Kyoji Horie
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View article: Inhibition of N-myristoyltransferase in pluripotent stem cells promotes the naive state in mice and elicits trophectoderm and primitive endoderm markers in humans
Inhibition of N-myristoyltransferase in pluripotent stem cells promotes the naive state in mice and elicits trophectoderm and primitive endoderm markers in humans Open
Naive and primed states represent distinct phases of pluripotency during early embryonic development, both of which can be captured and interconverted in vitro. To understand pluripotency regulation, we performed a recessive genetic screen…
View article: A newly identified gene Ahed plays essential roles in murine haematopoiesis
A newly identified gene Ahed plays essential roles in murine haematopoiesis Open
The development of haematopoiesis involves the coordinated action of numerous genes, some of which are implicated in haematological malignancies. However, the biological function of many genes remains elusive and unknown functional genes a…
View article: ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels Open
BACKGROUND: Most organs are maintained lifelong by resident stem/progenitor cells. During development and regeneration, lineage-specific stem/progenitor cells can contribute to the growth or maintenance of different organs, whereas fully d…
View article: Issue Information
Issue Information Open
Accumulation of residual glycogen under glycophagy deficiency • S1PL gene therapy augments endogenous antifibrotic signaling in lung injury • The genetic and clinicopathological features of cholangiolocarcinoma • ScRNA-seq for stromal Lkb1…
View article: Mutation of the SWI/SNF complex component <i>Smarce1</i> decreases nucleosome stability in embryonic stem cells and impairs differentiation
Mutation of the SWI/SNF complex component <i>Smarce1</i> decreases nucleosome stability in embryonic stem cells and impairs differentiation Open
The SWI/SNF chromatin remodeling complex consists of more than ten component proteins that form a large protein complex of >1 MDa. The catalytic proteins Smarca4 or Smarca2 work in concert with the component proteins to form a chromatin…
View article: A newly identified gene Ahed plays essential roles in haematopoiesis through RNA splicing
A newly identified gene Ahed plays essential roles in haematopoiesis through RNA splicing Open
The development of haematopoiesis is regulated by coordinated actions of multiple genes. Mutations in some genes are intimately involved in the occurrence of haematological cancers. Here, we report a previously undefined functional gene in…
View article: S254: A NEW GENE AHED PLAYS ESSENTIAL ROLES IN HEMATOPOIESIS THROUGH RNA-SPLICING
S254: A NEW GENE AHED PLAYS ESSENTIAL ROLES IN HEMATOPOIESIS THROUGH RNA-SPLICING Open
Background: The development of hematopoiesis in mammals is regulated by coordinated actions of multiple genes. Mutations in some genes are intimately involved in the occurrence of hematological cancers. Given that responsible mutations are…
View article: Long-read sequence analysis of MMEJ-mediated CRISPR genome editing reveals complex on-target vector insertions that may escape standard PCR-based quality control
Long-read sequence analysis of MMEJ-mediated CRISPR genome editing reveals complex on-target vector insertions that may escape standard PCR-based quality control Open
CRISPR genome editing is a powerful tool for elucidating biological functions. To modify the genome as intended, it is essential to understand the various modes of recombination that can occur. In this study, we report unexpected complex v…
View article: Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans
Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans Open
Most circulating endothelial cells are apoptotic, but rare circulating endothelial colony-forming cells (C-ECFCs), also known as blood outgrowth endothelial cells, with proliferative and vasculogenic activity can be cultured; however, the …
View article: Comparison of CRISPR-Cas9-mediated megabase-scale genome deletion methods in mouse embryonic stem cells
Comparison of CRISPR-Cas9-mediated megabase-scale genome deletion methods in mouse embryonic stem cells Open
The genome contains large functional units ranging in size from hundreds of kilobases to megabases, such as gene clusters and topologically associating domains. To analyse these large functional units, the technique of deleting the entire …
View article: Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human
Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human Open
Summary Most circulating endothelial cells are apoptotic, but rare circulating endothelial colony forming cells (C-ECFCs) with proliferative and vasculogenic activity can be cultured; the origin and naïve function of these C-ECFCs remains …
View article: Disruption of Smarce1, a component of the SWI/SNF chromatin remodeling complex, decreases nucleosome stability in mouse embryonic stem cells and impairs differentiation
Disruption of Smarce1, a component of the SWI/SNF chromatin remodeling complex, decreases nucleosome stability in mouse embryonic stem cells and impairs differentiation Open
The SWI/SNF chromatin remodeling complex consists of more than 10 component proteins that form a large protein complex of > 1 MDa. The catalytic proteins Smarca4 or Smarca2 work in concert with the component proteins to form a chromatin pl…
View article: Expansions for ground state in the transverse field Edwards-Anderson model
Expansions for ground state in the transverse field Edwards-Anderson model Open
It is proven that the ground state in the transverse field Edwards-Anderson model is unique for weak transverse fields or weak exchange interactions in a $d$-dimensional finite cubic lattice. Recently proven uniqueness property of the grou…
View article: Collection of homozygous mutant mouse embryonic stem cells arising from autodiploidization during haploid gene trap mutagenesis
Collection of homozygous mutant mouse embryonic stem cells arising from autodiploidization during haploid gene trap mutagenesis Open
Haploid mouse embryonic stem cells (ESCs), in which a single hit mutation is sufficient to produce loss-of-function phenotypes, have provided a powerful tool for forward genetic screening. This strategy, however, can be hampered by undesir…