Kylie J. Schache
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View article: Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau Open
View article: Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies
Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies Open
Therapeutics that rescue folding, trafficking, and function of disease-causing missense mutants are sought for a host of human diseases, but efforts to leverage model systems to test emerging strategies have met with limited success. Such …
View article: Species-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease
Species-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease Open
The folding and trafficking of transmembrane glycoproteins are essential for cellular homeostasis and are compromised in many diseases. In Niemann-Pick type C disease, a lysosomal disorder characterized by impaired intracellular cholestero…
View article: Going Virtual: Successes and Shortcomings of a Synchronous STEM Outreach Event
Going Virtual: Successes and Shortcomings of a Synchronous STEM Outreach Event Open
Gender disparities in STEM fields emerge starting in the fourth grade, when girls are less likely than boys to express interest in STEM fields. Outreach events targeted to girls during this crucial developmental period can foster a sense o…
View article: Disrupting the Balance of Protein Quality Control Protein UBQLN2 Accelerates Tau Proteinopathy
Disrupting the Balance of Protein Quality Control Protein UBQLN2 Accelerates Tau Proteinopathy Open
Tau protein accumulation drives toxicity in several neurodegenerative disorders. To better understand the pathways regulating tau homeostasis in disease, we investigated the role of ubiquilins (UBQLNs)—a class of proteins linked to ubiquit…
View article: Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8 Open