Kyle Ware
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View article: An Overview of Chronic Spontaneous Urticaria: Diagnosis, Management, and Treatment
An Overview of Chronic Spontaneous Urticaria: Diagnosis, Management, and Treatment Open
Chronic spontaneous urticaria (CSU) is a complex mast cell-driven disorder characterized by recurrent pruritic wheals and/or angioedema lasting over 6 weeks. This condition affects women more frequently than men, particularly between the a…
View article: Hypertension and the Kidney: Reduced Kidney Mass Is Bad for Both Normotensive and Hypertensive Rats
Hypertension and the Kidney: Reduced Kidney Mass Is Bad for Both Normotensive and Hypertensive Rats Open
BACKGROUND Hypertension is a leading cause of chronic kidney disease worldwide. Early studies demonstrated the short-term effects of hypertension on kidney function and morphology in ablative nephropathy. The aim of this study was to inves…
View article: The Severity of Intracranial Hemorrhages Measured by Free Hemoglobin in the Brain Depends on the Anticoagulant Class: Experimental Data
The Severity of Intracranial Hemorrhages Measured by Free Hemoglobin in the Brain Depends on the Anticoagulant Class: Experimental Data Open
Background and Purpose. Anticoagulant therapy is broadly used to prevent thromboembolic events. Intracranial hemorrhages are serious complications of anticoagulation, especially with warfarin. Direct oral anticoagulants reduce but do not e…
View article: The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures
The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures Open
Superwarfarins were developed following the emergence of warfarin resistance in rodents. Compared to warfarin, superwarfarins have much longer half‐lives and stronger affinity to vitamin K epoxide reductase and therefore can cause death in…
View article: Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning
Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning Open
Introduction: Brodifacoum (BDF) is a superwarfarin that is used primarily as a rodenticide. There have been increasing numbers of reports of human cases of accidental or intentional BDF ingestion with high mortality rate. Its broad availab…