Kyriaki Barmpa
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View article: Vascularized midbrain assembloids show neuroinflammation and dopaminergic neuron vulnerability in Parkinson’s Disease
Vascularized midbrain assembloids show neuroinflammation and dopaminergic neuron vulnerability in Parkinson’s Disease Open
The use of micro-physiological systems has rapidly risen in the last years due to their translatability and complex cellular composition. Human midbrain-specific organoids contain neuroectoderm-derived cell types and are suitable for brain…
View article: MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss
MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss Open
View article: α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model Open
Understanding the progression of α‐synuclein pathology in neurodegenerative diseases such as Parkinson's disease (PD) is a longstanding challenge. Here, a novel midbrain–hindbrain‐assembloid model that recapitulates the spread of α‐synucle…
View article: Parkinson’s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss
Parkinson’s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss Open
The complex and heterogeneous nature of Parkinson's disease (PD) is still not fully understood. However, increasing evidence supports mitochondrial impairment as a major driver of neurodegeneration. Miro1, a mitochondrial GTPase encoded by…
View article: Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids
Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids Open
View article: Parkinson’s disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons<i>in vitro</i>and<i>in vivo</i>
Parkinson’s disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons<i>in vitro</i>and<i>in vivo</i> Open
The complex and heterogeneous nature of Parkinson’s disease (PD) is still not fully understood, however, increasing evidence supports mitochondrial impairments as a major driver of neurodegeneration in PD. Recently, the regulator of mitoch…
View article: Age-induced midbrain-striatum assembloids model early phenotypes of Parkinson’s disease
Age-induced midbrain-striatum assembloids model early phenotypes of Parkinson’s disease Open
Parkinson’s disease (PD), one of the most common aging-associated neurodegenerative disorders, is characterised by nigrostriatal pathway dysfunction, caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta …
View article: Age-induced midbrain-striatum assembloid models early phenotypes of Parkinson's disease
Age-induced midbrain-striatum assembloid models early phenotypes of Parkinson's disease Open
View article: Age-induced midbrain-striatum assembloid models early phenotypes of Parkinson's disease
Age-induced midbrain-striatum assembloid models early phenotypes of Parkinson's disease Open
View article: Generalising from conventional pipelines using deep learning in high-throughput screening workflows
Generalising from conventional pipelines using deep learning in high-throughput screening workflows Open
View article: Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality Open
The human brain is a complex, three‐dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human‐specific midbrain organoids. Human iPSC‐derived midbrain organoids consist of diffe…
View article: Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression
Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression Open
Human brain organoid models that recapitulate the physiology and complexity of the human brain have a great potential for in vitro disease modeling, in particular for neurodegenerative diseases, such as Parkinson disease. In the present st…
View article: Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality Open
The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids. Human iPSC-derived midbrain organoids consist of diffe…
View article: Generalising from Conventional Pipelines: A Case Study in Deep Learning-Based for High-Throughput Screening
Generalising from Conventional Pipelines: A Case Study in Deep Learning-Based for High-Throughput Screening Open
The study of complex diseases relies on large amounts of data to build models toward precision medicine. Such data acquisition is feasible in the context of high-throughput screening, in which the quality of the results relies on the accur…
View article: Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by <scp>2‐Hydroxypropyl‐β‐Cyclodextrin</scp> Treatment
Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by <span>2‐Hydroxypropyl‐β‐Cyclodextrin</span> Treatment Open
Background The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the phosphatase …
View article: Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment
Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment Open
The etiology of Parkinson’s disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the PTEN-induced putative k…