Kyu Yun Jang
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View article: Impact of Cell-of-Origin and MYC/BCL2 Status on the Risk of Central Nervous System Relapse in Primary Breast Diffuse Large B-Cell Lymphoma
Impact of Cell-of-Origin and MYC/BCL2 Status on the Risk of Central Nervous System Relapse in Primary Breast Diffuse Large B-Cell Lymphoma Open
MYC/BCL2 DE and synchronous bilateral breast involvement may help identify patients at higher risk for CNS relapse. Further studies are warranted.
View article: Expression and role of PD-L1 and SOX10 in hepatocellular carcinoma
Expression and role of PD-L1 and SOX10 in hepatocellular carcinoma Open
View article: Impact of SAMHD1 and phosphorylated ATM levels on the progression and prognosis of patients with soft tissue sarcoma
Impact of SAMHD1 and phosphorylated ATM levels on the progression and prognosis of patients with soft tissue sarcoma Open
Soft tissue sarcomas (STSs) are rare and heterogeneous malignancies that are often associated with a poor prognosis, particularly in advanced stages. DNA damage repair (DDR) pathways serve a crucial role in cancer progression and response …
View article: Sunitinib and TB lymphadenitis: An unexpected link in oncological therapy: a case report
Sunitinib and TB lymphadenitis: An unexpected link in oncological therapy: a case report Open
Rationale: Gastrointestinal stromal tumors (GIST) are neoplasms that originate from the interstitial cells of cajal located in the muscular layer of the gastrointestinal tract. Surgery is the primary treatment options; however, if resectio…
View article: HSD17B7 counters bone loss in estrogen deficiency via estrogen receptor stabilization and mediates the effect of raloxifene
HSD17B7 counters bone loss in estrogen deficiency via estrogen receptor stabilization and mediates the effect of raloxifene Open
Estrogen receptor (ER) α is a key regulator of osteoclasts in osteoporosis induced by estrogen deficiency. Although ERα is regulated through interactions with various coactivators, the precise mechanisms remain unknown. We used LC-MS/MS to…
View article: PD-L1 and ALK expressions in stages III and IV colorectal cancer and their correlation with clinicopathological features
PD-L1 and ALK expressions in stages III and IV colorectal cancer and their correlation with clinicopathological features Open
Colorectal cancer (CRC) is a type of cancer with a high recurrence rate. Studies are in the progress to identify effective treatments for CRC patients. We aimed to compare the expression of programmed death-ligand 1 (PD-L1) and anaplastic …
View article: Malignant Pilomatricoma with Lung Metastases: A Case Report and Literature Review
Malignant Pilomatricoma with Lung Metastases: A Case Report and Literature Review Open
Malignant pilomatricoma, an extremely rare tumor arising from hair follicles, most commonly occurs on the head, neck, and back. This tumor exhibits several noteworthy characteristics. First, it frequently recurs if it is incompletely excis…
View article: IL-13Rα2 Is Involved in Resistance to Doxorubicin and Survival of Osteosarcoma Patients
IL-13Rα2 Is Involved in Resistance to Doxorubicin and Survival of Osteosarcoma Patients Open
Background/Objectives: Interleukin 13 receptor alpha 2 (IL-13Rα2) is a receptor with a high affinity for IL-13 and is involved in the progression of human cancers. However, studies on the role of IL-13Rα2 in osteosarcoma are limited. There…
View article: Incidence and pattern of second primary cancer in patients diagnosed with primary cancer
Incidence and pattern of second primary cancer in patients diagnosed with primary cancer Open
The long survival of patients with primary cancer increases the chance of such patients developing second primary cancer (SPC). The development of SPC in cancer survivors exerts a large psychological, social and economic burden on patients…
View article: PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients
PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients Open
PAK4 and PD-L1 have been suggested as novel therapeutic targets in human cancers. Moreover, PAK4 has been suggested to be a molecule closely related to the immune evasion of cancers. Therefore, this study evaluated the roles of PAK4 and PD…
View article: Hemophagocytic lymphohistiocytosis triggered by relapsing polychondritis: A case report
Hemophagocytic lymphohistiocytosis triggered by relapsing polychondritis: A case report Open
BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder caused by abnormal histiocytes and T cell activation. In adults, it is predominantly associated with infections, cancers, and autoimmune diseases. Rel…
View article: Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval
Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval Open
Key message Our case highlights the importance of follow‐up. Previous meta‐analysis has shown that patients with sub‐centimetre nodules may have extended follow‐up intervals before requiring intervention, unlike those with larger nodules e…
View article: Unveiling the unprecedented – Very late brain metastasis in cholangiocarcinoma: A case report and comprehensive analysis
Unveiling the unprecedented – Very late brain metastasis in cholangiocarcinoma: A case report and comprehensive analysis Open
Rationale: Cholangiocarcinoma (CCA) frequently invades nearby lymph nodes, the liver, and lungs. The liver and lungs are also common anatomic sites for the first recurrence of CCA. However, metastasis to the brain is exceptionally rare. Pa…
View article: Fibrosarcomatous Transformation in Dermatofibrosarcoma Protuberans of theMale Breast and its Association with Magnetic Resonance Imaging andImmunohistopathologic Features
Fibrosarcomatous Transformation in Dermatofibrosarcoma Protuberans of theMale Breast and its Association with Magnetic Resonance Imaging andImmunohistopathologic Features Open
Background: Dermatofibrosarcoma Protuberans (DFSP) is a rare soft tissue sarcoma, accounting for approximately 1% of all tumors; however, DFSP of the breast is extremely rare. Moreover, DFSP generally has a low malignant potential and is c…
View article: SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity Open
View article: Author Correction: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
Author Correction: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1 Open
