Kyle V. Cicalese
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View article: Quality of life in chordoma survivors: results from the Chordoma Foundation Survivorship Survey
Quality of life in chordoma survivors: results from the Chordoma Foundation Survivorship Survey Open
OBJECTIVE Chordomas are rare malignant bone tumors whose location in the skull base or spine, invasive surgical treatment, and accompanying adjuvant radiotherapy may all lead patients to experience poor quality of life (QOL). Limited resea…
View article: Reducing Gadolinium Exposure in Patients Undergoing Monitoring for Meningiomas
Reducing Gadolinium Exposure in Patients Undergoing Monitoring for Meningiomas Open
Background Due to the non-malignant and slow-growing nature of many meningiomas, surveillance with serial magnetic resonance imaging (MRI) serves as an acceptable management plan. However, repeated imaging with gold-standard contrast-based…
View article: Quality of Life in Chordoma Co-Survivors: Results from the Chordoma Foundation Survivorship Survey
Quality of Life in Chordoma Co-Survivors: Results from the Chordoma Foundation Survivorship Survey Open
Our findings suggest that younger co-survivors are at high risk for adverse emotional QOL outcomes. In addition, more than one third of co-survivors did not know about resources to address their QOL issues. Our study may help guide organiz…
View article: Social determinants of health and the prediction of 90-day mortality among brain tumor patients
Social determinants of health and the prediction of 90-day mortality among brain tumor patients Open
OBJECTIVE Within the neurosurgical oncology literature, the effect of structural and socioeconomic factors on postoperative outcomes remains unclear. In this study, the authors quantified the effects of social determinant of health (SDOH) …
View article: Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment
Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment Open
CD47 is a ubiquitously expressed cell surface glycoprotein that functions as a signaling receptor for thrombospondin-1 and as the counter-receptor for signal regulatory protein-α (SIRPα). Engaging SIRPα on macrophages inhibits phagocytosis…
View article: The state of the translational chaperone ICD-1 during apoptosis in Caenorhabditis elegans
The state of the translational chaperone ICD-1 during apoptosis in Caenorhabditis elegans Open
The unfolded protein response (UPR) is a signal transduction cascade that mitigates low levels of misfolded protein stress in the endoplasmic reticulum (ER) in an effort to save the affected cell, while prolonged and/or acute ER stress lea…