A Systematic Review and Meta-Analysis
Risk of HIV Acquisition Among Men Who Have Sex With Men Infected With Bacterial Sexually Transmitted Infections: A Systematic Review and Meta-Analysis Open
Background Men who have sex with men (MSM) who have bacterial sexually transmitted infections (STIs) are at increased risk for HIV infection. We enhanced and updated past summary risk estimates. Methods We systematically reviewed (PROSPERO…
View article: A Review of the Challenges and Complexities in the Diagnosis, Etiology, Epidemiology, and Pathogenesis of Pelvic Inflammatory Disease
A Review of the Challenges and Complexities in the Diagnosis, Etiology, Epidemiology, and Pathogenesis of Pelvic Inflammatory Disease Open
Pelvic inflammatory disease (PID) is a syndrome that causes substantial morbidity, including chronic pelvic pain, to women globally. While limited data are available from low- and middle-income countries, national databases from the United…
View article: Sexually Transmitted Infection Testing Among Transgender Women Living with Human Immunodeficiency Virus in the United States: Medical Monitoring Project, 2015–2019
Sexually Transmitted Infection Testing Among Transgender Women Living with Human Immunodeficiency Virus in the United States: Medical Monitoring Project, 2015–2019 Open
National guidelines recommend annual sexually transmitted infection testing for sexually active people living with human immunodeficiency virus, including transgender women. Using data from the US Medical Monitoring Project during 2015–201…
View article: Genital Mycoplasma, Shigellosis, Zika, Pubic Lice, and Other Sexually Transmitted Infections: Neither Gone Nor Forgotten
Genital Mycoplasma, Shigellosis, Zika, Pubic Lice, and Other Sexually Transmitted Infections: Neither Gone Nor Forgotten Open
Most estimates of the combined burden and cost of sexually transmitted infections (STIs) in the United States have focused on 8 common STIs with established national surveillance strategies (chlamydia, gonorrhea, syphilis, trichomoniasis, …
View article: Sexually Transmitted Disease Core Theory: Roles of Person, Place, and Time
Sexually Transmitted Disease Core Theory: Roles of Person, Place, and Time Open
The authors’ purpose was to expand sexually transmitted disease core theory by examining the roles of person, place, and time in differentiating geographic core areas from outbreak areas. The authors mapped yearly census-tract-level syphil…
View article: Pre-exposure Prophylaxis Use and Detected Sexually Transmitted Infections Among Men Who Have Sex With Men in the United States—National HIV Behavioral Surveillance, 5 US Cities, 2017
Pre-exposure Prophylaxis Use and Detected Sexually Transmitted Infections Among Men Who Have Sex With Men in the United States—National HIV Behavioral Surveillance, 5 US Cities, 2017 Open
Background: Men who have sex with men (MSM) using HIV pre-exposure prophylaxis (PrEP) may be at high risk for bacterial sexually transmitted infections (STIs). We examined the prevalence of extragenital gonorrhea and chlamydia by PrEP stat…
View article: COVID-19 Contact Tracing in Two Counties — North Carolina, June–July 2020
COVID-19 Contact Tracing in Two Counties — North Carolina, June–July 2020 Open
Contact tracing is a strategy implemented to minimize the spread of communicable diseases (1,2). Prompt contact tracing, testing, and self-quarantine can reduce the transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019…