View article: FAM83H Expression Is Associated with Tumor-Infiltrating PD1-Positive Lymphocytes and Predicts the Survival of Breast Carcinoma Patients
FAM83H Expression Is Associated with Tumor-Infiltrating PD1-Positive Lymphocytes and Predicts the Survival of Breast Carcinoma Patients Open
Background: FAM83H has been implicated in cancer progression, and PD1 is an important target for anti-cancer immune checkpoint therapy. Recent studies suggest an association between FAM83H expression and immune infiltration. However, studi…
View article: Graft lymphoma in a kidney transplant recipient: a case report
Graft lymphoma in a kidney transplant recipient: a case report Open
Posttransplant lymphoproliferative disorders (PTLDs) are severe complications with heterogeneous clinical pictures involving abnormal lymphoproliferation in solid organ transplants and are known to be closely associated with Epstein-Barr v…
View article: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1 Open
PPARα corepressor NCoR1 is a key regulator of fatty acid β-oxidation and ketogenesis. However, its regulatory mechanism is largely unknown. Here, we report that oncoprotein p21-activated kinase 4 (PAK4) is an NCoR1 kinase. Specifically, PA…
View article: Treatment of malignant perivascular epithelioid cell tumor (PEComa) on the knee with an anterolateral thigh free flap: A case report
Treatment of malignant perivascular epithelioid cell tumor (PEComa) on the knee with an anterolateral thigh free flap: A case report Open
Rationale: The World Health Organization defines a perivascular epithelioid cell tumor (PEComa) as a mesenchymal neoplasia composed of perivascular epithelioid cells with characteristic morphological and immunohistochemical features. Altho…
View article: Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged
Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged Open
Aging is an independent risk factor for recurrent tearing after surgical repair of rotator cuff ruptures around the tendon-to-bone area. However, aging signature factors and related mechanisms involved in the healing of the rotator cuff ar…
View article: Acute myelomonocytic leukemia and T-lymphoblastic lymphoma as simultaneous bilineage hematologic malignancy treated with decitabine: A case report
Acute myelomonocytic leukemia and T-lymphoblastic lymphoma as simultaneous bilineage hematologic malignancy treated with decitabine: A case report Open
The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the const…
View article: Bilobetin induces apoptosis in human hepatocellular carcinoma cells via ROS level elevation and inhibition of CYP2J2
Bilobetin induces apoptosis in human hepatocellular carcinoma cells via ROS level elevation and inhibition of CYP2J2 Open
Bilobetin is a biflavonoid isolated from the leaves of Ginkgo biloba. Bilobetin displays several biological effects, however, the activities of bilobetin against cancer have been solely demonstrated. Thus, the aim of this study is investig…
View article: Co‐operative roles of IL‐4Rα and IL‐13Rα1 in the progression of ovarian carcinomas and the survival of ovarian carcinoma patients
Co‐operative roles of IL‐4Rα and IL‐13Rα1 in the progression of ovarian carcinomas and the survival of ovarian carcinoma patients Open
Dear Editor, Recently, there has been a rise in interest in the roles of cytokines and cytokine receptors in malignant human tumors. Cytokine receptors, especially type II interleukin-4 receptor (IL-4R), have recently been examined as nove…
View article: Supplementary Information, Supplementary References, Supplementary Figures 1-2, Supplementary Tables 1-10 from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma
Supplementary Information, Supplementary References, Supplementary Figures 1-2, Supplementary Tables 1-10 from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma Open
Figure S1: Significant concordance between silence of Hippo signature and YAP1 expression in human hepatocellular carcinoma (HCC); Figure S2: Venn diagram of gene lists from two different gene expression signatures; Table S1: Genes in the …
View article: Data from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma
Data from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma Open
Purpose: The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinic…
View article: Data from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma
Data from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma Open
Purpose: The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinic…
View article: Supplementary Information, Supplementary References, Supplementary Figures 1-2, Supplementary Tables 1-10 from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma
Supplementary Information, Supplementary References, Supplementary Figures 1-2, Supplementary Tables 1-10 from Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma Open
Figure S1: Significant concordance between silence of Hippo signature and YAP1 expression in human hepatocellular carcinoma (HCC); Figure S2: Venn diagram of gene lists from two different gene expression signatures; Table S1: Genes in the …
View article: Data from Profound but Dysfunctional Lymphangiogenesis via Vascular Endothelial Growth Factor Ligands from CD11b<sup>+</sup> Macrophages in Advanced Ovarian Cancer
Data from Profound but Dysfunctional Lymphangiogenesis via Vascular Endothelial Growth Factor Ligands from CD11b<sup>+</sup> Macrophages in Advanced Ovarian Cancer Open
Severe ascites is a hallmark of advanced ovarian cancer (OVCA), yet the underlying mechanism that creates an imbalance between peritoneal vascular leakage and lymphatic drainage is unknown. Here, we identified and characterized peritoneal …
View article: Supplementary Methods, Figures 1-9, Tables 1-2 from Profound but Dysfunctional Lymphangiogenesis via Vascular Endothelial Growth Factor Ligands from CD11b<sup>+</sup> Macrophages in Advanced Ovarian Cancer
Supplementary Methods, Figures 1-9, Tables 1-2 from Profound but Dysfunctional Lymphangiogenesis via Vascular Endothelial Growth Factor Ligands from CD11b<sup>+</sup> Macrophages in Advanced Ovarian Cancer Open
Supplementary Methods, Figures 1-9, Tables 1-2 from Profound but Dysfunctional Lymphangiogenesis via Vascular Endothelial Growth Factor Ligands from CD11b+ Macrophages in Advanced Ovarian Cancer