Explanipedia

The AHR–NRF2–JDP2 gene battery: Ligand–induced AHR transcriptional activation Open

Kenly Wuputra, Wen-Hung Hsu, Chia‐Chen Ku, Ya-Han Yang, Kung‐Kai Kuo , et al. · 2025

Aryl hydrocarbon receptor (AHR) and nuclear factor-erythroid 2-related factor 2 (NRF2) can regulate a series of genes encoding the detoxifying phase I and II enzymes, via a signaling crosstalk known as the "AHR-NRF2 gene battery". The chro…

Nuclear reorganization by NPM1-mediated phase separation triggered by adenovirus core protein VII Open

Michelle Jane Genoveso, Mitsuru Okuwaki, Kohsuke Kato, Kyosuke Nagata, Atsushi Kawaguchi · 2024

Recent evidence has revealed that the reorganization of nuclear domains is largely mediated by liquid-liquid phase separation (LLPS). During viral infection, numerous nuclear domains undergo significant changes through LLPS for and against…

A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes Open

Hiroaki Tabara, Shohei Mitani, Megumi Mochizuki, Yuji Kohara, Kyosuke Nagata · 2023

During meiosis, chromosomes with homologous partners undergo synaptonemal complex (SC)‐mediated pairing, while the remaining unpaired chromosomes are heterochromatinized through unpaired silencing. Mechanisms underlying homolog recognition…

Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA Open

Bálint Hajdu, Éva Hunyadi‐Gulyás, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata , et al. · 2023

Zinc finger proteins specifically recognize DNA sequences and, therefore, play a crucial role in living organisms. In this study the Zn(II)-, and DNA-binding of 1MEY#, an artificial zinc finger protein consisting of three finger units was …

ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation Open

Takahiro Kuroki, Tomohisa Hatta, Tohru Natsume, Nobuaki Sakai, Akira Yagi , et al. · 2022

The endocytic transport of the influenza viral genome triggers the clustering of viral membrane proteins at the plasma membrane to form the viral budozone. However, host factors that promote viral budozone formation in concert with viral g…

Human sorting nexin 2 protein interacts with Influenza A virus PA protein and has a negative regulatory effect on the virus replication Open

Tuğba Koçmar, Elif Çağlayan, Erkan Rayaman, Kyosuke Nagata, Kadir Turan · 2021

Template activating factor-I epigenetically regulates the TERT transcription in human cancer cells Open

Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata · 2021

Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes Open

SangJoon Lee, Akari Ishitsuka, Takahiro Kuroki, Yu-Hsien Lin, Akira Shibuya , et al. · 2021

Asthma is a chronic inflammatory disease of the airways associated with excess production of Th2 cytokines and lung eosinophil accumulation. This inflammatory response persists in spite of steroid administration that blocks autocrine/parac…

SET‐NUP214 and MLL cooperatively regulate the promoter activity of the <i>HoxA10</i> gene Open

Sadık Çiğdem, Shoko Saito, Daiki Nishikata, Kyosuke Nagata, Mitsuru Okuwaki · 2021

SET‐Nup214 is a recurrent fusion gene that is mainly observed in T‐cell acute lymphoblastic leukemia (T‐ALL). Dysregulation of homeobox ( Hox ) genes is frequently observed in patients with leukemia. Consistent with this, HoxA genes are up…

Human Sorting Nexin 2 Protein Interacts With Influenza A Virus PA Protein and Has a Negative Regulatory Effect on the Virus Replication Open

Tuğba Koçmar, Elif Caglayan, Erkan Rayaman, Kyosuke Nagata, Kadir Turan · 2021

Replication of the influenza A viruses occurs in the cells through the viral RdRP consisting of PB1, PB2, and PA. Several cellular proteins are involved in these processes. To identify potential host interacting proteins to the viral PA, w…

SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres Open

Yuichiro Asai, Rieko Matsumura, Yurina Hasumi, Hiroaki Susumu, Kyosuke Nagata , et al. · 2020

During mitosis, spatiotemporal regulation of phosphorylation at the kinetochore is essential for accurate chromosome alignment and proper chromosome segregation. Aurora B kinase phosphorylates kinetochore substrates to correct improper kin…

Author Correction: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation Open

Chia‐Chen Ku, Kenly Wuputra, Kohsuke Kato, Wen‐Hsin Lin, Jia-Bin Pan , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation Open

Chia‐Chen Ku, Kenly Wuputra, Kohsuke Kato, Wen‐Hsin Lin, Jia-Bin Pan , et al. · 2020

Interaction of influenza A virus NS2/NEP protein with the amino-terminal part of Nup214 Open

Burçak Şenbaş Akyazi, Ayşegül Pirinçal, Atsushi Kawaguchi, Kyosuke Nagata, Kadir Turan · 2020

Influenza A viruses have a single-stranded RNA genome consisting of 8 segments. Each RNA segment associates with the nucleoprotein (NP) and viral RNA polymerase to and from a viral ribonucleoprotein (vRNP) particle. The viral mRNA synthesi…

Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming Open

Linh Bui, Ken Nishimura, Gonzalo Seminario Mondejar, Arun Kumar, Shiho Aizawa , et al. · 2019

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) is accompanied by dramatic changes in epigenetic programs, including silencing of endogenous and exogenous retroviruses. Here, we utilized replication-defective and pers…

Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere Open

Yuichiro Asai, Koh Fukuchi, Yuji Tanno, Saki Koitabashi-Kiyozuka, Tatsuyuki Kiyozuka , et al. · 2019

The accurate regulation of phosphorylation at the kinetochore is essential for establishing chromosome bi-orientation. Phosphorylation of kinetochore proteins by the Aurora B kinase destabilizes improper kinetochore–microtubule attachments…

Involvement of CTCF in transcription regulation of EGR1 at early G1 phase as an architecture factor Open

Takeshi Sekiya, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata · 2019

Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes Open

Takahiro Kuroki, Suguru Osari, Kyosuke Nagata, Atsushi Kawaguchi · 2018

Autophagy is an essential process for cellular metabolism and homeostasis, but also functions as one of innate immune responses against pathogen infection. However, in contrast to cellular metabolism and homeostasis pathways, less is known…

Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity Open

Takahiro Kuroki, SangJoon Lee, Mikako Hirohama, Tomohiro Taku, Michiko Kumakura , et al. · 2018

Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influen…

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner Open

SangJoon Lee, Mikako Hirohama, Masayuki Noguchi, Kyosuke Nagata, Atsushi Kawaguchi · 2018

Respiratory epithelial cell death by influenza virus infection is responsible for the induction of inflammatory responses, but the exact cell death mechanism is not understood. Here we showed that influenza virus infection induces apoptosi…

Current state of therapeutic development for rare cancers in Japan, and proposals for improvement Open

Akira Kawai, Toshio Goto, Tatsuhiro Shibata, Kenzaburo Tani, Shuki Mizutani , et al. · 2018

This article discusses current obstacles to the rapid development of safe and effective treatments for rare cancers, and considers measures required to overcome these challenges. In order to develop novel clinical options for rare cancers,…

Regulatory Science on AI-based Medical Devices and Systems Open

Kiyoyuki Chinzei, Akinobu Shimizu, Kensaku Mori, Kanako Harada, Hideaki Takeda , et al. · 2018

AI-based medical and healthcare devices and systems have unique characteristics including 1) plasticity causing changes in system performance through learning, and need of creating new concepts about the timing of learning and assignment o…

Nickel(<span>ii</span>)-promoted specific hydrolysis of zinc finger proteins Open

Agnieszka Belczyk-Ciesielska, Brigitta Csipak, Bálint Hajdu, Aleksandra Sparavier, Masamitsu N. Asaka , et al. · 2018

The (S/T)XH sequence in Cys₂His₂zinc fingers can be hydrolytically cleaved by Ni(ii) ions. This reaction can be applied for purification, inhibition or activation of designed zinc finger fusion proteins.

Selective regulation of type II interferon‐inducible genes by NPM1/nucleophosmin Open

Mayumi Abé, Jianhuang Lin, Kyosuke Nagata, Mitsuru Okuwaki · 2017

Nucleophosmin (NPM1) is a multifunctional nucleolar protein. Here, we analyze the role of NPM1 in gene expression using our previous microarray data and find a relationship between NPM1 and interferon (IFN)‐γ‐inducible genes. We show that …

Analysis by metadynamics simulation of binding pathway of influenza virus M2 channel blockers Open

Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa · 2017

M2 protein of influenza A virus is a proton channel spanning the viral envelope. Activity of this proton channel is required for uncoating of viral particles and equilibrating the pH across the trans Golgi apparatus, which prevents conform…

Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones Open

Takeshi Sekiya, Yifan Hu, Kohsuke Kato, Mitsuru Okuwaki, Atsushi Kawaguchi , et al. · 2017

Chemical Approach to Biological Safety: Molecular‐Level Control of an Integrated Zinc Finger Nuclease Open

Eszter Németh, Masamitsu N. Asaka, Kohsuke Kato, Zita Fábián, Chris Oostenbrink , et al. · 2017

Application of artificial nucleases (ANs) in genome editing is still hindered by their cytotoxicity related to off‐target cleavages. This problem can be targeted by regulation of the nuclease domain. Here, we provide an experimental survey…

Cellular splicing factor UAP56 stimulates trimeric NP formation for assembly of functional influenza viral ribonucleoprotein complexes Open

Yifan Hu, Vishal Gor, Kazuya Morikawa, Kyosuke Nagata, Atsushi Kawaguchi · 2017

The influenza virus RNA genome exists as a ribonucleoprotein (RNP) complex by interacting with NP, one of virus-encoded RNA binding proteins. It is proposed that trimeric NP is a functional form, but it is not clear how trimeric NP is form…

Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization Open

Shuhei Ueshima, Kyosuke Nagata, Mitsuru Okuwaki · 2017

Upstream binding factor (UBF) is a member of the high-mobility group (HMG) box protein family, characterized by multiple HMG boxes and a C-terminal acidic region (AR). UBF is an essential transcription factor for rRNA genes and mediates th…

Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells Open

Deng-Chyang Wu, Sophie S.W. Wang, Chung‐Jung Liu, Kenly Wuputra, Kohsuke Kato , et al. · 2017

Reprogramming of cancer cells into induced pluripotent stem cells (iPSCs) is a compelling idea for inhibiting oncogenesis, especially through modulation of homeobox proteins in this reprogramming process. We examined the role of various lo…

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