Kyung Ku Jang
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View article: Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis
Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis Open
SUMMARY Intestinal stem cells (ISCs) mediate the continuous renewal of the epithelium during homeostasis and recovery from injury. To investigate the molecular impact of inflammation on human ISCs, we established an organoid model derived …
View article: Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88
Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88 Open
View article: Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness
Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness Open
Background & Aims Despite increasing therapeutic options in the treatment of ulcerative colitis (UC), achieving disease remission remains a major clinical challenge. Nonresponse to therapy is common and clinicians have little guidance in s…
View article: Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab
Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab Open
View article: Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization Open
View article: Antimicrobial overproduction sustains intestinal inflammation by inhibiting<i>Enterococcus</i>colonization
Antimicrobial overproduction sustains intestinal inflammation by inhibiting<i>Enterococcus</i>colonization Open
SUMMARY Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in t…
View article: Retraction Note to: Identification of the Vibrio vulnificus htpG Gene and Its Influence on Cold Shock Recovery
Retraction Note to: Identification of the Vibrio vulnificus htpG Gene and Its Influence on Cold Shock Recovery Open
The Editor in Chief has retracted this article. Based on the conclusions of investigation carried out by the Committee on Research Integrity of Seoul National University, the editorial board concluded that the article represents unjustifie…
View article: Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection
Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection Open
Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly variable for reasons that are not understood. In this study, we used intestinal organoid–derived cultures differentiated from primary human specimens a…
View article: IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment Open
View article: Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro
Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro Open
Epidemic RNA viruses seem to arise year after year leading to countless infections and devastating disease. SARS-CoV-2 is the most recent of these viruses, but there will undoubtedly be more to come. While effective SARS-CoV-2 vaccines are…
View article: Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection
Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection Open
Gastrointestinal effects associated with COVID-19 are highly variable for reasons that are not understood. In this study, we used intestinal organoid-derived cultures differentiated from primary human specimens as a model to examine inter-…
View article: Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies
Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies Open
View article: Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface
Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface Open
View article: A MARTX Toxin <i>rtxA</i> Gene Is Controlled by Host Environmental Signals through a CRP-Coordinated Regulatory Network in Vibrio vulnificus
A MARTX Toxin <i>rtxA</i> Gene Is Controlled by Host Environmental Signals through a CRP-Coordinated Regulatory Network in Vibrio vulnificus Open
A MARTX toxin, RtxA, is an essential virulence factor of many pathogens, including Vibrio species. H-NS and HlyU repress and derepress, respectively, rtxA expression of a life-threatening pathogen, Vibrio vulnificus . We found that Lrp dir…
View article: The transcriptional regulator IscR integrates host-derived nitrosative stress and iron starvation in activation of the vvhBA operon in Vibrio vulnificus
The transcriptional regulator IscR integrates host-derived nitrosative stress and iron starvation in activation of the vvhBA operon in Vibrio vulnificus Open
View article: Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species
Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species Open
Increasing antibiotic resistance has led to the development of new strategies to combat bacterial infection. Anti-virulence strategies that impair virulence of bacterial pathogens are one of the novel approaches with less selective pressur…
View article: Vibrio vulnificus RtxA Is a Major Factor Driving Inflammatory T Helper Type 17 Cell Responses in vitro and in vivo
Vibrio vulnificus RtxA Is a Major Factor Driving Inflammatory T Helper Type 17 Cell Responses in vitro and in vivo Open
T helper type 17 (Th17) cells are a subset of pro-inflammatory T helper cells that mediate host defense and pathological inflammation. We have previously reported that host dendritic cells (DCs) infected with Vibrio vulnificus induc…
View article: QStatin, a Selective Inhibitor of Quorum Sensing in <i>Vibrio</i> Species
QStatin, a Selective Inhibitor of Quorum Sensing in <i>Vibrio</i> Species Open
Pathogenic Vibrio species cause diseases in diverse marine animals reared in aquaculture. Since their pathogenesis, persistence, and survival in marine environments are regulated by quorum sensing (QS), QS interference has attracted attent…
View article: Crystal structure of peroxiredoxin 3 from <i>Vibrio vulnificus</i> and its implications for scavenging peroxides and nitric oxide
Crystal structure of peroxiredoxin 3 from <i>Vibrio vulnificus</i> and its implications for scavenging peroxides and nitric oxide Open
Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidase enzymes. Recently, a new type of Prx, Vv Prx3, was identified in the pathogenic bacterium Vibrio vulnificus as being important for survival in macrophages. It employs only one …
View article: Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability
Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability Open
Vibrio vulnificus (V. vulnificus) is a gram-negative bacterium, which causes life-threatening septicemia and gastroenteritis through the consumption of contaminated seafood or wound infection. In addition, V. vulnificus infection is known …
View article: Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis
Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis Open
The marine bacterium Vibrio vulnificus causes food-borne diseases, which may lead to life-threatening septicemia in some individuals. Therefore, identifying virulence factors in V. vulnificus is of high priority. We performed…
View article: A Vibrio vulnificus VvpM Induces IL-1β Production Coupled with Necrotic Macrophage Death via Distinct Spatial Targeting by ANXA2
A Vibrio vulnificus VvpM Induces IL-1β Production Coupled with Necrotic Macrophage Death via Distinct Spatial Targeting by ANXA2 Open
An inflammatory form of phagocyte death evoked by the Gram-negative bacterium Vibrio (V.) vulnificus (WT) is one of hallmarks to promote their colonization, but the virulence factor and infectious mechanism involved in this process …
View article: Crystal Structure of the Regulatory Domain of AphB from Vibrio vulnificus, a Virulence Gene Regulator
Crystal Structure of the Regulatory Domain of AphB from Vibrio vulnificus, a Virulence Gene Regulator Open
The transcriptional activator AphB has been implicated in acid resistance and pathogenesis in the food borne pathogens Vibrio vulnificus and Vibrio cholerae. To date, the full-length AphB crystal structure of V. cholerae
View article: Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway
Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway Open
VvhA, a virulent factor of Vibrio (V. ) vulnificus , induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of VvhA in autophagy-related cell death has not been elucidated…
View article: Regulatory Characteristics of Vibrio vulnificus gbpA Gene Encoding a Mucin-binding Protein Essential for Pathogenesis
Regulatory Characteristics of Vibrio vulnificus gbpA Gene Encoding a Mucin-binding Protein Essential for Pathogenesis Open
View article: Acknowledgment to Reviewers for 2015
Acknowledgment to Reviewers for 2015 Open
View article: Erratum to: Identification of the Vibrio vulnificus htpG gene and its influence on cold shock recovery
Erratum to: Identification of the Vibrio vulnificus htpG gene and its influence on cold shock recovery Open
View article: Vibrio vulnificus VvpE inhibits mucin 2 expression by hypermethylation via lipid raft-mediated ROS signaling in intestinal epithelial cells
Vibrio vulnificus VvpE inhibits mucin 2 expression by hypermethylation via lipid raft-mediated ROS signaling in intestinal epithelial cells Open