Jack A. Tuszyński
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View article: A Unified Holographic Framework for neural computation and consciousness: From lipid membranes to the Schumann resonance
A Unified Holographic Framework for neural computation and consciousness: From lipid membranes to the Schumann resonance Open
Understanding conscious experience requires looking beyond neuronal circuits alone. We propose that lipid membranes, vicinal water, and cerebrospinal fluid (CSF) form a coherent substrate capable of holographic encoding and coupling to end…
View article: EMI model: A scale free biophysical framework for human consciousness, cognition and behaviour
EMI model: A scale free biophysical framework for human consciousness, cognition and behaviour Open
Understanding consciousness, cognition, and behaviour requires an integrated framework capable of bridging neurobiology, physics, and information theory. In this paper, we propose the Energy-Mass-Information (EMI) framework as a novel para…
View article: Beyond Gamma: Synergistic Potential of 10 Hz Alpha and 40 Hz Gamma Photobiomodulation in Alzheimer's Disease Treatment
Beyond Gamma: Synergistic Potential of 10 Hz Alpha and 40 Hz Gamma Photobiomodulation in Alzheimer's Disease Treatment Open
Background Gamma (40 Hz) sensory stimulation has been proposed as a non‐pharmaceutical therapy for Alzheimer's disease (AD) due to its association with reduced pathology in animal studies. However, the focus on gamma overlooks the potentia…
View article: Delineating SARS-CoV-2 spike protein and antibodies interaction interfaces via siamese neural networks: A geometric and image-based analysis
Delineating SARS-CoV-2 spike protein and antibodies interaction interfaces via siamese neural networks: A geometric and image-based analysis Open
The analysis of molecular interactions between antigens and antibodies is crucial for understanding the immunological mechanisms underlying the immune response and for developing effective therapies against various diseases. In this contex…
View article: Potent broad-spectrum anti-coronaviral frameshift inhibitors from virtual screen of RNA binding
Potent broad-spectrum anti-coronaviral frameshift inhibitors from virtual screen of RNA binding Open
Coronavirus genomes contain an RNA pseudoknot that directs −1 programmed ribosomal frameshifting (−1 PRF) to control expression of viral proteins crucial for replication. Ligands that inhibit −1 PRF can thus attenuate viral propagation and…
View article: Parametric Resonance via Neuronal Microtubules: Filtering Optical Signals by Tryptophan Qubits
Parametric Resonance via Neuronal Microtubules: Filtering Optical Signals by Tryptophan Qubits Open
This paper aims to address the possibility of parametric resonance effects in microtubules via tryptophan qubits, using the Hamiltonian of the cavity quantum electrodynamics (QED) model involving photons in a waveguide and the surrounding …
View article: A physical model of neuronal membrane excitations as a mechanism of holographic image formation in the brain
A physical model of neuronal membrane excitations as a mechanism of holographic image formation in the brain Open
This paper introduces a computational model that underlies an electromagnetic theory of inter-neuronal interactions in the human brain. The hypothesis underlying this model aims to explain human perception, cognition, memory, and conscious…
View article: Computational discovery of potential therapeutic agents against brain-eating amoeba (Naegleria fowleri)
Computational discovery of potential therapeutic agents against brain-eating amoeba (Naegleria fowleri) Open
Naegleria fowleri is a human and animal pathogen well-known for its ability to digest neurons and astrocytes of the host’s brain, causing a haemorrhagic and necrotizing inflammation called Primary Amoebic Meningoencephalitis . Although inf…
View article: Integrative chronic pain management: a narrative review
Integrative chronic pain management: a narrative review Open
Chronic pain, a pervasive public health issue, significantly contributes to the opioid crisis in the United States, where opioid-related deaths have escalated dramatically since the late 1990s. This narrative review explores integrative ap…
View article: Exploring the role of phospholipid membrane composition in biomolecular simulations: towards tailored membrane models
Exploring the role of phospholipid membrane composition in biomolecular simulations: towards tailored membrane models Open
Cell membranes are highly complex biological systems composed of a wide array of lipid species, distributed asymmetrically across the bilayer leaflets. This highly specific lipid composition is essential for maintaining membrane integrity …
View article: Synergism or mirage: Current progress and an empirical approach for elucidating combination drug effects
Synergism or mirage: Current progress and an empirical approach for elucidating combination drug effects Open
