Kylie S. Foo
YOU?
Author Swipe
View article: Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors Open
Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft crosstalk remains…
View article: Primate heart regeneration<i>via</i>migration and fibroblast repulsion by human heart progenitors
Primate heart regeneration<i>via</i>migration and fibroblast repulsion by human heart progenitors Open
SUMMARY Human heart regeneration is one of the most critical unmet clinical needs at a global level 1 . Muscular regeneration is hampered both by the limited renewing capacity of adult cardiomyocytes 2-4 and the onset of cardiac fibrosis 5…
Genome-wide CRISPR screen identifies <i>ZIC2</i> as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors Open
Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators for cardiac progeni…
View article: Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction Open
The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the generation of an en…