In the context of the multitarget paradigm, fixed-dose combination (FDC) drugs, that is, compounds that synergistically target multiple sites when combined, have gained attention for treating complex diseases like cancers and viral infecti…
View article: Computational Search for Inhibitors of SOD1 Mutant Infectivity as Potential Therapeutics for ALS Disease
Computational Search for Inhibitors of SOD1 Mutant Infectivity as Potential Therapeutics for ALS Disease Open
Familial amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective degeneration of motor neurons. Among the main genetic causes of ALS, over 200 mutations have been identified in the Cu/Z…
View article: Recent Update on siRNA Therapeutics
Recent Update on siRNA Therapeutics Open
Small interfering RNA (siRNA) has been deemed a promising therapeutic method for treating diverse diseases. siRNA-based therapeutics provide a distinct mechanism of action by selectively targeting and silencing disease-causing genes at the…
View article: Waveguide Quantum Electrodynamics: Tryptophans Entangled with Water as Data Qubits in a Microtubule
Waveguide Quantum Electrodynamics: Tryptophans Entangled with Water as Data Qubits in a Microtubule Open
In this paper, we introduce waveguide Quantum Electrodynamics (wQED) for the description of tryptophans in microtubules representing data qubits for information storage and, possibly, information processing. We propose a Hamiltonian in wQE…
View article: A comprehensive primer and review of PROTACs and their In Silico design
A comprehensive primer and review of PROTACs and their In Silico design Open
The cutting-edge technique of Proteolysis Targeting Chimeras, or PROTACs, has gained significant attention as a viable approach for specific protein degradation. This innovative technology has vast potential in fields such as cancer therap…
View article: Search for Highly Ionizing Particles in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mi>p</mml:mi></mml:math> Collisions during LHC Run 2 Using the Full MoEDAL Detector
Search for Highly Ionizing Particles in Collisions during LHC Run 2 Using the Full MoEDAL Detector Open
This search for magnetic monopoles (MMs) and high electric charge objects (HECOs) with spins 0, 1/2, and 1, uses for the first time the full MoEDAL detector, exposed to 6.46 fb−1 proton-proton collisions at 13 TeV. The results are interpr…
View article: Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies
Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies Open
Background: Age-related decline in musculoskeletal function is a significant concern, particularly in Western countries facing demographic shifts and increased healthcare demands. This review examines the typical trajectories of musculoske…
View article: External low energy electromagnetic fields affect heart dynamics: surrogate for system synchronization, chaos control and cancer patient’s health
External low energy electromagnetic fields affect heart dynamics: surrogate for system synchronization, chaos control and cancer patient’s health Open
All cells in the human body, including cancer cells, possess specific electrical properties crucial for their functions. These properties are notably different between normal and cancerous cells. Cancer cells are characterized by autonomou…
View article: The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury
The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury Open
Injury from spike protein, whether induced by COVID‐19 infection or vaccination, constitutes a significant health concern for numerous individuals. Considerable heterogeneity exists in individual responses to both COVID‐19 infection and va…
View article: Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body – a comprehensive review
Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body – a comprehensive review Open
A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to posse…
View article: Erratum: First Search for Dyons with the Full MoEDAL Trapping Detector in 13 TeV <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mi>p</mml:mi></mml:math> Collisions [Phys. Rev. Lett. <b>126</b>, 071801 (2021)]
Erratum: First Search for Dyons with the Full MoEDAL Trapping Detector in 13 TeV Collisions [Phys. Rev. Lett. <b>126</b>, 071801 (2021)] Open
This corrects the article DOI: 10.1103/PhysRevLett.126.071801.
View article: Non-Equilibrium Quantum Brain Dynamics: Water Coupled with Phonons and Photons
Non-Equilibrium Quantum Brain Dynamics: Water Coupled with Phonons and Photons Open
We investigate Quantum Electrodynamics (QED) of water coupled with sound and light, namely Quantum Brain Dynamics (QBD) of water, phonons and photons. We provide phonon degrees of freedom as additional quanta in the framework of QBD in thi…
View article: Life in the Years: Maximizing Physical and Cognitive Health in the Elderly
Life in the Years: Maximizing Physical and Cognitive Health in the Elderly Open
Biomarker-based tests are capable of predicting one’s biological age and mortality risk. To complement the suite of biomarker-based measurements, physical and cognitive performance tests can also improve the predictability of these m…